Haemoglobin Levels in Early Life among Infants with and without Retinopathy of Prematurity

Pheng, Edwin; Lim, Zi Di; Tai, Evelyn Li Min; Rostenberghe, Hans Van; Shatriah, Ismail

doi:10.3390/ijerph18137054

Cited by 8 publications

(9 citation statements)

References 54 publications

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“…ROP is proliferative retinopathy occurring at the confluence of the normal vascularized retina and the peripheral avascular retina and is a significant contributor to preventable childhood blindness. [ 7 8 9 ] Low birth weight, prematurity, oxygen supplementation, a short gestational period, history of blood transfusion, respiratory distress syndrome, and sepsis are the major risk factors for the development of ROP. [ 10 11 ]…”

Section: Discussionmentioning

confidence: 99%

Role of fetal hemoglobin in the development and progression of retinopathy of prematurity in preterm infants

Prasad,

Dubey,

Kumar

et al. 2023

Indian Journal of Ophthalmology

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Purpose: The objective of this study was to find the association between fetal hemoglobin (HbF) concentration and retinopathy of prematurity (ROP) in preterm infants. Methods: In this observational, prospective, longitudinal study, a total of 410 preterm infants with <36 gestational weeks and <2.5 kg birth weight, who were attending ROP clinic in a tertiary care hospital of central India for 1 year duration were included. Dilated fundus examination was done as per ROP screening guidelines, and ROP was staged as per international classification for retinopathy of prematurity (ICROP) classification, 2021. HbF (%) was measured with high-performance liquid chromatography, and data was analyzed statistically. The relationship between HbF (%) and ROP was evaluated. Those infants who had ROP were further divided into treatment-requiring and non–treatment-requiring groups and HbF was compared in these groups at the first visit and after 1-month follow-up period. The outcome of ROP was studied with HbF levels. Results: A total of 410 preterm infants were included, out of which 110 infants had ROP (26.8%). Infants with ROP had significantly lower percentage of HbF with gestational age groups and birth weight groups, compared to infants without ROP. Higher percentage of HbF was associated with a lower prevalence of ROP. Higher concentration of HbF was found in the ROP infants who regressed spontaneously without treatment and less concentration was found in those who progressed to a severe disease and those who required treatment. The predictive ability of HbF (%) was 0.976 for ROP. Conclusion: Low fraction of HbF was found to be significantly associated with the development and progression of ROP.

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Section: Discussionmentioning

confidence: 99%

Role of fetal hemoglobin in the development and progression of retinopathy of prematurity in preterm infants

Prasad,

Dubey,

Kumar

et al. 2023

Indian Journal of Ophthalmology

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“…Anemia or low hemoglobin levels in early life of preterm infants have also been implicated as important risk factors for ROP development [8,35].…”

Section: Discussionmentioning

confidence: 99%

“…In our study, the total number of days of red blood cell transfusion is significantly associated with the development of ROP. Newborn's hemoglobin is predominantly fetal hemoglobin (HbF), with a higher affinity for oxygen than adult hemoglobin [8]. Transfusions are performed with adult blood containing almost 100% hemoglobin A (HbA), leading to a replacement of the physiological content of HbF by HbA, and a shift to the right in the oxygen-hemoglobin dissociation curve [46].…”

Section: Discussionmentioning

confidence: 99%

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Genetic Modulation of the Erythrocyte Phenotype Associated with Retinopathy of Prematurity—A Multicenter Portuguese Cohort Study

Fevereiro-Martins

Santos

Marques-Neves

et al. 2023

IJMS

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The development of retinopathy of prematurity (ROP) may be influenced by anemia or a low fetal/adult hemoglobin ratio. We aimed to analyze the association between DNA methyltransferase 3 β (DNMT3B) (rs2424913), Methylenetetrahydrofolate reductase (MTHFR) (rs1801133), and lysine-specific histone demethylase 1A (KDM1A) (rs7548692) polymorphisms, erythrocyte parameters during the first week of life, and ROP. In total, 396 infants (gestational age < 32 weeks or birth weight < 1500 g) were evaluated clinically and hematologically. Genotyping was performed using a MicroChip DNA on a platform employing iPlex MassARRAY®. Multivariate regression was performed after determining risk factors for ROP using univariate regression. In the group of infants who developed ROP red blood cell distribution width (RDW), erythroblasts, and mean corpuscular volume (MCV) were higher, while mean hemoglobin and mean corpuscular hemoglobin concentration (MCHC) were lower; higher RDW was associated with KDM1A (AA), MTHFR (CC and CC + TT), KDM1A (AA) + MTHFR (CC), and KDM1A (AA) + DNMT3B (allele C); KDM1A (AA) + MTHFR (CC) were associated with higher RDW, erythroblasts, MCV, and mean corpuscular hemoglobin (MCH); higher MCV and MCH were also associated with KDM1A (AA) + MTHFR (CC) + DNMT3B (allele C). We concluded that the polymorphisms studied may influence susceptibility to ROP by modulating erythropoiesis and gene expression of the fetal/adult hemoglobin ratio.

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“…45 Premature infants do not show effective protection against free iron because they have low levels of transferrin, and high levels of iron in adult hemoglobin, which can form free radicals that affect the developing retina. 46…”

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confidence: 99%

Latest Trends in Retinopathy of Prematurity: Research on Risk Factors, Diagnostic Methods and Therapies

Bezman¹,

Tiutiuca²,

Totolici³

et al. 2023

IJGM

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Retinopathy of prematurity (ROP) is a vasoproliferative disorder with an imminent risk of blindness, in cases where early diagnosis and treatment are not performed. The doctors' constant motivation to give these fragile beings a chance at life with optimal visual acuity has never stopped, since Terry first described this condition. Thus, throughout time, several specific advancements have been made in the management of ROP. Apart from the most known risk factors, this narrative review brings to light the latest research about new potential risk factors, such as: proteinuria, insulin-like growth factor 1 (IGF-1) and blood transfusions. Digital imaging has revolutionized the management of retinal pathologies, and it is more and more used in identifying and staging ROP, particularly in the disadvantaged regions by the means of telescreening. Moreover, optical coherence tomography (OCT) and automated diagnostic tools based on deep learning offer new perspectives on the ROP diagnosis. The new therapeutical trend based on the use of anti-VEGF agents is increasingly used in the treatment of ROP patients, and recent research sustains the theory according to which these agents do not interfere with the neurodevelopment of premature babies.

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Haemoglobin Levels in Early Life among Infants with and without Retinopathy of Prematurity

Cited by 8 publications

References 54 publications

Role of fetal hemoglobin in the development and progression of retinopathy of prematurity in preterm infants

Role of fetal hemoglobin in the development and progression of retinopathy of prematurity in preterm infants

Genetic Modulation of the Erythrocyte Phenotype Associated with Retinopathy of Prematurity—A Multicenter Portuguese Cohort Study

Latest Trends in Retinopathy of Prematurity: Research on Risk Factors, Diagnostic Methods and Therapies

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