2011
DOI: 10.1128/jcm.02200-10
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Haemophilus influenzae Type b Carriage and Novel Bacterial Population Structure among Children in Urban Kathmandu, Nepal

Abstract: Haemophilus influenzae type b (Hib) is a major cause of invasive bacterial infection in children that can be prevented by a vaccine, but there is still uncertainty about its relative importance in Asia. This study investigated the age-specific prevalence of Hib carriage and its molecular epidemiology in carriage and disease in Nepal. Oropharyngeal swabs were collected from children in Kathmandu, Nepal, from 3 different settings: a hospital outpatient department (OPD), schools, and children's homes. Hib was iso… Show more

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Cited by 15 publications
(27 citation statements)
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“…Three focused on carriage of Hib [72][74]. The prevalence of Hib carriage was approximately 5% in these studies, with the highest prevalence (10.9%) in rural children [72][74].…”
Section: Resultsmentioning
confidence: 99%
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“…Three focused on carriage of Hib [72][74]. The prevalence of Hib carriage was approximately 5% in these studies, with the highest prevalence (10.9%) in rural children [72][74].…”
Section: Resultsmentioning
confidence: 99%
“…Three focused on carriage of Hib [72][74]. The prevalence of Hib carriage was approximately 5% in these studies, with the highest prevalence (10.9%) in rural children [72][74]. The percentage of H. influenzae isolates that belonged to serotype b was 0.7%–69% in healthy children [43], [55], [73][76], 0.9%–18% in sick children [61], [62], [77], and 49% in immunocompromised children [70].…”
Section: Resultsmentioning
confidence: 99%
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“…Children are significant reservoirs of Hib, with carriage rates ranging from 4.2% to 9% in the school-aged population (1,2). Vaccination with the Hib vaccine significantly reduces Hib carriage in the pediatric population (3).…”
mentioning
confidence: 99%