Haemodynamic effects of metoprolol and pindolol: a comparison in hypertensive patients.

Svensson, Anders; Gudbrandsson, Thorkell; Sivertsson, Ramon; Hansson, Lennart

doi:10.1111/j.1365-2125.1982.tb01923.x

Cited by 52 publications

(15 citation statements)

References 32 publications

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“…These findings were confirmed in an extended doubleblind comparison of pindolol and metoprolol given to 36 hypertensive patients (Svensson et al, 1982). This study not only suggested that pindolol lowered blood pressure mainly through a vasodilating action, which was attributable to its marked ISA, and that metoprolol lowered blood pressure mainly via cardiac mechanisms (Figure 2).…”

Section: Treatment Of Hypertension With F-adrenoceptor Blockerssupporting

confidence: 65%

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ISA‐vasodilatation: improvement of organ perfusion.

Hansson¹

1987

Brit J Clinical Pharma

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1. In almost all forms of established hypertension the increase in blood pressure can be attributed to increased total peripheral vascular resistance. 2. beta‐adrenoceptor blocking compounds, which are frequently used as first‐line therapy in hypertension, may compromise blood flow to vital organs in view of the fact that they reduce cardiac output both acutely and during long‐term treatment. 3. beta‐ adrenoceptor blocking agents with a marked intrinsic sympathomimetic activity (ISA) such as pindolol differ in this respect by lowering arterial pressure without lowering cardiac output while causing a reduction in total peripheral resistance. 4. Direct vascular effects of beta‐adrenoceptor blockers with marked ISA could contribute to the normalisation of hypertension‐induced structural arteriolar changes. The effect appears to be dissociated from the effect caused by the lowering of blood pressure per se.

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Section: Treatment Of Hypertension With F-adrenoceptor Blockerssupporting

confidence: 65%

“…Since the antihypertensive effect was similar during treatment with pindolol and metoprolol, it is obvious that the reversibility of structural vascular changes seen during treatment with pindolol must be attributed to a factor other than the antihypertensive effect. The most Svensson et al, 1982).…”

Section: Treatment Of Hypertension With F-adrenoceptor Blockersmentioning

confidence: 99%

ISA‐vasodilatation: improvement of organ perfusion.

Hansson¹

1987

Brit J Clinical Pharma

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“…A decrease has been shown in the regional flow resistance of the hand at maximal vasodilatation after long term hypotensive treatment . with its intrinsic sympathomimetic activity seems, to some extent, to act through peripheral vascular mechanisms (Atterhog et al, 1977;Svensson et al, 1982). In the studies reviewed here the peripheral vascular resistance at maximal vasodilatation decreased after long term treatment with pindolol.…”

Section: Mechanism Of Hypotensive Effect Of Pindololmentioning

confidence: 82%

Reversibility of structural changes in the resistance vessels in hypertension: a review of studies with pindolol.

Dunér

1987

Brit J Clinical Pharma

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1. In recent years evidence has accumulated which indicates that although various beta‐adrenoceptor antagonists are equally effective in lowering blood pressure in patients with essential hypertension the mechanisms of action of the different drugs are heterogeneous. 2. Pindolol, a beta‐adrenoceptor antagonist with pronounced intrinsic sympathomimetic activity (ISA) appears, to some extent, to act via peripheral vascular mechanisms. 3. Following prolonged treatment with pindolol in essential hypertension peripheral vascular resistance at maximal vasodilatation has been found to be decreased compared with the pretreatment values suggesting that the structural vascular changes characteristic of established hypertension may be reversible.

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“…35 Thus, factors other than blood pressure must also play a role in the determination of cardiovascular structure.…”

Section: Hypotensive Action Of Hydralazinementioning

confidence: 99%

Cardiac mass and peripheral vascular structure in hydralazine-treated spontaneously hypertensive rats.

Jespersen¹,

Nyborg²,

Pedersen³

et al. 1985

Hypertension

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SUMMARYWe have examined the effect of antihypertensive treatment on heart weight and on structural and functional characteristics of isolated mesenteric resistance vessels (internal diameter 170-220 fun) in spontaneously hypertensive rats (SHR) and in Wistar-Kyoto rats (WKY). The SHR and WKY were treated with hydralazine from the age of 4 weeks and were examined at ages 12 to 14 weeks and 23 to 27 weeks. Treated SHR had a mean blood pressure as much as 29% below that of control WKY, which in turn was 25 to 40% less than that of control SHR. In 12-to 14-week-old rats the heart to body weight ratio (which in control SHR was 13% greater than that of WKY) was unaffected by treatment. Thereafter, the heart to body weight ratio of treated SHR did not increase as much as usual. At both ages, the media thickness and contractile response of the resistance vessels of the SHR (which were, respectively, 37% and 30% greater than those of vessels of WKY) were unaffected by treatment. However, because treatment caused a small (8%) increase in the lumen diameter of the vessels of the SHR, treatment did cause small, but possibly physiologically important, decreases both in the media to lumen ratio (11 %) and in the pressure against which these vessels would have been able to contract (10%). Treatment had little effect on the pharmacological characteristics of vessels of either SHR or WKY. The results suggest that the increased heart weight, media thickness, and contractile response in mesenteric resistance vessels of SHR up to ages 23 to 27 weeks are due primarily to factors other than increased pressure.

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Haemodynamic effects of metoprolol and pindolol: a comparison in hypertensive patients.

Cited by 52 publications

References 32 publications

ISA‐vasodilatation: improvement of organ perfusion.

ISA‐vasodilatation: improvement of organ perfusion.

Reversibility of structural changes in the resistance vessels in hypertension: a review of studies with pindolol.

Cardiac mass and peripheral vascular structure in hydralazine-treated spontaneously hypertensive rats.

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