2021
DOI: 10.1007/s10096-021-04247-w
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Haemophilus influenzae one day in Denmark: prevalence, circulating clones, and dismal resistance to aminopenicillins

Abstract: PurposeHaemophilus in uenzae is a common cause of mucosal infections that warrants accurate surveillance.We aimed to assess the prevalence of the species in clinical specimens, and characterise population structure and resistance to aminopenicillins by whole genome sequencing. MethodsWe assessed the point prevalence by entering the database records of one day in Denmark, and examined the genome sequences of nationwide, collected isolates from the same day. ResultsThe prevalence of H. in uenzae in clinical samp… Show more

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Cited by 7 publications
(8 citation statements)
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“…The study strain sequences were compared with type strains of H. influenzae, Haemophilus aegyptius, Haemophilus haemolyticus, and Haemophilus seminalis, with five reference unencapsulated isolates [18], and with selected fastANI reference sequences of putative new species from the Genome Taxonomy Database (GDTB) [13,14] (Figure 1). The predominance of phylogenetic group I and the uniform distribution of isolates within the group mimic a recent, nation-wide characterisation of H. influenzae cultured from various specimens on a single day in Denmark, where all 62 isolates belonged to phylogenetic group I [20]. Freeform shapes in Figure 1 depict the borders of the putative species "Haemophilus influenzae E" and "Haemophilus influenzae F", as defined by pairwise Average Nucleotide Identity (ANI).…”
Section: Genomic Characterisation Of Causative Agentsmentioning
confidence: 79%
“…The study strain sequences were compared with type strains of H. influenzae, Haemophilus aegyptius, Haemophilus haemolyticus, and Haemophilus seminalis, with five reference unencapsulated isolates [18], and with selected fastANI reference sequences of putative new species from the Genome Taxonomy Database (GDTB) [13,14] (Figure 1). The predominance of phylogenetic group I and the uniform distribution of isolates within the group mimic a recent, nation-wide characterisation of H. influenzae cultured from various specimens on a single day in Denmark, where all 62 isolates belonged to phylogenetic group I [20]. Freeform shapes in Figure 1 depict the borders of the putative species "Haemophilus influenzae E" and "Haemophilus influenzae F", as defined by pairwise Average Nucleotide Identity (ANI).…”
Section: Genomic Characterisation Of Causative Agentsmentioning
confidence: 79%
“…The detection rate of drug resistance gene TEM-1 was the highest, indicating that the drug resistance phenotype BLPAR mediated by TEM-1 β-lactamase-producing strains was the primary drug resistance mechanism in H. influenzae ( Fu et al 2021 ). Mutations in the ftsI gene ( PBP3S and PBP3BLN ) result in the BLNAR phenotype ( Nørskov-Lauritsen et al 2021 ). The β-lactamase production and ftsI gene mutations work together to result in BLPACR, which is consistent with the resistance mechanism reported in the literature ( Schotte et al 2019 ).…”
Section: Discussionmentioning
confidence: 99%
“…The introduction of the Hib vaccine in the 1990s led to a significant reduction in Hib-caused infections worldwide. However, this reduction was followed by serotype replacement, primarily affecting age groups other than children (Watt et al, 2009;Jalalvand and Riesbeck, 2018;McElligott et al, 2020;Nørskov-Lauritsen et al, 2021;Tønnessen et al, 2022). A previous study in Denmark, which included data from 2000 to 2008, reported an incidence rate of around 1.5 per 100,000 population for the Danish population (Laupland et al, 2011).…”
Section: Discussionmentioning
confidence: 99%
“…A previous study in Denmark, which included data from 2000 to 2008, reported an incidence rate of around 1.5 per 100,000 population for the Danish population (Laupland et al, 2011). Another Danish study estimated the prevalence of H. influenzae in clinical samples on January 10th, 2018, to be around 1.78 per 100,000 person-days (all samples) (Nørskov-Lauritsen et al, 2021). In this study, a similar median incidence rate of 2.0 per 100,000 was observed (Figure 1).…”
Section: Discussionmentioning
confidence: 99%