Haemoglobinopathy Associated With Recurrent Stillbirth

Hydrops Fetalis in Taiwan

“…In four of the six such cases in this series, the mother had previous stillborn hydropic fetuses similar to the case reported by Banwell and Strickland. 2 Since this abnormality of hemoglobin is under genetic control, hydrops fetalis appears to recur in subsequent pregnancies.…”

“…6 Many cases of hydrops fetalis attributable to hemoglobin Bart's have been reported in countries of Southeast Asia, mainly in Chinese persons. 2 Twenty cases of hydrops fetalis were found, but two were dropped from this study because adequate clinical data were not obtained. Among the 18 cases studied, 14 were from National Taiwan University Hospital and four were from three of the other five hos-pitais.…”

Haemoglobin E and alpha-Thalassaemia.

“…Hb Bart's, in extremely variable amount, has been found in conditions ranging from the asymptomatic newborns (Tuchinda et al, 1959;Lie-Injo, 1959;Vella, 1959;Hendrickse et al, 1960;Fessas, 1960;Lie-Injo and Ti, 1961 ;Schneider and Haggard, 1961 ;Minnich et al, 1962 ;Silvestroni and Bianco, 1962 ;Weatherall, 1963) (Lie-Injo et al, 1962 ;Banwell and Strickland, 1965;Diamond et al, 1965 ;Wong, 1965 ;Pootrakul et al, 1967).…”

An Unusual Case of Hemoglobin Bart's Hydrops Fetalis

“…Many cases of nonimmunological hydrops fetalis associated with alpha-chain thalassemia have been described (Lie-Injo and Jo Bwan Hie 1960, Lie-Injo and Lie Hong Gie 1961, Lie-Injo 1962, Banwell and Strickland 1964, Diamond et al 1965, Pearson et al 1965, Kan et al 1967.…”