Haemolytic Uraemic Syndrome

Neild, Gh

doi:10.1159/000186551

Cited by 15 publications

(3 citation statements)

References 7 publications

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“…HUS may be associated with a variety of conditions such as pregnancy, the postpartum period and the administration of oral contraceptives, cytotoxic drugs and cyclosporine A (CyA) [6]. HUS may be associated with a variety of conditions such as pregnancy, the postpartum period and the administration of oral contraceptives, cytotoxic drugs and cyclosporine A (CyA) [6].…”

mentioning

confidence: 99%

Recurrent haemolytic uraemic syndrome in a boy with focal and segmental glomerulosclerosis

et al. 1992

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mentioning

confidence: 99%

Recurrent haemolytic uraemic syndrome in a boy with focal and segmental glomerulosclerosis

et al. 1992

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“…3 Os achados laboratoriais mostram uma anemia hemolítica microangiopática, possivelmente causada por fatores oxidantes liberado pelo agente etiológico, sendo bem documentada em casos de infecções por pneumococo. 5 A contagem de reticulócitos e LDH é elevada assim como bilirrubinas fração indireta caracterizando hemólise. A trombocitopenia geralmente é menos intensa e acredita-se que deva ser motivada pela ativação e consumo de plaquetas no leito endotelial.…”

Section: Discussionunclassified

Síndrome hemolítico-urêmica esporádica pós-parto

Moreira

Gil²,

Juliani³

et al. 2008

Rev. Bras. Hematol. Hemoter.

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“…The pathogenesis of HUS is characterized by endothelial cell damage of glomeruli and/or arterioles of the kidney (2). In severe cases of HUS, endothelial cell damage is not limited to the kidney but extends to other organs, such as the brain and pancreas (3). The epidemic form of HUS is strongly associated with verocytotoxin (VT)-producing Escherichia coli infection (4).…”

mentioning

confidence: 99%

Verocytotoxin-Induced Apoptosis of Human Microvascular Endothelial Cells

Pijpers¹,

Setten²,

Heuvel³

et al. 2001

Journal of the American Society of Nephrology

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Abstract. The pathogenesis of the epidemic form of hemolytic uremic syndrome is characterized by endothelial cell damage. In this study, the role of apoptosis in verocytotoxin (VT)-mediated endothelial cell death in human glomerular microvascular endothelial cells (GMVEC), human umbilical vein endothelial cells, and foreskin microvascular endothelial cells (FMVEC) was investigated. VT induced apoptosis in GMVEC and human umbilical vein endothelial cells when the cells were prestimulated with the inflammatory mediator tumor necrosis factor-α (TNF-α). FMVEC displayed strong binding of VT and high susceptibility to VT under basal conditions, which made them suitable for the study of VT-induced apoptosis without TNF-α interference. On the basis of functional (flow cytometry and immunofluorescence microscopy using FITC-conjugated annexin V and propidium iodide), morphologic (transmission electron microscopy), and molecular (agarose gel electrophoresis of cellular DNA fragments) criteria, it was documented that VT induced programmed cell death in microvascular endothelial cells in a dose- and time-dependent manner. Furthermore, whereas partial inhibition of protein synthesis by VT was associated with a considerable number of apoptotic cells, comparable inhibition of protein synthesis by cycloheximide was not. This suggests that additional pathways, independent of protein synthesis inhibition, may be involved in VT-mediated apoptosis in microvascular endothelial cells. Specific inhibition of caspases by Ac-Asp-Glu-Val-Asp-CHO, but not by Ac-Tyr-Val-Ala-Asp-CHO, was accompanied by inhibition of VT-induced apoptosis in FMVEC and TNF-α-treated GMVEC. These data indicate that VT can induce apoptosis in human microvascular endothelial cells.

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Haemolytic Uraemic Syndrome

Cited by 15 publications

References 7 publications

Recurrent haemolytic uraemic syndrome in a boy with focal and segmental glomerulosclerosis

Recurrent haemolytic uraemic syndrome in a boy with focal and segmental glomerulosclerosis

Síndrome hemolítico-urêmica esporádica pós-parto

Verocytotoxin-Induced Apoptosis of Human Microvascular Endothelial Cells

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