Haematopoietic-expressed C/EBPβ: A novel transcriptional regulator of hepatic liver metabolism and macrophage foam cells during atherosclerosis?

Thomas, Shane R.

doi:10.1016/j.atherosclerosis.2016.05.015

Cited by 3 publications

(1 citation statement)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…C/EBP beta is a transcription factor belonging to the basic leucine zipper family, and was found to be expressed in multiple types of cells, including myelomonocytic cells, vascular endothelial cells, macrophages and adipocytes [ 30 , 31 ]. C/EBP beta plays important roles in inflammation and regulates the expression of a panel of genes such as TNF, IL-8, IL-1β, IL-12, IL-6, NF-κB and JNK [ 31 – 34 ]. C/EBP beta also exerts key roles in lipid metabolism and inflammation in both the liver and adipose tissue [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Functional rare variant in a C/EBP beta binding site in NINJ2 gene increases the risk of coronary artery disease

Wang

Peng

et al. 2021

Aging

View full text Add to dashboard Cite

Objective: NINJ2 regulates activation of vascular endothelial cells, and genome-wide association studies showed that variants in NINJ2 confer risk to stroke. However, whether variants in NINJ2 are associated with coronary artery disease (CAD) is unknown. Methods: We genotyped rs34166160 in NINJ2 in two independent Chinese GeneID populations which included 2,794 CAD cases and 4,131 controls, and performed genetics association studies. Functional studies were also performed to reveal the mechanisms. Results: Allele rs34166160 significantly confers risk to CAD in the GeneID Hubei population which contained 1,440 CAD cases and 2,660 CAD-free controls (observed P -obs = 6.39 × 10 −3 with an odds ratio (OR) was 3.39, adjusted P -adj = 8.12 × 10 −3 with an OR of 3.10). The association was replicated in another population, GeneID Shandong population contained 1,354 CAD cases and 1,471 controls ( P -obs = 3.33 × 10 −3 with an OR of 3.14, P -adj = 0.01 with an OR of 2.74). After combining the two populations, the association was more significant ( P -obs = 1.57 × 10 −5 with an OR of 3.58, P -adj = 3.41 × 10 −4 with an OR of 2.80). In addition, we found that rs34166160 was associated with the mRNA expression level of NINJ2 and the flanking region of rs34166160 can directly bind with transcriptional factor CCAAT-box/enhancer-binding protein beta, and the risk A allele has more transcription activity than non-risk C allele with or without LPS in HUVEC cells. Conclusions: Our study demonstrates that the functional rare variant rs34166160 in NINJ2 confers risk to CAD for the first time, and these findings further expand the range of the pathology of CAD and atherosclerosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Functional rare variant in a C/EBP beta binding site in NINJ2 gene increases the risk of coronary artery disease

Wang

Peng

et al. 2021

Aging

View full text Add to dashboard Cite

show abstract

Induction of the Coxsackievirus and Adenovirus Receptor in Macrophages During the Formation of Atherosclerotic Plaques

Nilchian

Plant

Parniewska

et al. 2020

The Journal of Infectious Diseases

View full text Add to dashboard Cite

Abstract Multiple viruses are implicated in atherosclerosis but the mechanisms of how they infect cells and contribute to plaque formation in arterial walls are not well understood. Based on reports showing the presence of enterovirus in atherosclerotic plaques we hypothesized that the coxsackie- and adenovirus receptor (CXADR), although absent in normal arteries, could be induced during plaque formation. Large-scale microarray and mass-spectrometry analyses revealed significant upregulation of CXADR mRNA and protein levels in plaque-invested carotid arteries compared to control arteries. Macrophages were identified as a previously unknown cellular source of CXADR in human plaques and plaques from Ldr-/- Apob100/100 mice. CXADR specifically associated with M1-polarized macrophages and foam cells and was experimentally induced during macrophage differentiation. Furthermore, CXADR significantly correlated with receptors for other viruses linked to atherosclerosis. The results show that CXADR is induced in macrophages during plaque formation, suggesting a mechanism by which enterovirus infect cells in atherosclerotic plaques.

show abstract

FOXA3 Polymorphisms Are Associated with Metabolic Parameters in Individuals with Subclinical Atherosclerosis and Healthy Controls—The GEA Mexican Study

et al. 2022

View full text Add to dashboard Cite

FOXA3 is a transcription factor involved in the macrophage cholesterol efflux and macrophage reverse cholesterol transport reducing the atherosclerotic lesions. Thus, the present study aimed to establish if the FOXA3 polymorphisms are associated with subclinical atherosclerosis (SA) and cardiometabolic parameters. Two FOXA3 polymorphisms (rs10410870 and rs10412574) were determined in 386 individuals with SA and 1070 controls. No association with SA was observed. The rs10410870 polymorphism was associated with a low risk of having total cholesterol >200 mg/dL, non-HDL-cholesterol > 160 mg/dL, and a high risk of having LDL pattern B and insulin resistance adipose tissue in individuals with SA, and with a high risk of having interleukin 10 <p25 and magnesium deficiency in controls. The rs10412574 polymorphism was associated with a low risk of insulin resistance of the adipose tissue and a high risk of aspartate aminotransferase >p75 in individuals with SA, and with a low risk of LDL pattern B and a high risk of a magnesium deficiency in controls. Independent analysis in 846 individuals showed that the rs10410870 polymorphism was associated with a high risk of aortic valve calcification. In summary, FOXA3 polymorphisms were not associated with SA; however, they were associated with cardiometabolic parameters in individuals with and without SA.

show abstract

Haematopoietic-expressed C/EBPβ: A novel transcriptional regulator of hepatic liver metabolism and macrophage foam cells during atherosclerosis?

Cited by 3 publications

References 24 publications

Functional rare variant in a C/EBP beta binding site in NINJ2 gene increases the risk of coronary artery disease

Functional rare variant in a C/EBP beta binding site in NINJ2 gene increases the risk of coronary artery disease

Induction of the Coxsackievirus and Adenovirus Receptor in Macrophages During the Formation of Atherosclerotic Plaques

FOXA3 Polymorphisms Are Associated with Metabolic Parameters in Individuals with Subclinical Atherosclerosis and Healthy Controls—The GEA Mexican Study

Contact Info

Product

Resources

About