Haemostatic effects of phytoestrogen genistein in postmenopausal women

Trifiletti, A; Gaudio, Agostino; Lasco, Antonino; Atteritano, Marco; Scamardi, R; Pizzoleo, Maria Antonia; Morabito, Nunziata; Frisina, N

doi:10.1016/j.thromres.2008.02.009

Cited by 6 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results appear to conflict with the data on human plasma levels of haemostatic activation which indicate that isoflavones including genistein have no effect on haemostasis (13) or may even decrease the level of some markers of haemostatic activation (12,14). There are inherent difficulties in controlling soy intake in human studies which explain how, in several reports, the placebo groups show changes in coagulation activation which are not dissimilar to the study group (13,14). In addition some of these studies used a combination of phytoestrogens rather than a pure genistein supplement (12,13).…”

Section: Discussioncontrasting

confidence: 99%

“…Although the aetiology of the increased risk of VT is not understood, our group (10) and others (11) have shown that estradiol used in HT can modulate the inhibitors and activators of the haemostatic system. Some small studies have shown that genistein taken in the diet or as a dietary supplement has a neutral or antithrombotic effect; however, data is scarce and the quality and amount of genistein consumed varied widely between studies (12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Genistein alters coagulation gene expression in ovariectomised rats treated with phytoestrogens

Kelly¹,

O’Leary²,

Seidlová-Wuttke³

et al. 2010

Thromb Haemost

View full text Add to dashboard Cite

SummaryRecent data has shown that hormone therapy (HT) increases the risk of cardiovascular and thromboembolic disease, particularly in users of oral HT. Phytoestrogens are popular alternatives to oestrogen therapy; however, their effects on cardiovascular risk are unknown. We investigated the effect of the phytoestrogen, genistein on the expression of genes and proteins from the haemostatic system in the liver in an ovariectomised rat model. Fifty-nine virgin female Sprague-Dawley rats were fed with soy-free chow supplemented with 17β estradiol (E2) (daily uptake 0.19 or 0.75 mg/kg body weight), or genistein (daily uptake 6 or 60 mg/kg body weight), for three months and compared to soy-free control rats. Gene expression of prothrombin, factor VII, fibrinogen alpha and fibrinogen beta was increased with E2 and genistein compared to the soy-free control group (p<0.001). Genistein increased factor VII significantly more than E2 (p<0.005). Plasminogen mRNA was increased in both treatment groups compared to the soy-free control, with genistein expression significantly higher than E2 (p<0.001). Tissue plasminogen inhibitor (tPA), plasminogen activator inhibitor-1 (PAI-1) and C-reactive protein (CRP) expression were also increased in both groups relative the soy-free control. Results of protein analysis largely concurred with those of the mRNA. Oestrogen receptor β (ERβ) was undetected while oestrogen receptor α (ERα) was detected in each sample group. Genistein can increase the expression of coagulation and fibrinolytic genes. This effect was similar and in some cases higher than 17β estradiol. These results suggest that genistein may not be neutral with respect to the haemostatic system.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Genistein alters coagulation gene expression in ovariectomised rats treated with phytoestrogens

Kelly¹,

O’Leary²,

Seidlová-Wuttke³

et al. 2010

Thromb Haemost

View full text Add to dashboard Cite

show abstract

“…The conclusion of Triffileti´s group work was to claim that genistein is capable not only to inactivate hemostatic system, but it reduces DD levels, which can positively affect the hemostatic system. These results pointed out to cardioprotective function of genistein (Trifiletti et al 2008). Studies have shown biphasic effect of genistein on the growth MCF-7 cell line.…”

Section: Genisteinmentioning

confidence: 56%

“…Genistein also inhibits mammalian DNA topoisomerase II in mouse leukemia cells L-1210L- (Davis et al 2008, inhibits angiogenesis and has also genotoxic effects (Magee et al 2004). Trifiletti et al (2008) have found that although genistein has only a similar structure when compared to estradiol, it binds to ERs and can act as a selective estrogen receptor modulator, but its procoagulant effects are rather different of estrogen. Genistein is incapable to modify prothrombin levels (F1+2), but it significantly reduces D-dimer levels (DD).…”

Section: Genisteinmentioning

confidence: 99%

Nuclear receptors – target molecules for isoflavones in cancer chemoprevention

Bialešová

Brtko²,

Lenko³

et al. 2013

gpb

View full text Add to dashboard Cite

Breast cancer is the most occurring type of cancer among women. In Slovakia, there are yearly diagnosed about 1900 new cases of this disease. Breast cancer treatment is very expensive, psychic stressful and in some cases ineffective. Therefore, it is essential to search for new and/or alternative methods for breast cancer treatment, since nuclear receptors are considered to be a central goal for maximizing treatment opportunities in breast cancer. Among natural ligands for estrogen receptors (ERα and ERβ), which are member of nuclear receptors superfamily, belongs also isoflavones. These natural compounds have similar structure to main female hormon-17β estradiol. A rich source of isoflavones is soy and its products. Three aglycones form of isoflavones (genistein, daidzein, glycitein) are predominantly found in soybean and red clover. Among other important isoflavones belongs also biochanin A and formononetin.

show abstract

Genistein effects on quality of life and depression symptoms in osteopenic postmenopausal women: a 2-year randomized, double-blind, controlled study

et al. 2013

View full text Add to dashboard Cite

show abstract

Haemostatic effects of phytoestrogen genistein in postmenopausal women

Cited by 6 publications

References 25 publications

Genistein alters coagulation gene expression in ovariectomised rats treated with phytoestrogens

Genistein alters coagulation gene expression in ovariectomised rats treated with phytoestrogens

Nuclear receptors – target molecules for isoflavones in cancer chemoprevention

Genistein effects on quality of life and depression symptoms in osteopenic postmenopausal women: a 2-year randomized, double-blind, controlled study

Contact Info

Product

Resources

About

Haemostatic effects of phytoestrogen genistein in postmenopausal women

Cited by 6 publications

References 25 publications

Genistein alters coagulation gene expression in ovariectomised rats treated with phytoestrogens

Genistein alters coagulation gene expression in ovariectomised rats treated with phytoestrogens

Nuclear receptors – target molecules for isoflavones in cancer chemoprevention

Genistein effects on quality of life and depression symptoms in osteopenic postmenopausal women: a 2-year randomized, double-blind, controlled study

Contact Info

Product

Resources

About

Nuclear receptors – target molecules for isoflavones in cancer chemoprevention