Haemorrhagic pneumonia caused by Stenotrophomonas maltophilia in two newborns

Abstract

Invasive procedures and antibiotic treatment increase the risk of nosocomial infections in neonatal intensive care units. Early identification and appropriate treatment is important. Herein we report two cases of massive hemorrhagic pneumonia caused by Stenotrophomonas maltophilia. The first case was diagnosed with congenital pneumonia; a chest tube was inserted because of pneumothorax on the third day of life. The second case had been referred with respiratory distress syndrome, and bilateral pneumothorax was present on admission. Upon follow up, the cases' clinical condition worsened; acute respiratory distress syndrome and massive pulmonary haemorrhage developed. After Stenotrophomonas maltophilia was isolated in blood cultures, the cases were treated successfully using a combination of trimethoprim/sulfamethoxazole and fluoroquinolone.

Antibacterial Activity of Stenotrophomonas maltophilia Endolysin P28 against both Gram-positive and Gram-negative Bacteria

“…Stenotrophomonas maltophilia is a Gram-negative bacillus and increasingly being recognized as an important nosocomial pathogen ( Looney et al, 2009 ; Brooke, 2012 ). It can cause serious infections such as bacteremia, pneumonia, endocarditis, meningitis, urinary tract infections, skin and soft tissue infections in immunocompromised patients ( Falagas et al, 2009 ; Sood et al, 2013 ; Hotta et al, 2014 ; Trignano et al, 2014 ; Guzoglu et al, 2015 ). The available therapeutic option for invasive S. maltophilia infection is limited, as this pathogen shows high levels of resistance to commonly used antibiotics ( Sánchez, 2015 ).…”

Fatal hemorrhagic pneumonia: Don’t forget Stenotrophomonas maltophilia

“…Hemorrhagic pneumonia by S. maltophilia develops in patients who have recently received chemotherapy or a hematopoietic stem cell transplant [5] . Eighty-four percent of these patients have bacteremia, and their clinical presentation is severe with 100% mortality within 72 hours of diagnosis [5] , [9] . Due to its severity and rapid progression, early suspicion is important; however, efforts for surveillance and prophylaxis are so far limited.…”

Hospital-Acquired Pneumonia Associated With the Causative Agent Stenotrophomonas Maltophilia, in Newborn Infants

“…На это заболевание приходится 20% от нозокомиальных инфекций [1]. Хотя проблеме ИВЛ-ассоциированной пневмонии у недоношенных новорожденных детей посвящено много научных ис-следований [1][2][3][4][5][6], однако особенности клинического течения заболевания, в том числе с учетом этиологи-ческого фактора, изучены мало [7][8][9].…”

“…Эпидемиологическое значение этого микроор-ганизма во многом связано с его биологическими свойствами, а именно с формированием и быстрым распространением новых госпитальных штаммов, их полирезистентностью к антибиотикам, способ-ностью длительно сохраняться на поверхностях объектов внешней среды, в том числе в деталях ме-дицинской техники [7][8][9]. Массивная колонизация организма новорожденного штаммами Sten.…”