Haematological studies on wild black rhinoceros (Diceros bicornis)‐evidence of an unstable haemoglobin

Paul, Beverley; Toit, R. Du; Lloyd, Shän; Mandisodza, A.

doi:10.1111/j.1469-7998.1988.tb03748.x

Cited by 2 publications

(1 citation statement)

References 2 publications

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“…We observed that 10-15% of circulating erythrocytes in apparently normal rhinoceroses contained single large Heinz bodies, and others have made similar observations [19][20][21]. In two animals thus studied, exposure to acetylphenylhydrazine increased the percentage of cells containing multiple Heinz bodies to -90% within 30 min, but only to 25% if the cells had been preincubated with adenosine and glucose to increase their intracellular ATP (see below).…”

Section: Glutathione Stability and Hmp Shunt Metabolismsupporting

confidence: 77%

Acute episodic hemolysis in the African black rhinoceros as an analogue of human glucose‐6‐phosphate dehydrogenase deficiency

Paglia

1993

American J Hematol

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Sudden episodes of massive hemolysis have become the most common cause of death among captive black rhinoceroses, and there is evidence that they occur in the wild as well. We have observed radically unique enzyme and metabolite profiles in normal rhinoceros erythrocytes compared to humans and other mammals, including marked deficiencies of intracellular adenosine triphosphate (ATP), catalase, adenosine deaminase, and other enzymes involved in glycolysis, glutathione cycling, and nucleotide metabolism. Minimal concentrations of ATP appear to impair effective acceleration of hexosemonophosphate shunt activity in response to oxidants by restricting substrate generation at the hexokinase step. Antioxidant defenses are further compromised by catalase deficiency, which may be a general characteristic of rhinoceros erythrocytes, perhaps related to the common occurrence of severe mucocutaneous ulcerative disease. It is proposed that erythrocyte ATP deficiency in rhinoceroses may be an evolutionary adaptation conferring selective advantage against common hemic parasites, comparable to the role of human glucose-6-phosphate dehydrogenase (G-6-PD) deficiency in falciparum malaria.

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Section: Glutathione Stability and Hmp Shunt Metabolismsupporting

confidence: 77%

Acute episodic hemolysis in the African black rhinoceros as an analogue of human glucose‐6‐phosphate dehydrogenase deficiency

Paglia

1993

American J Hematol

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Morphology of rhinoceros platelets

1999

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Basic hematological information about rhinoceros species is limited. In this study, we have determined the platelet counts and described the platelet morphology of free‐living white (Ceratotherium simum) and black (Diceros bicornis) rhinoceros using light and electron microscopy. The platelet counts of the two species were similar, but there were significant differences in platelet size as well as morphology between the species. The presence of large, nondiscoid platelet forms, resembling proplatelet or stress platelet forms, were observed in both, although not as often in the white rhinoceros as in the black rhinoceros. J. Morphol. 239:245–253, 1999. © 1999 Wiley‐Liss, Inc.

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Haematological studies on wild black rhinoceros (Diceros bicornis)‐evidence of an unstable haemoglobin

Cited by 2 publications

References 2 publications

Acute episodic hemolysis in the African black rhinoceros as an analogue of human glucose‐6‐phosphate dehydrogenase deficiency

Acute episodic hemolysis in the African black rhinoceros as an analogue of human glucose‐6‐phosphate dehydrogenase deficiency

Morphology of rhinoceros platelets

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