Hailey–Hailey Disease: An Update Review with a Focus on Treatment Data

Improvement in Hailey–Hailey disease with a combination of low-dose naltrexone and oral magnesium chloride: A case report

“…Low-dose naltrexone and oral magnesium chloride represent emerging treatments. 5,8 It is believed that naltrexone, a μ-opioid receptor antagonist, modulates opioid receptors expressed in keratinocytes, resulting in increased cellular adhesion. 9 Moreover, it exerts anti-inflammatory effects by antagonizing toll-like receptor 4.…”

“…4 Multiple treatments with various efficacy have been described, including topical corticosteroids and calcineurin inhibitors, oral antibiotics, retinoids, immunosuppressive agents and procedural methods such as lasers and dermabrasion. 5 Herein, we present a case of long-standing and recurrent inguinal HHD who significantly improved with a combination of low-dose naltrexone and oral magnesium chloride.…”

Improvement of Hailey–Hailey disease with low‐dose naltrexone

“…These include topical glucocorticoids, antimicrobials and calcineurin inhibitors; intralesional botulinum toxin injections; oral antibiotics; and destructive therapies including carbon dioxide laser and surgical excision. Systemic therapies such as methotrexate and acitretin are often tried in recalcitrant cases, with varying results …”

Botulinum toxin in treating Hailey‐Hailey disease: A systematic review

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Hailey-Hailey disease, also called benign familial chronic pemphigus, is a rare autosomal dominant disorder characterized by recurrent painful blistering, erosions, maceration in the intertriginous regions. 1,2 Hailey-Hailey disease is caused by mutations in the ATP2C1 gene located on chromosome 3q21-q24, whose function is to transport Ca 2+ /Mn 2+ into the Golgi apparatus and maintain normal intracellular concentrations of Ca 2+ /Mn 2+3 . The appearance of "dilapidated brick wall" was a characteristic histopathologic change of Hailey-Hailey disease.

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