2013
DOI: 10.5455/2319-2003.ijbcp20130105
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Haemodynamic effects of intrathecal dexmedetomidine added to ropivacaine intraoperatively and for postoperative analgesia

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Cited by 20 publications
(15 citation statements)
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“…It reduces opioids and inhalational anesthetic requirement and have been widely used for Intensive Care Unit sedation with hemodynamic stability. [ 3 ]…”
Section: Introductionmentioning
confidence: 99%
“…It reduces opioids and inhalational anesthetic requirement and have been widely used for Intensive Care Unit sedation with hemodynamic stability. [ 3 ]…”
Section: Introductionmentioning
confidence: 99%
“…Early onset of analgesia, prolonged analgesia and sedation effect of dexmedetomidine is due to its highly selective α2 agonistic affinity and its greater lipid solubility helps in easy penetration. The synergistic action of dexmedetomidine [7] with local anaesthetics is because they cause hyperpolarisation of nerve tissues at the level of locus coeruleus in the brain stem. The analgesic effect of dexmedetomidine is due to inhibition of release of substance P in the nociceptive pathway and also inhibits the release of norepinephrine at the nerve endings.…”
Section: Discussionmentioning
confidence: 99%
“…It prolongs the sensory block by acting on presynaptic C fibers and decrease the neurotransmitter release, it prolongs the motor block by binding to motor neurons in the spinal cord [10,11].…”
Section: Introductionmentioning
confidence: 99%