Haemoglobin A1c even within non-diabetic level is a predictor of cardiovascular disease in a general Japanese population: the Hisayama Study

Ikeda, Fumie; Doi, Yasufumi; Ninomiya, Toshiharu; Hirakawa, Yoichiro; Mukai, Naoko; Hata, Jun; Shikata, Kentaro; Yoshida, Daigo; Matsumoto, Takayuki; Kitazono, Takanari; Kiyohara, Yutaka

doi:10.1186/1475-2840-12-164

Cited by 58 publications

(51 citation statements)

References 39 publications

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“…Therefore, a score is necessary to improve diagnostic precision, particularly because the prevalence of non-obstructive CAD on angiography may be greater than 50% in some populations [9]. The results from a community-dwelling Japanese population suggest that HbA1c levels are an independent risk factor for CAD [13]. Another study indicated that HbA1c was an independent risk factor for the presence of severe CAD (Beta = 0.374, p < 0.001).…”

Section: Discussionmentioning

confidence: 99%

Hemoglobin A1c Risk Score for the Prediction of Coronary Artery Disease in Subjects with Angiographically Diagnosed Coronary Atherosclerosis

Jia

An²,

Chen³

et al. 2014

Cell Physiol Biochem

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Objective: To develop a risk score by incorporating Hemoglobin A1c(HbA1c) with traditional risk factors for the prediction of coronary artery disease (CAD) in Chinese subjects. Methods: A total of 196 consecutive subjects (131 males and 65 females) aged 38-89 years who underwent coronary angiography were enrolled in this study. HbA1c risk score sheets for the prediction of CAD were developed using age, gender and HbA1c. A receiver-operating characteristic curve analysis was used to determine the optimum cut-off levels of the HbA1c risk score for predicting CAD. Results: In the ROC curve analysis, the optimal cut-off value of the HbA1c score for predicting CAD was 5.1, with a sensitivity of 72.0% and a specificity of 75.5% (area under the curve 0.781, 95% confidence interval 0.709 to 0.854, p=0.000). Conclusions: The HbA1c score system is a simple and feasible method that can be used for the prediction of CAD. Large-scale studies are needed to further substantiate these results.

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Section: Discussionmentioning

confidence: 99%

Hemoglobin A1c Risk Score for the Prediction of Coronary Artery Disease in Subjects with Angiographically Diagnosed Coronary Atherosclerosis

Jia

An²,

Chen³

et al. 2014

Cell Physiol Biochem

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“…Hemoglobin A 1c (HbA 1c ) is widely used as a marker of average blood glucose concentrations over the preceding 2 to 3 months and it has advantages over glucose tests [7] . Some evidence indicates that high HbA 1c levels prior to surgery are strongly associated with the severity of adverse events after CABG [8] .…”

Section: Introductionmentioning

confidence: 99%

Hemoglobin A1c Levels Predicts Acute Kidney Injury after Coronary Artery Bypass Surgery in Non-Diabetic Patients

Koçoğulları

Kunt²,

Aksoy

et al. 2017

Braz J Cardiovasc Surg

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Introduction Elevated hemoglobin A1c levels in patients with diabetes mellitus have been known as a risk factor for acute kidney injury after coronary artery bypass grafting. However, the relationship between hemoglobin A1c levels in non-diabetics and acute kidney injury is under debate. We aimed to investigate the association of preoperative hemoglobin A1c levels with acute kidney injury in non-diabetic patients undergoing isolated coronary artery bypass grafting.Methods202 non-diabetic patients with normal renal function (serum creatinine <1.4 mg/dl) who underwent isolated coronary bypass were analyzed. Hemoglobin A1c level was measured at the baseline examination. Patients were separated into two groups according to preoperative Hemoglobin A1c level. Group 1 consisted of patients with preoperative HbA1c levels of < 5.6% and Group 2 consisted of patients with preoperative HbA1c levels of ≥ 5.6%. Acute kidney injury diagnosis was made by comparing baseline and postoperative serum creatinine to determine the presence of predefined significant change based on the Kidney Disease Improving Global Outcomes (KDIGO) definition.ResultsAcute kidney injury occurred in 19 (10.5%) patients after surgery. The incidence of acute kidney injury was 3.6% in Group 1 and 16.7% in Group 2. Elevated baseline hemoglobin A1c level was found to be associated with acute kidney injury (P=0.0001). None of the patients became hemodialysis dependent. The cut off value for acute kidney injury in our group of patients was 5.75%.ConclusionOur findings suggest that, in non-diabetics, elevated preoperative hemoglobin A1c level may be associated with acute kidney injury in patients undergoing coronary artery bypass grafting. Prospective randomized studies in larger groups are needed to confirm these results.

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“…HbA1c is also linearly related to the risk of CVD and diabetes in non-diabetic individuals [61,62]. The mortality curve associated with HbA1c levels is U-shaped, with the lowest death rates for values between 5.0 and 5.5% [63].…”

Section: Hba1cmentioning

confidence: 99%

Claimed effects, outcome variables and methods of measurement for health claims proposed under European Community Regulation 1924/2006 in the area of blood glucose and insulin concentrations

et al. 2018

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Most requests for authorization to bear health claims under Articles 13(5) and 14 related to blood glucose and insulin concentration/regulation presented to the European Food Safety Authority (EFSA) receive a negative opinion. Reasons for such decisions are mainly ascribable to poor substantiation of the claimed effects. In this scenario, a project was carried out aiming at critically analysing the outcome variables (OVs) and methods of measurement (MMs) to be used to substantiate health claims, with the final purpose to improve the quality of applications provided by stakeholders to EFSA. This manuscript provides a position statement of the experts involved in the project, reporting the results of an investigation aimed to collect, collate and critically analyse the information relevant to claimed effects (CEs), OVs and MMs related to blood glucose and insulin levels and homoeostasis compliant with Regulation 1924Regulation /2006. The critical analysis of OVs and MMs was performed with the aid of the pertinent scientific literature and was aimed at defining their appropriateness (alone or in combination with others) to support a specific CE. The results can be used to properly select OVs and MMs in a randomized controlled trial, for an effective substantiation of the claims, using the reference method(s) whenever available. Moreover, results can help EFSA in updating the guidance for the scientific requirements of health claims.

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Haemoglobin A1c even within non-diabetic level is a predictor of cardiovascular disease in a general Japanese population: the Hisayama Study

Cited by 58 publications

References 39 publications

Hemoglobin A1c Risk Score for the Prediction of Coronary Artery Disease in Subjects with Angiographically Diagnosed Coronary Atherosclerosis

Hemoglobin A1c Risk Score for the Prediction of Coronary Artery Disease in Subjects with Angiographically Diagnosed Coronary Atherosclerosis

Hemoglobin A1c Levels Predicts Acute Kidney Injury after Coronary Artery Bypass Surgery in Non-Diabetic Patients

Claimed effects, outcome variables and methods of measurement for health claims proposed under European Community Regulation 1924/2006 in the area of blood glucose and insulin concentrations

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