Haemodynamic Effects of Salbutamol in Patients Needing Circulatory Support after Open-heart Surgery

Wyse, S D; Gibson, D G; Branthwaite, M. A.

doi:10.1136/bmj.3.5929.502

Cited by 19 publications

(3 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Salbutamol, a f2-adrenergic receptor agonist has been shown to improve left ventricular function in patients with acute low cardiac output syndromes (Lal, Savidge, Davies Ali & Soni, 1972;Yacoub & Boyland, 1973;Wyse, Gibson & Branthwaite, 1974) and chronic congestive cardiac failure (Sharma, Goodwin & Steiner, 1977). This agent has a relatively prolonged duration of action after intravenous administration which is a disadvantage in the management of acutely ill patients with cardiac failure.…”

Section: Introduction Methodsmentioning

confidence: 99%

Comparative peripheral and coronary haemodynamic effects of rimiterol and isoprenaline.

Stephens¹,

Hayward²,

Ead³

et al. 1978

Brit J Clinical Pharma

View full text Add to dashboard Cite

I Rimiterol and isoprenaline produced significant dose-related increases in cardiac output. 2 These changes in cardiac output were accompanied by increases in heart rate and myocardial oxygen consumption which were similar for each drug and dose-related. 3 Isoprenaline in contrast with rimiterol produced direct coronary vasodilation, i.e. coronary vasodilation in excess of that required to meet increases in myocardial oxygen demands.4 It is suggested that the P-adrenergic receptors in the human coronary vasculature are mainly of the /5, type.

show abstract

Section: Introduction Methodsmentioning

confidence: 99%

Comparative peripheral and coronary haemodynamic effects of rimiterol and isoprenaline.

Stephens¹,

Hayward²,

Ead³

et al. 1978

Brit J Clinical Pharma

View full text Add to dashboard Cite

show abstract

“…2~3 In humans, hemodynamic benefits were described in patients with congestive heart failure complicating acute myocardial infar~tion.~-~ and in patients after surgery. [8][9][10] There is a relative paucity of data regarding the effects of salbutamol in patients with chronic heart failure. Also, controversy still exists as to the anhythmogenic potential of the drug in patients with left ventricular dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Acute hemodynamic and arrhy thmogenic effects of high‐dose intravenous salbutamol in patients with chronic left ventricular dysfunction

Rotstein

Battler

Rath

et al. 1990

Clinical Cardiology

View full text Add to dashboard Cite

Summary:The short-term hernodynamic and possible arrhythmogenic effects of intravenous salbutamol at a dose of 30 or 60 pglmin were evaluated in 14 patients with severe chronic left ventricular dysfunction using equilibrium radionuclide angiocardiography and electrocardiographic monitoring. Salbutamol infusions at a dose of 30 pg/min did not cause significant hernodynamic changes; however, at a dose of 60 pg/min there was a significant increase in stroke volume, cardiac output, and left ventricular ejection fraction. Heart rate increased significantly while systemic peripheral resistance decreased significantly. Two patients developed ventricular premature beats and another two supraventricular tachycardia, but none were associated with adverse consequences. Thus, highdose intravenous salbutamol is effective and safe, and may be used in the acute management of patients with poor left ventricular function.

show abstract

“…Received for publication 24 January 1977 vocated for use after cardiac operations. Yacoub and Boyland (1973) reported the effects of a single intravenous dose and Wyse et al (1974) compared the effects of continuous intravenous infusions of salbutamol and isoprenaline but gave no details of the basal haemodynamic state of their patients before administration of the drug.…”

mentioning

confidence: 99%

Haemodynamic effects of salbutamol and nitroprusside after cardiac surgery.

Poole-Wilson¹,

Lewis²,

Angerpointer³

et al. 1977

Heart

View full text Add to dashboard Cite

The haemodynamic effects of a continuous intravenous infusion of salbutamol (15 to 30 'g/min) and nitroprusside (50 to 100 tug/min) were compared in 9 patients after cardiac surgical operations. The mean falls in left atrial pressure and systemic vascular resistance were similar with the two drugs but salbutamol caused a greater increase in heart rate, maximum acceleration of aortic bloodflow, and maximum rate of change of left ventricular power. Because these differences would cause greater myocardial oxygen consumption with salbutamol and because the infusion of salbutamol is less easily controlled, nitroprusside is the preferred drug after cardiac operations.Drugs that cause vasodilatation and consequently a reduction in systemic vascular impedance (left ventricular afterload) have recently been advocated in a variety of circumstances in which cardiac function is abnormal. Advantageous effects have been reported in patients with acute myocardial infarction (Chatterjee et al., 1973), chronic ischaemic heart disease (Miller et al., 1975), refractory heart failure (Guiha et al., 1974), mitral regurgitation and stenosis (Goodman et al., 1974;Bolen et al., 1975), and cardiomyopathy (Rossen et al., 1976 The present study was undertaken to measure the haemodynamic changes during a continuous intravenous infusion of salbutamol in patients soon after cardiac operations. A comparison was made with the effects of an infusion of nitroprusside because this drug has previously been recommended in similar circumstances (Stinson et al., 1975). MethodsNine patients (7 male, 2 female; age range 36 to 64 years, mean 51 years) were studied. Five had aortocoronary bypass grafts inserted and 2 had had aortic and 2 mitral valve replacement. The patients were unselected consecutive surgical candidates in whom preoperative catheterisation had excluded left ventricular dyskinesia or valve disease other than that for which the operation was being performed. The exact nature of the investigation was explained to the patients in order to obtain informed consent.The study began 24 to 36 hours after operation, at a time when the patients could be maintained for several hours in quiet undisturbed circumstances. During this period no additional drugs were given.One patient was receiving an inotropic agent (iso.

show abstract

Haemodynamic Effects of Salbutamol in Patients Needing Circulatory Support after Open-heart Surgery

Cited by 19 publications

References 4 publications

Comparative peripheral and coronary haemodynamic effects of rimiterol and isoprenaline.

Comparative peripheral and coronary haemodynamic effects of rimiterol and isoprenaline.

Acute hemodynamic and arrhy thmogenic effects of high‐dose intravenous salbutamol in patients with chronic left ventricular dysfunction

Haemodynamic effects of salbutamol and nitroprusside after cardiac surgery.

Contact Info

Product

Resources

About