Haemoglobin "Norfolk": A New Haemoglobin Found in an English Family

STUDIES OF THE INCORPORATION OF Fe59 INTO NORMAL AND ABNORMAL HEMOGLOBINS*

“…He was presumed to have hemoglobin J on the basis of electrophoretic mobility of hemoglobin specimens in acid and alkaline buffers (see Figure 1) (4), but no family studies could be carried out. Since this abnormal hemoglobin might also have been another electrophoretically rapid abnormal hemoglobin, e.g., hemoglobin N, rather than hemoglobin J, it is designated as "electrophoretically rapid hemoglobin component" or "J group hemoglobin" (5) in this study. The results of the studies of Fe59 incorporation in hemoglobin A and the rapid major component are recorded in Table IV.…”

Occurrence of Haemoglobin Norfolk (α₂ 57(E6) GIy→Asp β₂) at the Level of 33% in an Italian Family from Calabria

“…These amounts are significantly higher than both the 27% ob served in the English carrier [2] and the 25% reported in Japanese carriers [26] (un fortunately the level of Hb Norfolk in Nepa li Gurkhas has not so far been indicated). These findings would suggest that the same mutation has occurred in genotypes formed by either different number of a-chain loci or by loci having different expressions.…”

“…It was first described as a fast-moving haemoglobin in a young Englishman in Singapore by Ager et al [2], while the amino acid substitution was later identified by Baglioni [3]. Hb Nor folk has been successively reported, in asso ciation with /Mhalassaemia, in an Italian fa mily of Calabrian extraction living in Au stralia [33], and in Japanese subjects [26].…”

Genetic Polymorphism of the α-Globin Haplotypes in a Population from Calabria (Southern Italy)

“…Hemoglobin Norfolk, first discovered in 1958 by Ager et al [1958], was later found in a family of Calabrian extraction living in Australia [Wilkinson et al, 1967] and, re cently, in another Italian family from Cala bria [Marinucci et al, 1979].…”