Haemodynamics in women with untreated pre‐eclampsia*

Abstract

SummaryThis study aimed to compare the haemodynamics in healthy pregnant women with the haemodynamics in women with untreated pre-eclampsia, to determine the cardiovascular reason for hypertension in pre-eclampsia. 40 women with untreated pre-eclampsia, 40 matched healthy pregnant women and 20 non-pregnant women were studied using transthoracic echocardiography. Untreated pre-eclampsia demonstrated (mean (SD), healthy non-pregnant vs healthy pregnant vs untreated pre-eclampsia) increased cardiac output (3400 (752) vs 4109 (595) vs 4789 (1416) ml.min Pre-eclampsia is a significant multiple organ system disease of pregnancy [1]. Hypertension is the defining clinical feature [2][3][4], but the haemodynamic explanation for hypertension in pre-eclampsia is still controversial.Hypertension is determined by cardiac output and systemic vascular resistance. Although previous studies have examined aspects of the cardiovascular system in healthy pregnant women and in women with

Echocardiographic Structure and Function in Hypertensive Disorders of Pregnancy

“…27,38,40,53,57 Interestingly E/e′ was shown to be significantly higher in an early-onset preeclampsia subgroup compared with a late-onset subgroup. 40 One study used a composite of diastolic indices to diagnose diastolic dysfunction and demonstrated diastolic dysfunction in 40% of pregnancies complicated by preeclampsia at term, compared with 14% of controls.…”

“…The use of different calculations (based either on Doppler or volume calculation) is likely to contribute to the disparity for this parameter. There was similar variability with regard to LV ejection fraction, with the majority of studies showing no significant difference compared with normotensive pregnant women 30,38,52,56,57 and only 1 showing a decrease. 33 Myocardial performance index was reduced in a study of women with preeclampsia and fetal growth restriction in the third trimester.…”

“…[22][23][24] The majority of studies (n=20) were of women with preeclampsia. 23,[26][27][28][29][30]33,38,[40][41][42]44,[50][51][52][53][55][56][57] There were 9 studies assessing GH only 24,32,35,37,39,43,48,49,54 and 7 studies evaluating both GH and preeclampsia. 22,25,31,34,36,43,45 All investigators recruited women during antenatal visits to hospital.…”

“…26 Because of the factors discussed, cardiac output in preeclampsia has been shown to be both lower 29,30,34,38,42,50 and higher 25,26,38,43,51 than normotensive pregnancies. The variation in cardiac output is shown in Table V in the Data Supplement, which also indicates its derivation.…”

Assessment of the water sectors of organism before birth in pregnant women with normal pregnancy

“…Під час вагітності спостерігаються певні зміни розподілу рідини в організмі жінок, які в більшій мірі торкаються позаклітинного простору і обумов-люються забезпеченням потреб для росту і розвит-ку плода [6]. У нормі вміст рідини у вагітних жі-нок в середньому складає 65-70 % маси тіла, з яких 6-8 % приходиться на внутрішньосудинний сектор, 15 % -на інтерстиціальний і 40-50 % -на внутріш-ньоклітинний простір.…”