Haemovigilance data on the use of methylene blue virally inactivated fresh frozen plasma with the Theraflex MB‐Plasma System in comparison to quarantine plasma: 11 years' experience

Abstract

Haemovigilance over 11 years has demonstrated the long-term safety of MB-FFP in comparison to untreated quarantine FFP. In addition to lowering the adverse event rate, implementing the system on a national scale in at-risk countries would presumably reduce the transmission of severe viral infections including emerging infectious diseases by transfusion.

Development of High Hydrostatic Pressure Applied in Pathogen Inactivation for Plasma

“…This results indicated factor V should also be concerned in HHP treatment. Some plasma PRTs also affected other plasma proteins like MB treatment decreasing fibrinogen level and the S/D process resulting in a high loss of protein S [29, 30]. In our experiments, we did not find these damages.…”

British Society of Haematology Guidelines on the spectrum of fresh frozen plasma and cryoprecipitate products: their handling and use in various patient groups in the absence of major bleeding

“…Analysis of reactions to MBFFP from Serious Hazard Of Transfusion (SHOT) data (2007‐2013) has not demonstrated a statistically significant increase in overall acute transfusion reactions, and non‐severe or severe allergic reactions when compared to standard FFP (Joint United Kingdom Blood Transfusion Services and Health Protection Agency Professional Advisory Committee, ). Therefore, MBFFP continues to be used in the UK and other countries, with no concerns about safety (Politis et al , ).…”

Dengue and chikungunya viruses in plasma are effectively inactivated after treatment with methylene blue and visible light

“…The THERAFLEX MB‐Plasma system, utilizes methylene blue (MB) and light at 630 nm to intercalate into the RNA/DNA backbone and cause nucleic acid breakages from oxidized guanosine upon excitation . This system is currently in use in several European countries . The THERAFLEX MB‐Plasma system has been shown to inactivate various viruses including hepatitis C virus (HCV) and WNV; however, no studies to date have examined DENV or CHIKV infectivity after treatment.…”