Haemolytic Activity of Suspensions of Different Silica Modifications and Inert Dusts

Stalder, Karlheinz; Stöber, Werner

doi:10.1038/207874a0

Cited by 121 publications

(54 citation statements)

References 6 publications

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“…Schnitzer and Pundsack (1970), using a red cell haemolysis test (Stalder and Stoeber, 1965) Available information on the cellular effect of mineral dusts indicates that platy talc is inactive, unlike the fibrous dusts silica and crocidolite which have significant biological activity. The data suggest that platy talc itself produces minimal cell toxicity, but that when contaminated with significant amounts of either silica or cytotoxic minerals such as chrysotile, the tissue response within the body is related to the cellular response to the cytotoxic minerals rather than to the particles of talc.…”

Section: Mineralogymentioning

confidence: 99%

The biology of talc.

Hildick‐Smith¹

1976

Occupational and Environmental Medicine

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-229. The biology of talc. Data are presented on the effects on health of talc dusts from exposure in industry and use of talc-containing health products. The mineralogy of talc and the composition of cosmetic and industrial grade talc dusts are described. Studies in animals are reviewed, and epidemiological data are considered in relation to exposures that occur during industrial and consumer uses of talc dusts. Hamsters exposed to 8 mg/m3 of respirable cosmetic grade talc dust for up to 150 minutes a day for 300 consecutive days showed no difference in incidence or nature of pathological lesions from those observed in a group of untreated animals. A retrospective study of the causes of death of 227 talc mine millers exposed to cosmetic grade talc at the threshold limit value for talc (20 million parts per cubic foot) for an average of 15 8 years showed that the causes of death were no different from those in a control cohort not exposed to talc dust. The available data indicate that talc dust exposure in the modern mining of cosmetic grade talc does not appear to be injurious to health. The significantly lower dust exposure in the normal use of cosmetic grade talc dusts in talc-containing health and cosmetic products confirms that their use is not a hazard to health.Increasing interest in the impact of environmental influences on health has in recent years focused attention on the significance of pollutants and prompted a reappraisal of environmental mineral dusts that have had extensive long-term use, but on which there is a paucity of correlated scientific data by which to

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Section: Mineralogymentioning

confidence: 99%

The biology of talc.

Hildick‐Smith¹

1976

Occupational and Environmental Medicine

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“…ese nanoparticles also can be labeled with Alexa Fluor 488 and conjugated to Claudin-4 antibody (CLN4), an antibody known to be speci�c to pancreatic cancer, and we describe the superior anticancer activity of doxorubicin-conjugated SiNPs conjugated to CLN4. [28][29][30]. In a typical experiment, 500 L of TEOS, 500 L of ammonium hydroxide, and 5 L of APTES were added to 5 mL of ethanol and stirred for 2 hours using a magnetic stirrer.…”

Section: Introductionmentioning

confidence: 99%

Amino-Functionalized Silica Nanoparticles: In Vitro Evaluation for Targeted Delivery and Therapy of Pancreatic Cancer

Kardys

Bharali

Mousa

2013

Journal of Nanotechnology

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We report a method of synthesis and optimization of amino-functionalized silica nanoparticles (SiNPs) and their in vitro evaluation as targeted delivery vehicles for the potential treatment of pancreatic cancer. SiNPs can efficiently encapsulate doxorubicin and can be attached to a targeting moiety such as anti-Claudin-4 (CLN4). e preferential uptake in pancreatic cancer cells, where CLN4 is overexpressed, of SiNPs when conjugated to CLN4 antibody (compared to nonconjugated SiNPs) was con�rmed by confocal microscopy. SiNPs encapsulating doxorubicin had greater efficacy in MTT assays than free doxorubicin, and when conjugated to CLN4, the efficacy was dramatically increased (at 1 M). No apparent carrier toxicity was observed when void SiNPs were used. SiNPs carrying a chemotherapeutic drug have the potential to be used as a targeted therapy for lethal cancers, such as pancreatic cancer. Also, incorporation of �uorescent probes in these SiNPs creates the possibility of their use as an imaging probe for diagnostic purposes.

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“…morphology, charge, porosity) as well as material composition. [24][25][26] In our studies, hemolysis assays were used to explore the differential biocompatibility of CdTe-TGA and CdTe/CdS-DHLA QDs with red blood cells of rabbits.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Highly Stable CdTe/CdS Quantum Dots with Biocompatibility

et al. 2010

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Thioglycolic acid (TGA) is a popular coating material for the preparation of aqueous quantum dots (QDs), yet dihydrolipoic acid (DHLA) has not been studied much. Here we present a detailed study on the aqueous synthesis of CdTe/CdS quantum dots with a DHLA coating. The outer CdS shell and DHLA stabilizer provide efficient confinement of electron and hole wave functions inside the nanocrystal as well as high photochemical stability. At the optimum ratios and reaction conditions, the results indicate that the DHLA-capped CdTe/CdS QDs exhibit high fluorescence quantum yields (QYs) of about 48 % over a spectral range of 551-571 nm, and the best QY is 87 %. These DHLA-capped core-shell QDs are

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Haemolytic Activity of Suspensions of Different Silica Modifications and Inert Dusts

Cited by 121 publications

References 6 publications

The biology of talc.

The biology of talc.

Amino-Functionalized Silica Nanoparticles: In Vitro Evaluation for Targeted Delivery and Therapy of Pancreatic Cancer

Synthesis of Highly Stable CdTe/CdS Quantum Dots with Biocompatibility

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