Hæmorheological studies on the plasmatic zone in the microcirculation of the cheek pouch of Chinese and Syrian hamsters1

Copley, Alfred L.; Staple, P. H.

doi:10.3233/bir-1962-1102

Cited by 45 publications

(6 citation statements)

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“…It seems unlikely on more general rheological grounds discussed by Starkey (37,65,66). Our in vivo measurements support Taylor's extra vivum studies (37,64).…”

Section: Axial Stream Of Erythrocytes In Glass Tubes and Blood Vesselssupporting

confidence: 80%

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The Robin Fåhræus Memorial Lecture1

Copley¹

1989

BIR

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“…It seems unlikely on more general rheological grounds discussed by Starkey (37,65,66). Our in vivo measurements support Taylor's extra vivum studies (37,64).…”

Section: Axial Stream Of Erythrocytes In Glass Tubes and Blood Vesselssupporting

confidence: 80%

“…In 1839 Poiseuille proposed that the plasmatic zone in the circulation of the blood in vivo consists of two portions, viz., a wide mobile portion and, in close proximity to the vessel wall, a very narrow immobile portion (37).…”

Section: Some Basic Experimental Studies Antedating Those By Fahraausmentioning

confidence: 99%

The Robin Fåhræus Memorial Lecture1

Copley¹

1989

BIR

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“…1) in which the endothelial surface is covered by a thin molecular layer and an immobile sheet of plasma. The existence of the latter was inferred from intravital microscopic experiments in the hamster cheek pouch [23]. After intravenous injection of a dye (pontamine sky blue) an unstained plasmatic zone adjacent to the endothelial surface was observed.…”

Section: Introductionmentioning

confidence: 99%

The endothelial surface layer

Pries

Secomb

Gaehtgens

2000

Pflugers Arch - Eur J Physiol

772

695

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The endothelial lining of blood vessels presents a large surface area for exchange of materials between blood and tissues, and is critically involved in many other processes such as regulation of blood flow, inflammatory responses and blood coagulation. It has long been known that the luminal surface of the endothelium is lined with a glycocalyx, a layer of membrane-bound macromolecules which has been determined by electron microscopy to be several tens of nanometers thick. However, investigations in vivo have indicated the presence of a much thicker endothelial surface layer (ESL), with an estimated thickness ranging from 0.5 microm to over 1 microm, that restricts the flow of plasma and can exclude red blood cells and some macromolecular solutes. The evidence for the existence of the ESL, hypotheses about its composition and biophysical properties, its relevance to physiological processes, and its possible clinical implications are considered in this review.

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“…The idea that the thickness of the peripheral plasma layer depended upon the flow rate as well as the relative size of the erythrocyte to the vessel has also been put forward by Krogh [1]. Subsequently, Copley and his associates [2][3][4] measured the peripheral plasma layer in the microvessels of a hamster's cheek pouch by using microphotographic techniques and confirmed the findings of Poiseuille. Basing upon the experimental investigations carried out by Block et al [5,6], it has been shown that the ratio of the peripheral plasma layer to the diameter of the arteriole increased as the vessel diameter decreased, while a wide variation in flow rate did not cause significant alteration in the size of the layer.…”

Section: Introductionmentioning

confidence: 71%

Pulsatile blood flow through arterioles

Chakravarty

1987

Rheol Acta

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An analytical study was made to examine the effect of vascular deformability on the pulsatile blood flow in arterioles through the use of a suitable mathematical model. The blood in arterioles is assumed to consist of two layersboth Newtonian but with differing coefficients of viscosity. The flow characteristics of blood as well as the resistance to flow have been determined using the numerical computations of the resulting expressions. The applicability of the model is illustrated using numerical results based on the existing experimental data.

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Hæmorheological studies on the plasmatic zone in the microcirculation of the cheek pouch of Chinese and Syrian hamsters1

Cited by 45 publications

References 0 publications

The Robin Fåhræus Memorial Lecture1

The Robin Fåhræus Memorial Lecture1

The endothelial surface layer

Pulsatile blood flow through arterioles

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