Haemophilus pittmaniae and Leptotrichia spp. Constitute a Multi-Marker Signature in a Cohort of Human Papillomavirus-Positive Head and Neck Cancer Patients

Mougeot, Jean-Luc; Beckman, Micaela F.; Langdon, Holden C; Lalla, Rajesh V.; Brennan, Michael T.; Mougeot, Farah K. Bahrani

doi:10.3389/fmicb.2021.794546

Cited by 8 publications

(6 citation statements)

References 61 publications

(87 reference statements)

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“…The reason that these common vaginal bacterial species are found in the oral cavity is not clear, but transfer to the oral microbiota by sexual behavior is one possibility. Recent reports have documented changes in the diversity of the oral microbiota of HPV-infected individuals [ 191 ] and changes in the overall microbial community and bacterial abundance among HPV-positive OPC patients [ 192 , 193 ]. There have also been reports on the involvement of Candida albicans in carcinogenesis [ 194 ].…”

Section: Hpvmentioning

confidence: 99%

Role of Microbiota in Viral Infections and Pathological Progression

Mizutani

Ishizaka

Koga

et al. 2022

Viruses

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Viral infections are influenced by various microorganisms in the environment surrounding the target tissue, and the correlation between the type and balance of commensal microbiota is the key to establishment of the infection and pathogenicity. Some commensal microorganisms are known to resist or promote viral infection, while others are involved in pathogenicity. It is also becoming evident that the profile of the commensal microbiota under normal conditions influences the progression of viral diseases. Thus, to understand the pathogenesis underlying viral infections, it is important to elucidate the interactions among viruses, target tissues, and the surrounding environment, including the commensal microbiota, which should have different relationships with each virus. In this review, we outline the role of microorganisms in viral infections. Particularly, we focus on gaining an in-depth understanding of the correlations among viral infections, target tissues, and the surrounding environment, including the commensal microbiota and the gut virome, and discussing the impact of changes in the microbiota (dysbiosis) on the pathological progression of viral infections.

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Section: Hpvmentioning

confidence: 99%

Role of Microbiota in Viral Infections and Pathological Progression

Mizutani

Ishizaka

Koga

et al. 2022

Viruses

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“…Another elevated genus found in Toombak users in this study was Leptotrichia , associated with more severe levels of oral epithelial dysplasia 43 including in those who developed pancreatic cancer 44 . Leptotrichia abundance in the oral cavity has been implicated in head and neck cancer 45 and it was significantly increased in a cohort of heavy smokers in one study from the United Arab Emirates 46 .…”

Section: Resultsmentioning

confidence: 99%

Altered oral microbiome in Sudanese Toombak smokeless tobacco users carries a newly emerging risk of squamous cell carcinoma development and progression

Sami

Elimairi

Ryan

et al. 2023

Sci Rep

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There are an estimated 6–10 million smokeless tobacco (Toombak) users in Sudan, the majority being males. Toombak is known to be a carcinogenic product that is likely to modify the oral microbiome spatiality into a high-risk potential for the development and progression of oral cancer, but previous studies are lacking in this field. Here, we endeavour for the first time the exploration of the oral microbiome in key mucosal areas of the oral cavity and assess the microbiome variations in premalignant and oral squamous cell carcinoma (OSCC) samples from both users and non-users of Toombak. 16S rRNA sequencing was performed on DNA obtained from pooled saliva, oral mucosa and supragingival plaque from 78 Sudanese users and non-users of Toombak, aged between 20 and 70 years. In 32 of the pooled saliva samples, the mycobiome (fungal) environment was analysed through ITS sequencing. Then, 46 formalin-fixed paraffin-embedded samples of premalignant and OSCC samples were collected, and their associated microbiomes sequenced. The oral Sudanese microbiome was found to be enriched in Streptococcaceae, but Staphylococcaceae were significantly more abundant amongst Toombak users. Genera enriched in the oral cavity of Toombak users included Corynebacterium_1 and Cardiobacterium while in non-users, Prevotella, Lactobacillus and Bifidobacterium were prominent. Aspergillus was the most abundant fungus in the mouths of Toombak users with a marked loss of Candida. The genus Corynebacterium_1 was abundant in the buccal, floor of the mouth and saliva microbiomes as well as in oral cancer samples from Toombak users indicating a possible role for this genus in the early stages of oral cancer development. An oral cancer microbiome that favours poor survival and metastasis in those who use Toombak also emerged that includes the genera Stenotrophomonas and Schlegelella. Those utilising Toombak carry an altered oral microbiome that may be an additional risk factor for this products carcinogenicity to the oral structures. These significant microbiome modulations are a newly emerging key driving factor in oral cancer development and progression in Toombak users while it is also shown that Toombak users carry an oral cancer microbiome that may increase the potential for a poorer prognosis.

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“…In retrospective cases of colon cancer, we found evidence of an increase in an ASV classified as Fusobacterium peridonticum by two different microbiome DA frameworks (corncob, ANCOM-II). This species a member of the core oral microbiome genus Fusobacterium has previously been identified as being increased in relative abundance in the oral microbiome of oral small cell carcinoma 40 , head and neck cancer 41 , and pancreatic cancer patients 42 . Whether this oral microbe represents a specific connection to colon cancer, cancer development, or other events associated with cancer diagnosis such as treatment or lifestyle changes is yet to be investigated.…”

Section: Discussionmentioning

confidence: 96%

Investigating the oral microbiome in retrospective and prospective cases of prostate, colon, and breast cancer

Nearing

DeClercq

Langille

2023

npj Biofilms Microbiomes

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The human microbiome has been proposed as a potentially useful biomarker for several cancers. To examine this, we made use of salivary samples from the Atlantic Partnership for Tomorrow’s Health (PATH) project and Alberta’s Tomorrow Project (ATP). Sample selection was divided into both a retrospective and prospective case control design examining prostate, breast, and colon cancer. In total 89 retrospective and 260 prospective cancer cases were matched to non-cancer controls and saliva samples were sequenced using 16S rRNA gene sequencing. We found no significant differences in alpha diversity. All beta diversity measures were insignificant except for unweighted UniFrac profiles in retrospective breast cancer cases and weighted UniFrac, Bray-Curtis and Robust Atchinson’s distances in colon cancer after testing with age and sex adjusted MiRKAT models. Differential abundance (DA) analysis showed several taxa that were associated with previous cancer in all three groupings. Only one genus (Clostridia UCG-014) in breast cancer and one ASV (Fusobacterium periodonticum) in colon cancer was identified by more than one DA tool. In prospective cases three ASVs were associated with colon cancer, one ASV with breast cancer, and one ASV with prostate cancer. Random Forest classification showed low levels of signal in both study designs in breast and prostate cancer. Contrastingly, colon cancer did show signal in our retrospective analysis (AUC: 0.737) and in one of two prospective cohorts (AUC: 0.717). Our results indicate that it is unlikely that reliable microbial oral biomarkers for breast and prostate cancer exist.. However, further research into the oral microbiome and colon cancer could be fruitful.

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Haemophilus pittmaniae and Leptotrichia spp. Constitute a Multi-Marker Signature in a Cohort of Human Papillomavirus-Positive Head and Neck Cancer Patients

Cited by 8 publications

References 61 publications

Role of Microbiota in Viral Infections and Pathological Progression

Role of Microbiota in Viral Infections and Pathological Progression

Altered oral microbiome in Sudanese Toombak smokeless tobacco users carries a newly emerging risk of squamous cell carcinoma development and progression

Investigating the oral microbiome in retrospective and prospective cases of prostate, colon, and breast cancer

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