Haemophilus influenzae Meningitis in Adults

Eykyn, Susannah J.; Thomas, R.D.; Phillips, Ian

doi:10.1136/bmj.2.5917.463

Cited by 40 publications

(5 citation statements)

References 9 publications

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“…Infections caused by H. influenzae are extremely uncommon in older children and adults, only four cases being diagnosed in Birmingham during the period often years. When these do occur they frequently complicate serious underlying disease (Eykyn, Thomas & Phillips, 1974). The above approach has been advocated by Lambert (1979).…”

Section: Laboratory Resultsmentioning

confidence: 99%

Bacterial meningitis – ten years experience

Davey¹,

Cruikshank²,

McManus

et al. 1982

J. Hyg.

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SummaryBetween January 1968 and December 1977, 635 cases of acute bacterial meningitis were admitted to hospitals in the Birmingham Area Health Authority. The epidemiology of these cases was analysed and compared with the 270 cases which were admitted to the regional infectious diseases unit at East Birmingham Hospital (E.B.H.). In children and young adults the meningococcus was the commonest causative organism while over the age of 25 pneumococcal meningitis predominated. AlthoughHaemophilus influenzaewas the second commonest infecting organism it was a rare cause of meningitis in school children and adults, only four cases presenting in these age groups in the Birmingham Area.A detailed analysis was made of the symptoms, signs, laboratory investigations and clinical course of the 270 cases treated at E.B.H.The mortality in the patients with pneumococcal meningitis was 30%. In the meningococcal group it was 3·5% and in the haemophilus groups 7·7%.An analysis of the various treatment regimes employed in the 270 E.B.H. patients supports the view that a single antibiotic is sufficient for the therapy of most forms of bacterial meningitis. Intrathecal antibiotic administration is unnecessary in pyogenic meningitis caused by meningococci, pneumococci orH. influenzae.

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Section: Laboratory Resultsmentioning

confidence: 99%

Bacterial meningitis – ten years experience

Davey¹,

Cruikshank²,

McManus

et al. 1982

J. Hyg.

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“…Reasons for operation include trauma (11 cases), idiopathic thrombocytopenic purpura (5 cases), and hereditary spherocytosis (5 cases) ( Table 1). 8 [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] The deaths occurred suddenly in patients in early middle age; the mean age at infection was 37 years. None had been given any prophylactic treatment; indeed, the risk of infection in adults was not recognised until the late sixties, and in most cases the operation had been performed earlier.…”

Section: Discussionmentioning

confidence: 99%

Postsplenectomy sepsis 10 years or more after operation.

Evans¹

1985

J Clin Pathol

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SUMMARY Three new cases (two fatal) of postsplenectomy sepsis occurring 14, 25, and 26 years after operation for hereditary spherocytosis are described. There are now 25 cases in the published work in which this complication occurred 10 or more years after operation, 14 of which were fatal. The mean age of onset is 37 years. The features of the disease are similar to those seen in other postsplenectomy infections, and pneumococcal infection was responsible in 19 cases (76%). The major predisposing illnesses were trauma, hereditary spherocytosis, and idiopathic thrombocytopenia.

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“…Splenectomized patients are at risk of developing fulminant sepsis greater than 500‐fold compared with subjects with an intact spleen 1 . These patients are unusually vulnerable to bacterial and protozoal infections 2–5 . Complications similar to those occurring with splenectomy may occur in patients with an intact spleen if there is associated impaired splenic function.…”

Section: Introductionmentioning

confidence: 99%