Haemorrhagic septicaemia vaccines

Verma, Rishendra; Jaiswal, T. N.

doi:10.1016/s0264-410x(98)80118-7

Cited by 71 publications

(58 citation statements)

References 28 publications

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“…Various vaccine types have been developed among which the broth bacterin, the oil adjuvant vaccine, the double emulsion vaccine and a live vaccine (Verma and Jaiswal, 1998). e latter is a deer strain aerosol vaccine developed in Myanmar.…”

Section: Measures During An Outbreakmentioning

confidence: 99%

Haemorrhagic septicaemia, its significance, prevention and control in Asia

Benkirane¹,

Alwis²

2002

Vet. Med.

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ABSTRACT:Haemorrhagic septicaemia (HS) is an endemic disease in most countries of Asia and sub-Saharan Africa. Within the Asian Region, countries can be classified into three categories, on the basis of incidence and distribution of the disease; these are respectively countries where the disease is endemic or sporadic, clinically suspected but not confirmed, or free. Economic losses due to HS are not only confined to losses to the animal industry, but also rice production on account of its high prevalence among draught animals used in rice fields. Only a few attempts have been made to estimate economic losses, the methodologies used in different countries have varied, and many are not based on active surveillance, and a consideration of all components of direct and indirect losses. Most Asian countries rank HS as the most important contagious disease or the most important bacterial disease in cattle and buffaloes. Resource allocation for prevention and control of HS nationally or internationally will evidently depend on a correct estimate of its economic impact. e key factors in prevention and control would be timely and correct reporting, accurate and rapid diagnosis, strategic use of vaccines with the attainment of a high coverage where necessary with a high quality vaccine. National level activities geared towards attainment of these objectives may be with advantage supported and strengthened by international organisations involved in animal health. e present paper attempts to review aspects related to the epidemiology, control and containment of HS in Asia and, proposes some key issues on which a regional programme for HS control in this continent should be centred.

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Section: Measures During An Outbreakmentioning

confidence: 99%

Haemorrhagic septicaemia, its significance, prevention and control in Asia

Benkirane¹,

Alwis²

2002

Vet. Med.

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“…Some control is achieved with alum-precipitated or oil-adjuvanted killed whole-cell vaccines injected subcutaneously (s.c.), but these vaccines have the disadvantage of providing only short-term immunity (7) and require annual administration for effectiveness (10). The oil-adjuvanted vaccines have the added disadvantage of high viscosity, which makes them unpopular among field users, although improved oil-adjuvanted vaccines with lower viscosities have been described (29,34,35). However, all such vaccines suffer from a requirement for high numbers of inactivated cells (10 10 to 10 11 cells) and consequent problems of reactogenicity.…”

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confidence: 99%

Protective Immunity Conferred by AttenuatedaroADerivatives ofPasteurella multocidaB:2 Strains in a Mouse Model of Hemorrhagic Septicemia

et al. 2002

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Hemorrhagic septicemia (HS) is a fatal systemic disease of cattle and buffaloes. In South Asia HS is caused by infection with Pasteurella multocida serotype B:2. Some control is achieved with alum-precipitated or oil-adjuvanted killed whole-cell vaccines injected subcutaneously, but these vaccines provide only short-term immunity and require annual administration for effective use. Live attenuated vaccines have the advantage of a natural route of entry into the host, but for live strains to be used as vaccines, the mode of attenuation should be well defined. We constructed aroA attenuated derivatives of two P. multocida serotype B:2 strains by allelic exchange of the native aroA sequence with aroA sequences disrupted with a kanamycin resistance cassette or with marker-free aroA sequences containing an internal deletion. These strains were confirmed to be aroA mutants by PCR and Southern blot analysis, enzyme assay, and lack of growth on minimal medium. The aroA derivatives were highly attenuated for virulence in a mouse model of HS. Mouse challenge experiments showed that intraperitoneal or intranasal vaccination of an aroA strain completely protected mice against challenge with a high dose (>1,000 50% lethal doses) of either the parent strain or the other wild-type B:2 strain. The spread of the parent and the aroA derivatives to different organs was compared when the organisms were inoculated by different routes.

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“…P. multocida strains can be separated into serogroups A, B, D, E, and F based on the antigenicity of their capsule (6,26) and serotypes 1 to 16 based on lipopolysaccharide (LPS) antigens (12). The capsular serogroup is generally related to disease predilection, with hemorrhagic septicemia strains belonging to serogroup B or E (30) and the majority of fowl cholera strains belonging to serogroup A (7).…”

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confidence: 99%

“…It is considered to be the most economically important disease of livestock in South East Asia and causes significant economic losses in India and Africa (2,30). Cattle and buffalo are the most common hosts, but pigs, sheep, goats, deer, and camels are also susceptible to infection and disease (3,9).…”

mentioning

confidence: 99%

“…Cattle and buffalo are the most common hosts, but pigs, sheep, goats, deer, and camels are also susceptible to infection and disease (3,9). Vaccination with undefined, killed vaccines is practiced in areas where the disease is endemic and has reduced the incidence of disease, but the duration of immunity is short and significant outbreaks still occur (2,30). Little is known about why vaccination procedures sometimes fail.…”

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confidence: 99%

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Acapsular Pasteurella multocida B:2 Can Stimulate Protective Immunity against Pasteurellosis

Boyce

Adler

2001

Infect Immun

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We have previously shown that a Pasteurella multocida cexA mutant (PBA875) was impaired in capsule export and highly attenuated in virulence for mice (J. D. Boyce and B. Adler, Infect. Immun. 68:3463-3468, 2000). In this study we show that immunization with high, but not low, doses of PBA875 can confer significant protection against wild-type challenge. We have also constructed a genetically defined acapsular P. multocida strain (AL18) by inactivation of bcbH, a gene predicted to be involved in polysaccharide biosynthesis. AL18 failed to produce immunoreactive polysaccharide as determined by immunofluorescence and Western immunoblot. Immunization of mice with live AL18 conferred significant protection against wild-type challenge, while immunization with similar doses of either killed wild-type or killed AL18 failed to confer protection.

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Haemorrhagic septicaemia vaccines

Cited by 71 publications

References 28 publications

Haemorrhagic septicaemia, its significance, prevention and control in Asia

Haemorrhagic septicaemia, its significance, prevention and control in Asia

Protective Immunity Conferred by AttenuatedaroADerivatives ofPasteurella multocidaB:2 Strains in a Mouse Model of Hemorrhagic Septicemia

Acapsular Pasteurella multocida B:2 Can Stimulate Protective Immunity against Pasteurellosis

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