Haematopoiesis radioprotection in Balb/c mice by an aqueous mycelium extract from the Basidiomycete<i>Pleurotus ostreatus</i>mushroom

Llauradó, Gabriel; Morris, Humberto J.; Tamayo, Vivian Robert; Lebeque, Yamila; Beltrán, Yaixa; Marcos, J.; Moukha, Serge; Creppy, E. E.; Bermúdez, Rosa C.

doi:10.1080/14786419.2014.983918

Cited by 10 publications

(5 citation statements)

References 7 publications

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“…In previous studies, we reported the immunomodulating activity of a hot-water mycelial extract from Pleurotus ostreatus against the immunosuppression caused by cyclophosphamide or whole-body irradiation in mice. 32,33 To our knowledge, this is the first report linking some bioactivities of Pleurotus' mycelia with their potential applications in phyto-(myco-) cosmetics. Better insight into the different roles of multiple active compounds and the mechanisms underlying their biological action will accelerate commercial production of novel pharmaceuticals and cosmetic products based on waterextracts from mycelia of Pleurotus sp.…”

Section: Introductionmentioning

confidence: 88%

Mycelia from Pleurotus sp. (oyster mushroom): a new wave of antimicrobials, anticancer and antioxidant bio-ingredients

Morris¹,

Beltrán²,

Llauradó³

et al. 2017

Int J Phytocosmetics Natu Ingredients

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Introduction: There has been an upsurge of interest in mushrooms, such as Pleurotus species, as an important source of bioactive compounds. Mycelia-submerged culture represents a promising approach to search new safe and healthy myco-products with standardized quality in addition to mushroom fruiting bodies. Methods: The study examined the in vitro antimicrobial, antitumor and antioxidant activities of a hotwater extract from Pleurotus sp. mycelium. The antimicrobial activity was screened through the activation of the microbial autolytic system of four bacteria and four yeast strains. The anti-proliferative effects on NB4 human leukemia cells were measured by flow-cytometry analyses. The antioxidant activity was investigated by the scavenging of DPPH and ABTS radicals, the reducing power and the inhibition of lipid peroxidation. Results: The extract activated the microbial autolytic system of eight strains: 7 autolyzing strains with intensity values (Is) ranging from 2.7% in Candida sp. to 36.1% in Saccharomyces cerevisiae. Thus, the microbial autolytic system of the strains tested (including Gram-positive and gram-negative bacteria as well as yeasts) could be activated in vitro by mycelial extract. Pleurotus extract reduced the viability of NB4 leukemia cells, particularly at the concentration of 200 μg/mL to 82% compared to control cells, and induced apoptosis demonstrated by an increase in annexin V-FITC+ cells (25% at 200 μg/mL). At 10 mg/mL, the extract showed the most potent scavenging effects for DPPH and ABTS radicals (96% and 55%, respectively) and the inhibition of lipid peroxidation (52%). The mushroom extract at 5 mg/ mL manifested reducing power of 1.105. Although carbohydrates (76.8%, w/w) appear to be the most important bioactive compounds, secondary metabolites, like phenolics, would also contribute to the antioxidant, antimicrobial and anti-proliferative activities. Conclusion: The hot-water extract obtained from Pleurotus mycelium, in light of its in vitro antimicrobial, antitumor and antioxidant effects could be considered a good candidate for developing nutraceuticals and for designing innovative myco-therapeutics and phytocosmetics applications.

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Section: Introductionmentioning

confidence: 88%

Mycelia from Pleurotus sp. (oyster mushroom): a new wave of antimicrobials, anticancer and antioxidant bio-ingredients

Morris¹,

Beltrán²,

Llauradó³

et al. 2017

Int J Phytocosmetics Natu Ingredients

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“…Polysaccharides obtained from Pleurotus ostreatus possess a wide range of biological activity in vivo and in vitro as radioprotection, preventive effect on recurrent respiratory tract infections and others [15][16][17]. Thus, a significant reduction of cholesterol levels in mice was observed in serum (31-46%) and liver (25-30%) at a dose of 5% of oyster mushroom for all periods (8,16,28, and 52 weeks) was shown [18].…”

Section: Introductionmentioning

confidence: 99%

Fortification of dairy product Narine with polysaccharides from oyster mushroom

Antonceva

Shamtsyan

2020

E3S Web of Conf.

