HAEMOcare: The First International Epidemiological Study Measuring Burden of Hemophilia in Developing Countries

Gupta, Naresh; Benbouzid, Abderrahmane; Belhani, M; Andaloussi, M. El; Maani, K.; Wali, Yasser; Fegoun, Soraya Benchikh El; Saad, Hossam; Mahlangu, Johnny

doi:10.1055/s-0039-1688414

Cited by 21 publications

(22 citation statements)

References 23 publications

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“…In that study, 70% of patients being treated on-demand reported limitations on the Hemophilia Joint Health Score (HJHS) from haemophilia-related orthopaedic morbidities. 3 In a study conducted in Algeria, 61% of patients required surgical intervention due to joint disease and the majority of the surgical intervention was carried out before 30 years of age. 14% of the overall surgeries were joint replacement surgeries with the youngest patient being 11 years of age.…”

Section: Arthroplasty In Haemophilia: Double-edged Sword In Low/ Middmentioning

confidence: 99%

“…The HAEMOcare study conducted in five developing countries reported 84% of patients had target joints with a mean annual bleeding rate of 26%, which is significantly higher compared to developed countries. In that study, 70% of patients being treated on‐demand reported limitations on the Hemophilia Joint Health Score (HJHS) from haemophilia‐related orthopaedic morbidities 3 . In a study conducted in Algeria, 61% of patients required surgical intervention due to joint disease and the majority of the surgical intervention was carried out before 30 years of age.…”

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Arthroplasty in haemophilia: Double‐edged sword in low/middle‐income countries

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Section: Arthroplasty In Haemophilia: Double-edged Sword In Low/ Middmentioning

confidence: 99%

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Arthroplasty in haemophilia: Double‐edged sword in low/middle‐income countries

et al. 2020

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“…Therefore, we must carefully check and confirm the validity of the KK regularization by calculating the KK corrections with another regularization method. In order to avoid the above ambiguity of the KK regularization, we regularize the 4-momentum integrals by the method of dimensional regularization before summing all the KK states, following the paper [36]. Now, we define the proper time integral I n as follows:…”

Section: B Casimir Corrections For the Higgs Mass With Dimensional Rmentioning

confidence: 99%

Revisiting regularization with Kaluza-Klein states and Casimir vacuum energy from extra dimensional spaces

Matsui

Matsumoto²

2019

Phys. Rev. D

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In the present paper, we investigate regularization of the one-loop quantum corrections with infinite Kaluza-Klein (KK) states and evaluate Casimir vacuum energy from extra dimensions. The extra dimensional models always involve the infinite massless or massive Kaluza-Klein states, and therefore, the regularization of the infinite KK corrections is highly problematic. In order to avoid the ambiguity, we adopt the proper time integrals and the Riemann zeta function regularization in evaluating the summations of infinite KK states. In the calculation, we utilize the KK regularization method with exchanging the infinite summations and the infinite loop integrals. At the same time, we also evaluate the correction by the the dimensional regularization method without exchanging the summations and the loop integrals. Then, we clearly show that the regularized Casimir corrections from the KK states have the form of ∝ 1/R 2 for the Higgs mass and ∝ 1/R 4 for the cosmological constant, where R is the compactification radius. We also evaluate the Casimir energy in supersymmetric extra-dimensional models. The contributions from bulk fermions and bulk bosons are not offset because we choose SUSY breaking boundary conditions. The non-zero supersymmetric Casimir corrections from extra dimensions undoubtedly contribute to the Higgs mass and the cosmological constant. We conclude the coefficients of such corrections are enhanced compared to the case without bulk supersymmetry. * hiroki.matsui.c6@tohoku.ac.jp † yoshio@cc.miyakonojo-nct.ac.jp 1 Many new physics models have been considered [10-12] until now but there are no obvious solutions.

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“…Optimal management for people with severe haemophilia involves prophylaxis with regular infusions of FVIII or FIX, which helps to reduce the risk of bleeds and joint damage [3] . However, this is expensive and frequently not an option in economically developing countries, where people with haemophilia (PwH) more commonly receive on-demand treatment with factor replacement only when bleeding occurs [4][5] . Children and adults with mild or moderate haemophilia also receive on-demand treatment.…”

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A multi-country snapshot study of pain in people with haemophilia

Mulders

Thykjaer²,

Khair³

2020

The Journal of Haemophilia Practice

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IntroductionPeople with haemophilia (PwH) experience recurrent bleeds in weight-bearing joints. Optimal management for people with severe haemophilia involves prophylaxis with factor VIII or IX, which helps to reduce the risk of bleeds and joint damage. However, this is expensive and frequently not an option in economically developing countries, where on-demand treatment is more commonly used as bleeding occurs. PwH with moderate and mild haemophilia are also treated on demand. Pain from bleeds and arthropathy is common in PwH; it is recognised as a burden that impairs quality of life and can be challenging to manage.AimsThis study aims to establish greater understanding of the experience of pain in PwH in different countries, the factors that influence this, and how pain is currently managed.MethodsPwH attending haemophilia treatment centres (HTCs) completed an anonymous questionnaire about their experience of pain and pain-relief within the previous 28 days (up to 10 PwH per participating HTC).Results209 PwH from 20 HTCs in 11 countries participated in the study. The median age was 36 (range 8–84); 181 (86.6%) had haemophilia A, 25 (12.0%) haemophilia B, and three (1.4%) did not know; 148 (70.8%) had severe haemophilia, 28 (13.4%) moderate, and 31 (14.8%) mild. Twenty-eight (13.4%) had an inhibitor. The majority (n=121; 57.9%) were on prophylaxis; 61 (29.2%) were treated on demand; 20 (9.6%) used a combination; 7 (3.3%) did not know. 154 PwH (73.9%) experienced a total of 1,945 days of pain with severity on a visual analogue scale reported as 4.5. The most commonly reported sites of pain were joints and muscles. There was no significant difference in pain incidence between countries. Children aged less than 16 years reported the lowest amount of pain, with reported pain increasing with age in older respondents. Simple analgesia such as paracetamol was used but participants reported that it did not relieve pain. Alternative pain-relief strategies including rest, physiotherapy, walking aids, alcohol or marijuana were also used with varying effect.ConclusionsPain is common among PwH and increases with age. Age and developmentally appropriate pain assessment should be a part of routine haemophilia care.

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HAEMOcare: The First International Epidemiological Study Measuring Burden of Hemophilia in Developing Countries

Cited by 21 publications

References 23 publications

Arthroplasty in haemophilia: Double‐edged sword in low/middle‐income countries

Arthroplasty in haemophilia: Double‐edged sword in low/middle‐income countries

Revisiting regularization with Kaluza-Klein states and Casimir vacuum energy from extra dimensional spaces

A multi-country snapshot study of pain in people with haemophilia

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