Haemophilus influenzae periorbital cellulitis in a 95-year-old patient

Veraldi, Stefano; Benzecry, Valentina

doi:10.36150/2499-6564-n489

Cited by 1 publication

(1 citation statement)

References 14 publications

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“…The bacterium may benefit from the capsule's capacity for survival by being protected during transmission and colonization as well as being resistant to complementmediated death and phagocytosis [21]. H. influenzae causes many types of diseases and infections such as Otitis media [22], Bronchitis [23], Cellulitis [24], pneumonia [25], and bloodstream infection [26]. The protein 3ZH5 used in this study is a multifunctional adhesion that is involved in direct interactions with lung epithelial cells hence the diseases which affect the lungs are Bronchitis and Pneumonia.…”

Section: Discussionmentioning

confidence: 99%

Computational Analysis of Phytocompounds Present in Murraya Koenigii to Target Haemophilus Influenzae Disease

GANESH¹

2022

Innovare J Med Sci

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Objective: Haemophilus influenzae is a key contributor to meningitis, pneumonia, and sepsis-related illnesses and fatalities in children around the world during the pre-vaccine era (the early 1990s) and still continues to infect many individuals across the globe. This research examines various bioactive substances from plant sources for the prediction of the efficacy of the plant-based ligands to combat H. influenzae. Methods: The present study implemented computational methods to assess the effectiveness of several phytochemicals toward the H. influenzae protein. The virtual screening tool PyRx was used to systematically perform molecular docking. To test the binding affinity with the H. influenzae protein 3ZH5, 10 phytocompounds were selected from Murraya koenigii based on the previous literature. Using ADMET filters, the pharmacological evaluation of the ligands was performed. Results: The plant M. koenigii’s phytocompounds Mahanimbine, Murrayacinine, and Murrayazolinine were found to be the most effective antagonists for the protein 3ZH5, according to the docking data. Conclusion: Due to their high affinity for the protein, all of these bioactive substances could be considered as deserving candidates for the suppression of H. influenzae.

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Section: Discussionmentioning

confidence: 99%

Computational Analysis of Phytocompounds Present in Murraya Koenigii to Target Haemophilus Influenzae Disease

GANESH¹

2022

Innovare J Med Sci

View full text Add to dashboard Cite

show abstract

Haemophilus influenzae periorbital cellulitis in a 95-year-old patient

Cited by 1 publication

References 14 publications

Computational Analysis of Phytocompounds Present in Murraya Koenigii to Target Haemophilus Influenzae Disease

Computational Analysis of Phytocompounds Present in Murraya Koenigii to Target Haemophilus Influenzae Disease

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