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Mushrooms are rich in biologically active substances. Basidiomycete oyster mushroom or Pleurotus ostreatus is not only widely used in food, but also have radioprotection, preventive effect on recurrent respiratory tract infections, hypocholesterolic action, antitumor effect, strong immunostimulatory activity and other beneficial medical effects. It is considered that β-glucans play significant role in the biological activities of the oyster mushroom. The aim of this research was to study the effect of the addition of various β-glucan containing preparations obtained from the submerged biomass of P. ostreatus on the process of milk fermentation and properties of the finished product. Preparations of β-glucans obtained from submerged cultured P. ostreatus biomass were obtained using different extraction protocols. The content of β-glucans in preparations was determined using Assay Kit (Megazyme). Preparations were added to milk in different concentrations before the introduction of starter culture. A starter containing Lactobacillus acidophilus n.v. Er 317/402 strain «Narine» was used for fermentation. The titratable acidity was controlled during the fermentation. Physicochemical, structural-mechanical properties (water holding capacity) of the obtained samples were studied. The sensory evaluation of the products was evaluated. Results show that the addition of preparations increase the glycolytic activity. Structural-mechanical properties of yogurt samples fortified by β-glucan-containing preparations depend on the preparation and its concentration. Sensory evaluation showed that experimental samples differed not only from the control sample but also from each other.

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“…A bundle of reports concerning oyster mushrooms brings to light the new substances with such properties as an antibiotic, antitumor, antiviral, and anticholesterolic activities (Selegean, Putz & Rugea, 2009). The radioprotective effects of an extract from Pleurotus ostreatus mycelium have been studied by Lauradó et al (2015) and administered in a prophylactic schedule to Balb/c mice. In general, compounds with pharmacological activities that identified in fungi, stimulate different cell populations of the immune system, such as macrophages, natural killer cells, T -cells, and modulate cytokine system as well (Oloke & Adebayo, 2015).…”

Section: Introductionmentioning

confidence: 99%

Green potential ofPleurotusspp. in biotechnology

Секан

Myronycheva

Karlsson

et al. 2019

PeerJ

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Background The genus Pleurotus is most exploitable xylotrophic fungi, with valuable biotechnological, medical, and nutritional properties. The relevant features of the representatives of this genus to provide attractive low-cost industrial tools have been reported in numerous studies to resolve the pressure of ecological issues. Additionally, a number of Pleurotus species are highly adaptive, do not require any special conditions for growth, and possess specific resistance to contaminating diseases and pests. The unique properties of Pleurotus species widely used in many environmental technologies, such as organic solid waste recycling, chemical pollutant degradation, and bioethanol production. Methodology The literature study encompasses peer-reviewed journals identified by systematic searches of electronic databases such as Google Scholar, NCBI, Springer, ResearchGate, ScienceDirect, and ISI Web of Knowledge. The search scheme was divided into several steps, as described below. Results In this review, we describe studies examining the biotechnological feasibility of Pleurotus spp. to elucidate the importance of this genus for use in green technology. Here, we review areas of application of the genus Pleurotus as a prospective biotechnological tool. Conclusion The incomplete description of some fungal biochemical pathways emphasises the future research goals for this fungal culture.

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Haematopoiesis radioprotection in Balb/c mice by an aqueous mycelium extract from the BasidiomycetePleurotus ostreatusmushroom

Cited by 10 publications

References 7 publications

Mycelia from Pleurotus sp. (oyster mushroom): a new wave of antimicrobials, anticancer and antioxidant bio-ingredients

Mycelia from Pleurotus sp. (oyster mushroom): a new wave of antimicrobials, anticancer and antioxidant bio-ingredients

Fortification of dairy product Narine with polysaccharides from oyster mushroom

Green potential ofPleurotusspp. in biotechnology

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