Hæmodlalysis in Paracetamol Self-Poisoning

Farid, Nahla; Glynn, J. P.; Kerr, David

doi:10.1016/s0140-6736(72)91794-1

Cited by 54 publications

(5 citation statements)

References 8 publications

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“…The stated interval between poisoning and presentation was more than 1, 2, 4, 8 or 15 h in 247 (61%), 162 (40%), 86 (21%), 42 (11%) and 16 (4%) cases respectively and unknown in 53 (13%). Two overdoses were staggered over several hours.…”

Section: Resultsmentioning

confidence: 96%

Paracetamol poisoning in the North East of England: presentation, early management and outcome

et al. 1997

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1 Paracetamol is increasingly involved in self-poisoning in the United Kingdom and remains a common cause of fatal poisoning. 2 To document the epidemiology and early management of paracetamol poisoning data were collected on consecutive patients with suspected paracetamol poisoning presenting to 6 hospitals in the North East of England over 12 weeks in 1994. 3 There were 400 presentations (attendance rate 1.14/103 population/yr) involving 343 persons (45% male). Paracetamol concentrations at 4 h correlated weakly with reported paracetamol dose (R=0.49, P < 0.0001) and were similar comparing those treated and not treated by gastric decontamination. 4 In 38 (9%) cases paracetamol concentrations were above the appropriate nomogram treatment line, including 3% and 20% of patients who reported ingesting less than and more than 12 g respectively. In 21 patients acetylcysteine treatment was deferred until admission to the ward, the mean delay involved was 2.8 h. 5 One patient died, from arrhythmias caused by co- ingested dothiepin. 6 Paracetamol poisoning is common. Most cases do not have potentially toxic plasma paracetamol concentra tions, but those who do often present late and antidotal treatment may be delayed inappropriately.

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Section: Resultsmentioning

confidence: 96%

Paracetamol poisoning in the North East of England: presentation, early management and outcome

et al. 1997

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“…9,10 Several reports demonstrate that acetaminophen can be removed by hemodialysis. [11][12][13][14] However, there are few case reports describing the use of hemodialysis for acute acetaminophen overdose. Pond described a patient who presented late after an estimated 58 g acetaminophen ingestion.…”

Section: Discussionmentioning

confidence: 99%

Massive acetaminophen ingestion with early metabolic acidosis and coma: treatment with IV NAC and continuous venovenous hemodiafiltration

Wiegand

Margaretten

Olson

2010

Clinical Toxicology

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“…Acet aminophen in infusions may evoke an aller gic reaction in susceptible recipients [1], sim ilar to that of penicillin-or aspirin-contain ing blood [2,3], The platelets are among the blood components which may be seriously affected by the donor's intake of acetamino phen. While aspirin may interfere with nor mal platelet function, consumption of a reg ular dose of acetaminophen has been re ported to induce thrombopenia [4], Al though considered a relatively harmless drug, overdoses of acetaminophen may cause serious poisoning which may even result in fatal liver or renal injury [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%