Haemodynamic Advantages of Isosorbide Dinitrate Over Frusemide in Acute Heart-Failure Following Myocardial Infarction

Nelson, G.; Ahuja, Ramesh C.; Silke, Bernard; Hussain, M.; Taylor, Stanley H.

doi:10.1016/s0140-6736(83)92025-1

Cited by 100 publications

(34 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Fifteen RCTs (869 patients) were found that satisfied the inclusion criteria [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] ( Table 2). Two trials were placebo controlled.…”

Section: Resultsmentioning

confidence: 99%

“…10,12,17,18 Seven trials included exclusively patients with acute pulmonary oedema. 10,12,14,17,20,21,23 One trial included exclusively patients with hypertensive encephalopathy. 16 There was no trial that included exclusively patients with acute aortic dissection or acute myocardial infarction.…”

Section: Resultsmentioning

confidence: 99%

“…Mortality was reported in seven trials 9,10,14,16,17,20,21 and totalled six deaths in three RCTs. The group to which the dead patients were originally allocated was not reported for five of the Figure 1 Quorum flowchart of studies.…”

Section: Resultsmentioning

confidence: 99%

“…Three trials compared nitrates to diuretics (Beltrame, Nelson and Verma) 10,17,21 . Furosemide was the common diuretic used in all of them with two nitrates, nitroglycerine and isosorbide as comparators.…”

Section: Non-fatal Cardiovascular Eventsmentioning

confidence: 99%

See 3 more Smart Citations

Pharmacological interventions for hypertensive emergencies: a Cochrane systematic review

Perez

Musini

2008

J Hum Hypertens

View full text Add to dashboard Cite

Hypertensive emergencies occur when high blood pressure is associated with the presence of acute endorgan damage, such as hypertensive encephalopathy. There is controversy as to when and which antihypertensive drugs to use in these situations. Using a comprehensive search strategy in electronic sources, MEDLINE, EMBASE and Cochrane clinical trial register, we conducted a systematic review to look all randomized control trials (RCTs) that compare an antihypertensive drug versus placebo, no treatment or another antihypertensive drug. Fifteen RCTs (representing 869 patients) met the inclusion criteria. Two trials included a placebo arm. All studies (except one) were open-label trials. Seven drug classes were evaluated in those trials: nitrates (nine trials), angiotensin-converting enzyme inhibitors (seven), diuretics (three), calcium channel blockers (six), a-1 adrenergic antagonists (four), direct vasodilators (two) and dopamine agonists (one). Mortality event data were reported in seven trials. Due to insufficient data, no meta-analysis was performed for clinical outcomes. Differences in blood pressure changes between antihypertensives were minor. There is no RCT evidence demonstrating that antihypertensive drugs reduce mortality or morbidity in patients with hypertensive emergencies. Furthermore, there is insufficient RCT evidence to determine which drug or drug class is most effective in reducing mortality and morbidity. There were some minor differences in the degree of blood pressure lowering when one class of antihypertensive drug is compared to another. However, the clinical significance is unknown. RCTs are needed to assess different drug classes to determine initial and longer-term mortality and morbidity outcomes.

show abstract

“…Fifteen RCTs (869 patients) were found that satisfied the inclusion criteria [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] ( Table 2). Two trials were placebo controlled.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Non-fatal Cardiovascular Eventsmentioning

confidence: 99%

See 2 more Smart Citations

Pharmacological interventions for hypertensive emergencies: a Cochrane systematic review

Perez

Musini

2008

J Hum Hypertens

View full text Add to dashboard Cite

show abstract

“…Recent studies 124,[205][206][207] showed that the most important predictor of immediate therapeutic success (measured as oxygen saturation >95% in 60 min) was the capacity to reduce arterial blood pressure by 15-30% in 15-30 min. This represents a decrease of systemic vascular resistance, which confirms the importance of rapid arterial dilation as a primary objective in the treatment of APE.…”

Section: Furosemide and Morphine Have Long Been Considered As Thementioning

confidence: 99%