Haemodynamic effects of prenaterol and cardiac glycosides in patients with recent myocardial infarction

Abstract

Prenalterol was given to twenty five patients with acute myocardial infarction. Thirteen patients (group B) had signs of cardiac decompensation while twelve (group A) had not. Ejection fraction was determined with 99mTc-labelled red blood cells before and after prenalterol (50 micrograms kg-1 body weight), intravenously. In group B this procedure was repeated after digitalization 2 days later. The ejection fraction increased significantly in group A after prenalterol injection. In group B, prenalterol produced an increase, but this was not significant. After digitalis the ejection fraction increased significantly and prenalterol produced an additional significant rise. No significant changes in blood pressure occurred. Heart rate increased significantly in both groups after prenalterol injection and decreased significantly after digitalis.

Congestive Heart Failure in the Elderly

“…Digoxin therapy provides significant relief of symptoms and improves quality of life for a minority of patients with CHF and sinus rhythm; these patients are identified as having large, dilated ventricles, usually with an S 3 gallop, and class III or IV symptoms of CHF by New York Heart Association criteria 152 – 157 . Digoxin effects are additive to the effects of concomitantly administered vasodilators and beta‐receptor agonists 148 , 150 , 151 , 158 …”

Effect of xamoterol on exercise capacity and left ventricular function in angina pectoris and in dilated cardiomyopathy

“…The β 1 ‐stimulating property of xamoterol at rest has been shown to increase the left ventricular performance in acute studies among patients with impaired left ventricular function [4, 5]. An increase in left ventricular performance has also been shown in digitalized patients after short‐term treatment with the β 1 ‐stimulating drug prenalterol [14, 15]. In the cardiomyopathy patients 4 weeks of xamoterol treatment caused an increased left ventricular performance shown as increased global ejection fraction at rest caused by a general regional improvement at rest, both among the patients with and without digitalis.…”

The use of digitalis for the treatment of congestive heart failure: A tale of its decline and resurrection

“…Digoxin added to nifedipine [18] or nitroprusside [19] caused an increase in cardiac index as well as a further lowering of left ventricular end-diastolic pressure. The increase in the radionuclide-assessed ventricular ejection fraction was observed when digoxin was given to patients with heart failure, a mean of 9 days after an acute myocardial infarction was further augmented by prenalterol, a beta~ partial agonist [21]. The increase in the radionuclide-assessed ventricular ejection fraction was observed when digoxin was given to patients with heart failure, a mean of 9 days after an acute myocardial infarction was further augmented by prenalterol, a beta~ partial agonist [21].…”