Haemostasis and parturition revisited: Comparative profiles in mammals

Gentry, Patricia A.; Feldman, Bernard F.; Liptrap, R.M.

doi:10.1007/bf00515662

Cited by 7 publications

(5 citation statements)

References 44 publications

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“…Bazzano et al (2014c), in a study on mares in the gestation and postpartum period, obtained a higher concentration of fibrinogen around delivery. Gentry et al (1991), in a study on healthy mares, observed that the values of fibrinogen increased gradually until delivery. Oliveira (2013) explained that an increase in the value of fibrinogen after calving may be the consequence of an inflammatory process that takes place in the uterus, however, in the present study, the mares did not present this kind of response.…”

Section: Discussionmentioning

confidence: 95%

Hematological and biochemical profiles of Mangalarga Marchador mares in the transition period bred on pasture

Silva

Filho

Dantas

et al. 2019

Arq. Bras. Med. Vet. Zootec.

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The present study aimed to evaluate the effects of the transition period on hematological and biochemical constituents in Mangalarga Marchador mares. Forty-eight mares were used to form a maintenance group (MG) and transition group (TG), formed by pregnant mares and, after delivery, infants. Blood samples were collected at the following times: T-60 (60 d pre-delivery), T-30 (30 d pre-delivery), T-15 (15 d predelivery), T0 (first 6h post-delivery), T15 (15 d post-delivery), T30 (30 d post-delivery), and T60 (60 d post-delivery). The TG had lower values (P< 0.05) of red blood cells, hematocrit and hemoglobin at T0, T15, T30 and T60 times than MG. The mean corpuscular volume was lower in MG (P< 0.05) than in TG (T0, T15, T30 and T60) and mean corpuscular hemoglobin concentration was higher (P< 0.05) in MG than in TG (T15, T30 and T60). On the other hand, the diameter distribution of red blood cells presented a lower value (P< 0.05) in MG than in TG (T15 and T30). Mares in transition period presented regenerative anemia. The results demonstrate physiological metabolic variations of different intensities during pregnancy, delivery and early lactation. RESUMOO presente estudo teve como objetivo avaliar os efeitos do período de transição em constituintes hematológicos e bioquímicos em éguas Mangalarga Marchador. Foram utilizadas 48 éguas para formar um grupo de manutenção (GM) e um grupo de transição (GT), composto por éguas gestantes e, após o parto, lactentes. Amostras de sangue foram coletadas nos seguintes tempos: . Éguas em período de transição apresentam anemia regenerativa. Os resultados demonstram variações metabólicas de diferentes intensidades durante a gestação, o parto e o início de lactação.

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Section: Discussionmentioning

confidence: 95%

Hematological and biochemical profiles of Mangalarga Marchador mares in the transition period bred on pasture

Silva

Filho

Dantas

et al. 2019

Arq. Bras. Med. Vet. Zootec.

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“…There is a scientific consensus that the activation of coagulation system in the uteroplacental circulation prepares this circulation against excessive fibrin accumulation (O' Riordan and Higgins, 2003). Fibrinogen levels have been reported to increase in cows and dogs during mid-pregnancy and postpartum (Gentry et al, 1991). D-dimer is formed as a consequence of the degradation of cross -linked fibrin clot by plasmin through activation of coagulation system for no apparent reason.…”

Section: Discussionmentioning

confidence: 99%

“…Although literature exists in evaluating some of the coagulation parameters in different stages of gestation in pregnant cows, there is a lack of research presenting the coagulation parameters of cows with embryonic losses (Gentry et al, 1991;Heuwieser et al, 1990a;Heuwieser et al, 1990b). Therefore, this study was conducted to investigate the relationship between coagulation parameters and embryonic loss in embryo transferred (ET) Holstein breed cows and heifers.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Relationship Between Coagulation Parameters and Embryonic Loss in Embryo Transferred Cows and Heifers

Aslan

Gürbulak

Kara

et al. 2021

Erciyes Üniversitesi Veteriner Fakültesi Dergisi

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The aim of the study, the relationship between coagulation parameters and embryonic loss in embryo transferred (ET) cows and heifers wereevaluated. The animal material of this study consisted of 19 cows and 19 heifers on farms located in East Mediterranean Agriculture Research Institute in Adana. Blood samples were collected before the ET application from the recipient cows and heifers. Coagulation parameters measured included prothrombin time (PT), activated thromboplastin time (APTT), fibrinogen, thrombin time (TT), anti-thrombin-III (AT3) and D-dimer using by Sysmex ® CA-7000 and activated protein C resistance, protein C and protein S using by Sysmex CS-5100. The pregnancy rate was found 5/19 (26.3%) and 5/19 (26.3%) in cows and in heifers, respectively (P>0.05). The embryonic mortality ratio in cows was 60% (3/5) and in heifers it was 40% (2/5). The differences of D-dimer levels between pregnant and non-pregnant animals were significant (P<0.05).The APTT levels between the groups with pregnancy and embryonic loss were significantly different (P<0.05). As a result, it was determined that there is a relationship between plasma D-Dimer levels and embryonic loss in cows that were transferred embryo.To the best of authors' knowledge, this is the first study reporting the relationship between coagulation parameters and embryonic loss in ET cows and heifers.

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“…DIC may occur in association with dystocia, eclampsia, Caesarean section, and retained Disseminated Intravascular Coagulation (DIC) 215 fetal placenta (Dodds 1985;Braun et al 1990). A physiological potential hypercoagulable state has been reported to be associated with parturition (Murano and Bick 1980;Gentry et al 1991). The proposed mechanisms that initiate DIC in obstetric complications include: (1) the release of amniotic fluid (with activity similar to thromboplastin, platelet factor 3 or phospholipoprotein into maternal circulation) (Lockwood et al 1991;Parihar et al 1991); (2) release of placental enzymes or tissues with thromboplastin-like activity into the maternal circulation (Bick 1985;Braun et al 1990;Wagner et al 1990;Suchartwatnachai et al 1991); and (3) release of necrotic fetal tissue or enzymes (with activation of the maternal haemostasis) into the maternal circulation (Angelov 1989;Bosner et al 1989;Braun et al 1990).…”

Section: Obstetric Complicationsmentioning

confidence: 99%