Haemoglobin

Avolio, Alberto

doi:10.1097/hjh.0b013e32835efe42

Cited by 1 publication

(1 citation statement)

References 20 publications

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“…S-nitrosation transfers thiol groups from the cysteine residues of proteins to form S-nitrosothiols and nitrosylation is able to transfer NO to a transition metal ion. Under physiological conditions, NO acts as a tonic inhibitory modulator to regulate carotid body chemosensory discharge by indirectly modifying vascular tone and oxygen delivery and/or directly modulating the excitability of the glomus cells and petrosal neurons ( 25 ). In addition, NO has a dual dose-dependent effect on carotid body chemosensory discharge ( 26 ).…”

Section: Discussionmentioning

confidence: 99%

Downregulation of nitric oxide by electroacupuncture against hypoxic-ischemic brain damage in rats via nuclear factor-κB/neuronal nitric oxide synthase

Liu

et al. 2014

Molecular Medicine Reports

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The present study aimed to investigate the role of nitric oxide (NO) against perinatal hypoxic-ischemic brain damage (HIBD) in rats by electroacupuncture (EA) and to examine its potential neuroprotective mechanism. NO content, the number of positive cells, neuronal nitric oxide synthase (nNOS) and nuclear factor-κB (NF-κB) in rat cortex cells were determined. The results demonstrated that treatment with EA significantly downregulated the NO content in the cortex cells (*P<0.05, **P<0.01, compared with the control groups) and alleviated cell damage in the cortex of rats with HIBD. The activator, S-adenosyl-L-methionine and the inhibitor, hydroxylamine of cystathionine-β-synthase (CBS), aggravated and remitted the hypoxic damage in the cortex cells, respectively. In addition, treatment with EA significantly downregulated the expression of nNOS and NF-κB in the rat cortex cells (*P<0.05, **P<0.01, compared with the control groups). The results also indicated that treatment with EA downregulated the NO content of cortical cells against HIBD via the NF-κB/nNOS pathway and further implied that the hydrogen sulfide/CBS system may be involved in the process. The present study provided a significant reference for the prevention and treatment of HIBD using the EA technique and also described a novel protective mechanism.

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Section: Discussionmentioning

confidence: 99%

Downregulation of nitric oxide by electroacupuncture against hypoxic-ischemic brain damage in rats via nuclear factor-κB/neuronal nitric oxide synthase

Haemoglobin

Cited by 1 publication

References 20 publications

Downregulation of nitric oxide by electroacupuncture against hypoxic-ischemic brain damage in rats via nuclear factor-κB/neuronal nitric oxide synthase

Downregulation of nitric oxide by electroacupuncture against hypoxic-ischemic brain damage in rats via nuclear factor-κB/neuronal nitric oxide synthase

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