Haemolysis associated with diazoxide, used for the control of hypertension

Abstract

Summary Diazoxide, an agent used occasionally in the control of hypertension, has been associated with three haemolytic episodes in one patient. It is suggested that the mode of action is similar to that of diaminodiphenyl sulphone (dapsone) in acting as an oxidant stress to the ageing erythrocyte.

Heinz‐body anemia: “Bite Cell” variant— A light and electron microscopic study

“…The red cell changes in his illustrations are indistinguishable from those of the present investigation. The terms "contracted" and "fragmented" have survived and are still used in the literature to describe red cell changes in drug-induced oxidant hemolysis [28,34]. Even relatively current textbooks of hematology allude to signs of "red cell fragmentation" in describing severe episodes of drug-induced hemolytic anemia in patients with G6PD deficiency [37,38].…”