Haemodynamic effects of a new beta-blocking agent 'Sectral' (M &amp; B 17803A).

Lewis, Basil S.; Bakst, Alvin A.; Mitha, Abdul S.; Purdon, K.; Gotsman, Mervyn S.

doi:10.1136/hrt.35.7.743

Cited by 31 publications

(8 citation statements)

References 17 publications

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“…These apparent discrepancies could be attributed to the haemodynamic effects of acute doses of these drugs. Thus propranolol is likely to cause greater reduction of cardiac output with arterial vasoconstriction than acebutolol (Gibson, 1974;Lewis et al, 1973;Basil et al, 1973) and changes in testicular blood flow are known to influence Leydig cell response to gonadotrophins (Eik-Nes, 1964). These haemodynamic differences may also explain the observation that propranolol increased cortisol revels whereas acebutolol did not.…”

Section: Discussionmentioning

confidence: 99%

The effects of propranolol and acebutolol on the overnight plasma levels of anterior pituitary and related hormones.

Mj¹,

Groom²,

Barber³

et al. 1981

Brit J Clinical Pharma

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1 The effects of single evening doses of the beta‐adrenoceptor blocking agents propranolol (80 mg orally) and acebutolol (200 mg orally) on plasma levels throughout the night of prolactin, growth hormone, luteinising hormone, follicle stimulating hormone, cortisol and testosterone have been studied in seven healthy male volunteers. 2 Three way analysis of variance showed that acebutolol significantly reduced circulating levels of prolactin and follicle stimulating hormone, but did not alter the levels of the other hormones studied. 3 Propranolol significantly reduced follicle stimulating hormone and testosterone, and significantly increased circulating levels of cortisol, but caused no change in the other hormones studied. 4 Prolactin, luteinising hormone, testosterone and cortisol showed a significant variation with time indicating the existence of a diurnal rhythm in the pattern of their secretion. 5 There was a significant inter‐subject variability in all the hormones studied. 6 There was a significant between‐subject variation in response to both propranolol and acebutolol. 7 Different subjects showed significant variations with respect to time in prolactin, growth hormone and cortisol levels. 8 Neither propranolol nor acebutolol significantly altered the time course of secretion of any of the hormones studied. 9 Possible relationships of these beta‐adrenoceptor blocker‐induced changes in anterior pituitary and related hormones to the antihypertensive mechanism of acebutolol and propranolol are discussed.

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Section: Discussionmentioning

confidence: 99%

The effects of propranolol and acebutolol on the overnight plasma levels of anterior pituitary and related hormones.

Mj¹,

Groom²,

Barber³

et al. 1981

Brit J Clinical Pharma

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“…Acebutolol is a cardioselective beta-blocking drug with one-quarter to one-seventh the beta-blocking potency of propranolol (Lewis et al, 1973). It also possesses intrinsic sympathomimetic activity.…”

Section: Discussionmentioning

confidence: 99%

Haemodynamic effects of acute beta-adrenergic receptor blockade in congestive cardiomyopathy.

Ikram¹,

Chan²,

Bennett³

et al. 1979

Heart

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SUMMARY Acebutolol ('Sectral'), a cardioselective beta-blocking drug, was administered intravenously in a dose of 25 mg to 10 patients with congestive cardiomyopathy. All of them were in a stable condition on antifailure regimens. The drug resulted in a statistically significant decline in left ventricular contractility as judged by peak left ventricular dP/dT and the contractility index. The mean aortic blood pressure also fell. There was a significant increase in end-diastolic and end-systolic left ventricular volumes.Mean values for heart rate, ejection fraction, left ventricular stroke work index, and cardiac output also fell, but the results were not statistically significant. Left ventricular distensibility as judged by the slope of the diastolic pressure-volume relation also improved significantly.A reduction in myocardial energy requirements, improved compliance, and lowering of arterial pressure would be haemodynamically advantageous. However, further cardiac dilatation and reduction in contractility-the basic defects in congestive cardiomyopathy-could lead to further deterioration.

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“…In a previous study we showed that acebutolol is well tolerated orally and is effective in reducing the frequency of premature ventricular contractions in patients with drug-resistant ventricular arrhythmias (Gradman et al, 1975). The haemodynamic effects of acebutolol in man were the subject of a previous study in which a small dose of 30 mg was used (Lewis et al, 1973b). In the present study we examined the haemodynamic effects in man of acebutolol in a dose of 1*0 mg/kg body weight, because this larger dose yields plasma concentrations in the therapeutic range (Gradman et al, 1975).…”

mentioning

confidence: 96%

Haemodynamic effects of acebutolol.

Mason¹,

Specter²,

Ingels³

et al. 1978

Heart

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We studied the haemodynamic effects of acebutolol, administered in intravenous doses of 0 5 mg/kg and 1 0 mg/kg body weight, in 7 patients who had undergone coronary artery bypass surgery and in 4 Acebutolol is a new beta-adrenoreceptor blocking agent which is effective in the management of angina pectoris as well as hypertension (Lewis et al., 1973a). As a beta-antagonist, it is approximately one-eighth as potent as propranolol. Acebutolol exerts a membrane stabilising effect similar to that of propranolol, but has somewhat greater cardioselectivity (Kumana et al., 1975). In a previous study we showed that acebutolol is well tolerated orally and is effective in reducing the frequency of premature ventricular contractions in patients with drug-resistant ventricular arrhythmias (Gradman et al., 1975). The haemodynamic effects of acebutolol in man were the subject of a previous study in which a small dose of 30 mg was used (Lewis et al., 1973b). In the present study we examined the haemodynamic effects in man of acebutolol in a dose of 1*0 mg/kg body weight, because this larger dose yields plasma concentrations in the therapeutic range (Gradman et al., 1975). We investigated left ventricular dynamics by a new method in which the motion of surgically implanted myocardial markers is recorded fluoroscopically and the

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Haemodynamic effects of a new beta-blocking agent 'Sectral' (M & B 17803A).

Abstract: The haemodynamic effects of a new beta-blocking agent, 'Sectral' (M & B I78o3A)

Cited by 31 publications

References 17 publications

The effects of propranolol and acebutolol on the overnight plasma levels of anterior pituitary and related hormones.

The effects of propranolol and acebutolol on the overnight plasma levels of anterior pituitary and related hormones.

Haemodynamic effects of acute beta-adrenergic receptor blockade in congestive cardiomyopathy.

Haemodynamic effects of acebutolol.

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