Haematopoietic malignancies in zoo animals

Hruban, Z.; Vardiman, James W.; Meehan, T.; Frye, Fredric; Carter, W.E.

doi:10.1016/0021-9975(92)90064-2

Cited by 49 publications

(25 citation statements)

References 3 publications

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“…Lymphoid leukemia has been reported more frequently than myeloid leukemia in reptiles (Tocidlowski et al 2001;Garner et al 2004;Georoff et al 2009;Bezjian et al 2013). Myelogenous leukemia was described in a bearded dragon (Pogona vitticeps) based on positive staining of leukemic cells for peroxidase, CAE, L1-calprotectin and histopathology of multiple organs including liver, spleen and bone marrow (Tocidlowski et al 2001) and a gecko, a rattlesnake (Garner et al 2004), a Russell's viper (Daboia russelli), and a Honduran milk snake (Lampropeltis triangulum hondurensis, Hruban et al 1992) based on histopathological characteristics.…”

Section: Discussionmentioning

confidence: 99%

Presumptive granulocytic leukemia in a hognose snake (Heterodon platirhinos)

Rousselet

Norton²,

Wellman

et al. 2017

Veterinary Quarterly

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Section: Discussionmentioning

confidence: 99%

Presumptive granulocytic leukemia in a hognose snake (Heterodon platirhinos)

Rousselet

Norton²,

Wellman

et al. 2017

Veterinary Quarterly

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“…2,[4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]25,26,28 The precise etiology of these tumors is unknown in reptiles but may involve genetic, parasitic, environmental, and viral factors. 20 However, a viral etiology of neoplasia is poorly documented in reptiles.…”

mentioning

confidence: 99%

Lymphoblastic Lymphoma and Leukemic Blood Profile in a Red-Tail Boa (Boa Constrictor Constrictor) with Concurrent Inclusion Body Disease

Schilliger¹,

Selleri

Frye³

2011

J VET Diagn Invest

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Abstract. An adult male wild-caught true red-tail boa (Boa constrictor constrictor), imported from Surinam, was presented for anorexia, extreme lethargy, and coelomic swelling in the cranial third of the body, in the anatomic location of the thymus. The snake died a few minutes after blood sampling via cardiocentesis. Hematology revealed anemia and extreme leukocytosis (820 3 10 3 /ml) characterized by a predominance (95%) of lymphocytes. Necropsy revealed enlargement of most of the visceral organs. Histology confirmed lymphoblastic lymphoma with a leukemic blood profile and diffuse infiltration of some of the heart, thymus, bone marrow, kidney, spleen, lung, and liver. Several large intracytoplasmic eosinophilic inclusion bodies surrounded by narrow clear ''halos'' were identified within gastric mucosal cells, proximal and distal convoluted tubule epithelial cells, and splenic cells. The final diagnosis was lymphoblast lymphoma with a leukemic blood profile and concurrent inclusion body disease.

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“…Cutaneous squamous cell carcinoma, mast cell tumor, pituitary adenoma, myelogenous leukemia, sarcomas, intestinal lymphosarcoma, intestinal plasmacytoma, renal transitional cell carcinoma, hepatic adenoma, oral carcinoma, poorly differentiated subcutaneous sarcoma, subcutaneous neurofibroma, and mammary neoplasms have been reported. 3,4,10,14,17,19,[20][21][22][23][24] Microscopically, both cutaneous tumors had features of neurofibrosarcoma. 11 Neurofibrosarcomas are also called neurogenic sarcoma, malignant schwannoma, and more recently, malignant peripheral nerve sheath tumor (MPNST).…”

mentioning

confidence: 99%

Soft Tissue Sarcomas in the African Hedgehog (Atelerix Albiventris): Microscopic and Immunohistologic Study of Three Cases

Ramos-Vara

2001

J VET Diagn Invest

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Abstract. Three soft tissue tumors from 2 female hedgehogs were examined microscopically and immunohistochemically. Two tumors involved haired skin and the third one was vaginal. Microscopically, the cutaneous tumors had features of malignant peripheral nerve sheath tumor (MPNST), whereas the vaginal tumor was classified only as a spindle cell sarcoma. Immunohistochemically, all 3 tumors were strongly positive for vimentin and strongly to moderately positive for CD10 and neuron-specific enolase but did not stain with antibody to S100 protein, an antigen typically present in human MPNST. The cutaneous tumor from hedgehog no. 1 was examined ultrastructurally and the neoplastic cells resembled fibroblasts. Hedgehog no. 1 was euthanized at the time of the biopsy. The outcome of the other hedgehog was unknown.African hedgehogs (Atelerix albiventris) are popular exotic pets. Consequently, there is demand for information regarding their husbandry and diseases. 22 Neoplastic diseases constitute approximately 30% of the histopathologic diagnoses made in hedgehogs. 22 A search of the Veterinary Medical Diagnostic Laboratory (VMDL), Columbia, MO, database (1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000) found 40 accessions of hedgehogs with histopathologic exam. Sixty-three percent of the cases were nonneoplastic, 37% were neoplastic. This report describes the morphologic and immunohistochemical features of 3 spindle cell sarcomas in 2 African hedgehogs. Case no. 1 was a 4.5-month-old female African hedgehog, which developed a mass on the medial aspect of the right foreleg. The hedgehog was euthanized at the owner's request. The 3-cm-diameter mass and multiple organs were collected by the referring veterinarian for histopathologic examination at the VMDL. Case no. 2 was a 3-year-old female African hedgehog with a mass in the right lumbar skin and another mass in the vagina, which were excised and sent to the VMDL for histopathologic examination.Tissues were fixed for an undetermined period in 10% buffered formalin and embedded in paraffin. Five-micrometer sections were stained with HE and Masson trichrome. For immunohistochemistry, paraffin sections were placed on positively charged slides and stained with antibodies to vimentin, a smooth muscle-specific actin, a muscle-specific actin, a desmin, a CD10, b S100 protein, a neuron-specific enolase, a chromogranin A, a synaptophysin, a glial fibrillary acidic protein, a and factor VIII-related antigen a following described methods. 18 Immunohistochemical staining was performed in From the Veterinary

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Haematopoietic malignancies in zoo animals

Cited by 49 publications

References 3 publications

Presumptive granulocytic leukemia in a hognose snake (Heterodon platirhinos)

Presumptive granulocytic leukemia in a hognose snake (Heterodon platirhinos)

Lymphoblastic Lymphoma and Leukemic Blood Profile in a Red-Tail Boa (Boa Constrictor Constrictor) with Concurrent Inclusion Body Disease

Soft Tissue Sarcomas in the African Hedgehog (Atelerix Albiventris): Microscopic and Immunohistologic Study of Three Cases

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