Haematology in dengue and dengue haemorrhagic fever

Srichaikul, Tanomsri; Nimmannitya, Suchitra

doi:10.1053/beha.2000.0073

Cited by 152 publications

(130 citation statements)

References 32 publications

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“…We found that sST2 had a negative correlation with platelet count and WBC count and a positive correlation with the prolonged thrombin time and AST/ALT activity. Dengue virus infections are characterized by thrombocytopenia [39], and we found that sST2 protein levels were higher as the platelet counts were lower. We found the same tendency for WBC count.…”

Section: Discussionmentioning

confidence: 61%

Elevated levels of soluble ST2 protein in dengue virus infected patients

et al. 2008

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Levels of the soluble form of the interleukin-1 receptor like 1 protein (IL-1RL-1 / ST2) are elevated in the serum of patients with diseases characterized by an inflammatory response. The objective of this study was to determine the concentration of soluble ST2 (sST2) in dengue infected patients during the course of the disease. Twenty four patients with confirmed dengue infection, classified as dengue fever, and eleven patients with other febrile illness (OFI) were evaluated. Levels of sST2 in serum and laboratory variables usually altered during dengue infections were measured. Dengue infected patients had higher serum sST2 levels than OFI at the end of the febrile stage and at defervescence (p=0.0088 and p=0.0004 respectively). Patients with secondary dengue infections had higher serum sST2 levels compared with patients with primary dengue infections (p=0.047 at last day of fever and p=0.030 at defervescence). Furthermore, in dengue infected patients, we found a significant negative correlation of sST2 with platelet and WBC counts, and positive correlation with thrombin time and transaminases activity. We suggest that sST2 could be a potential marker of dengue infection, could be associated with severity or could play a role in the immune response in secondary dengue virus infection.

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Section: Discussionmentioning

confidence: 61%

Elevated levels of soluble ST2 protein in dengue virus infected patients

et al. 2008

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“…The major pathophysiologic hallmark that determine disease severity and distinguish DHF from DF and other viral haemorrhagic fevers are plasma leakage due to increased vascular permeability and abnormal hemostasis. Hypovolemic shock occurs as a consequence of and subsequent to, critical plasma volume loss [11]. Abnormal hemostasis including increased capillary fragility, thrombocytopenia, impaired platelet function, consumptive coagulopathy and in the most severe form disseminated intravascular coagulation (DIC) contribute to varying degree of hemorrhagic manifestations [12].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Platelets as Predictive Parameters in Dengue Fever

Krishnamurthy

Manasa

Pallavi

et al. 2011

Indian J Hematol Blood Transfus

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Dengue is an arboviral disease and occurs in tropical countries where over 2.5 billion people are at risk of infection. Each year an estimated 100 million cases of dengue fever (DF) occur and between 2.5 and 5 lakh cases of dengue hemorrhagic fever (DHF) are reported to WHO. Severe thrombocytopenia and increased vascular permeability are two major characteristics of DHF. A study was conducted to note the relationship between the platelet counts and severity of the disease in pediatric cases of dengue fever. Platelet counts were found to be predictive as well as recovery parameter of DF/DHF/DSS.

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“…Approximately 2·5 billion people in more than 100 countries are currently at risk of infection, with an estimated 50 million infections per year [2]. The four serotypes of dengue virus induce a wide spectrum of clinical manifestations, which are associated frequently with haemorrhagic diathesis [3]. While dengue fever (DF) is a self-limited febrile illness, dengue haemorrhagic fever (DHF) is characterized by prominent haemorrhagic manifestations associated with thrombocytopenia and an increased vascular permeability.…”

Section: Introductionmentioning

confidence: 99%

“…Because thrombocytopenia is more prominent in DHF than in DF [3], we hypothesized that the increased level of PAIgG might be associated with the severity of the disease as well as thrombocytopenia. In addition, the role of platelet-associated IgM (PAIgM) remains uncertain in this disease, although the level of antidengue virus IgM is also elevated in the sera of patients with secondary infections [18].…”

Section: Introductionmentioning

confidence: 99%

Association of increased platelet-associated immunoglobulins with thrombocytopenia and the severity of disease in secondary dengue virus infections

Saito¹,

Oishi²,

Inoue

et al. 2004

Clinical and Experimental Immunology

107

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SUMMARY Severe thrombocytopenia and increased vascular permeability are two major characteristics of dengue haemorrhagic fever (DHF). To develop a better understanding of the roles of platelet-associated IgG (PAIgG) and IgM (PAIgM) in inducing thrombocytopenia and its severity of disease in patients with secondary dengue virus infection, the relationship between the PAIgG or PAIgM levels and disease severity as well as thrombocytopenia was examined in 78 patients with acute phase secondary infection in a prospective hospital-based study. The decrease in platelet count during the acute phase recovered significantly during the convalescent phase. In contrast, the increased levels of PAIgG or PAIgM that occurred during the acute phase of these patients decreased significantly during the convalescent phase. An inverse correlation between platelet count and PAIgG or PAIgM levels was found in these patients. Anti-dengue virus IgG and IgM activity was found in platelet eluates from 10 patients in an acute phase of secondary infection. Increased levels of PAIgG or PAIgM were significantly higher in DHF than those in dengue fever (DF). An increased level of PAIgM was associated independently with the development of DHF, representing a possible predictor of DHF with a high specificity. Our present data suggest that platelet-associated immunoglobulins involving antidengue virus activity play a pivotal role in the induction of thrombocytopenia and the severity of the disease in secondary dengue virus infections.

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Haematology in dengue and dengue haemorrhagic fever

Cited by 152 publications

References 32 publications

Elevated levels of soluble ST2 protein in dengue virus infected patients

Elevated levels of soluble ST2 protein in dengue virus infected patients

Evaluation of Platelets as Predictive Parameters in Dengue Fever

Association of increased platelet-associated immunoglobulins with thrombocytopenia and the severity of disease in secondary dengue virus infections

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