Haemophilia A and B as a cause for secondary osteoporosis and increased fracture risk

Anagnostis, Panagiotis; Karras, Spyridon Ν.; Paschou, Stavroula Α.; Goulis, Dimitrios G.

doi:10.1097/mbc.0000000000000330

Cited by 16 publications

(19 citation statements)

References 36 publications

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“…This secondary osteoporosis may be induced by glucocorticoids (steroid‐induced osteoporosis), thiazide diuretics, opioids, antiviral therapies, and numerous other drugs routinely used in management of nonskeletal conditions . Conditions such as hemophilia and prolonged bed rest can also result in secondary osteoporosis. We have reviewed the changes in bone quality caused by these drugs elsewhere; here we present two examples, the most common form of secondary osteoporosis, that induced by steroids and that associated with treatment for chronic obstructive pulmonary disease (COPD).…”

Section: Bone Quality Changes In Diseasementioning

confidence: 99%

Bone quality changes associated with aging and disease: a review

Boskey

Imbert

2017

Annals of the New York Academy of Sciences

118

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Bone quality encompasses all the characteristics of bone that, in addition to density, contribute to its resistance to fracture. In this review, we consider changes in architecture, porosity and composition, including collagen structure, mineral composition and crystal size. These factors all are known to vary with tissue and animal ages, and health status. Bone morphology and presence of micro-cracks which also contribute to bone quality, will not be discussed in this review. Correlations with mechanical performance for collagen cross-linking, crystallinity and carbonate content are contrasted with mineral content. Age dependent changes in humans and rodents are discussed in terms of using rodent models of disease. Examples are osteoporosis, osteomalacia, osteogenesis imperfecta, and osteopetrosis, in both humans and animal models. Each of these conditions, along with aging, are associated with increased fracture risk for distinct reasons.

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Section: Bone Quality Changes In Diseasementioning

confidence: 99%

Bone quality changes associated with aging and disease: a review

Boskey

Imbert

2017

Annals of the New York Academy of Sciences

118

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“…This confirmed by further surveys on individuals with hemophilia. [ 3 39 40 41 42 43 44 ] After that reduced bone density has been shown in two other bleeding disorders (hemophilia B and combined factor V and VIII deficiency). [ 3 44 45 ] There are gaps in status of bone density in vWD, factor VII deficiency, factor V deficiency, factor X deficiency, factor XIII deficiency, fibrinogen abnormalities, and platelet disorders.…”

Section: The New Horizon For Further Surveysmentioning

confidence: 99%

“…[ 3 39 40 41 42 43 44 ] After that reduced bone density has been shown in two other bleeding disorders (hemophilia B and combined factor V and VIII deficiency). [ 3 44 45 ] There are gaps in status of bone density in vWD, factor VII deficiency, factor V deficiency, factor X deficiency, factor XIII deficiency, fibrinogen abnormalities, and platelet disorders. Also, our finding and understanding about the prevalence of osteopenia and osteoporosis in various types of bleeding disorders (severe, moderate, and mild), effective risk factors, pathogenesis of reduced bone density, influences of various treatments of osteopenia and osteoporosis in bleeding patients and possible influence of physical therapy and sports are limited and need to be investigated.…”

Section: The New Horizon For Further Surveysmentioning

confidence: 99%

Bone Density Status in Bleeding Disorders: Where Are We and What Needs to Be Done?

Mansouritorghabeh

Rezaieyazdi

2017

J Bone Metab

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Bleeding disorders, including hemophilia, can be seen in every ethnic population in the world. Among various bleeding disorders, reduced bone density has been addressed in hemophilia A. In recent years, there has been an increasing interest in addressing osteopenia and osteoporosis in hemophilia A. There is little or no study about the possible susceptibility of other individuals with bleeding disorders to reduced bone density. Questions have been raised about the role of blood coagulation factors in bone mineralization. This review provides new insight and ideas for further survey in the field of bleeding disorders and reduced bone density.

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“…Vitamin D deficiency and low levels of clotting factor [9] may, also, play a role. Each factor can lead to low BMD through a different pathway and to a variable degree [10].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D deficiency and osteoporosis in hemophilic children

Eldash

Atwa²,

Saad³

2017

Blood Coagulation &Amp; Fibrinolysis

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The aim of this study is to investigate bone state and factors affecting it in children with hemophilia. This is a case-control study that included 37 children with hemophilia and 37 healthy controls. The patients were selected from the outpatient pediatric hematology clinic of Fayoum University Hospital, Egypt. Bone mineral density, serum vitamin D, parathormone, calcium, phosphorus, and calcium creatinine ratio levels were evaluated. Vitamin D level and bone mineral density were significantly lower in hemophiliacs than in control group (P < 0.0001). About 43.2% of cases had moderate vitamin D deficiency, whereas 35.1% had mild deficiency. Vitamin D positively correlated with bone mineral density Z-score, whereas it negatively correlated with total joint score. Positive correlation between bone mineral density and age was also found. Serum levels of urea, urinary calcium creatinine ratio, and parathormone were found to be higher in cases than in control. Also, serum calcium level was found to be lower in patients than in controls. We concluded that vitamin D deficiency is an essential cause of decreased bone mineral density in hemophilic children. Hemophilic arthropathy with consecutive immobilization plays an important role in vitamin D deficiency and decreased bone mineral density.

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Haemophilia A and B as a cause for secondary osteoporosis and increased fracture risk

Cited by 16 publications

References 36 publications

Bone quality changes associated with aging and disease: a review

Bone quality changes associated with aging and disease: a review

Bone Density Status in Bleeding Disorders: Where Are We and What Needs to Be Done?

Vitamin D deficiency and osteoporosis in hemophilic children

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