Haemorrhagic cystitis associated with adenovirus in a patient with AIDS treated for a non-Hodgkin's lymphoma

Abstract

Adenovirus-induced haemorrhagic cystitis has been reported chiefly in bone marrow or kidney transplant recipients. We report here on an HIV-positive patient treated for a Burkitt's lymphoma who developed gross haematuria associated with fever and burning urination. Usual causes of haematuria were ruled out: lithiasis, urinary tract lesions, glomerulonephritis, mycobacterium and schistosoma infections, and drug toxicity. Adenovirus was detected by cellular cultures and BK/JC virus DNA sequences were detected using a polymerase chain reaction method. Because BK/JC virus shedding is very common (75%) in HIV patients receiving chemotherapy, our data strongly suggest that adenovirus was responsible for the haemorrhagic cystitis in our patient. In conclusion, adenovirus should be considered as a potential cause of haemorrhagic cystitis in AIDS patients whose immunosuppression is aggravated by cytotoxic drugs.

Prevalence of adenovirus respiratory tract and hiv co-infections in patients attending the University of Ilorin, teaching hospital, Ilorin, Nigeria

“…It has been reported elsewhere that the demonstration of massive, rapid and largely irreversible HIV-mediated destruction of memory CD4+ T Cells predominantly occurring in the gut is suggestive that primary HIV infection maybe the only time that intervention could confer lasting immunological benefit [ 28 ] However, there was significant difference between the ART status of HIV patients and Adenovirus co-infections (p < 0.05). This supports the work done by Ghez et al ., in 2000, where after 2 weeks of previous cycle of administering chemotherapy to an HIV patient for Burkitt lymphoma, Adenovirus-associated hemorrhagic cystitis was reported in the patient [ 29 ]. Nevertheless, vaccination still staggeringly stands out as a major way of preventing Adenovirus co-infections in human populations, especially in imunocompromised patients such as the HIV/AIDS patients.…”