Hair cell counts in an age-graded series of rat cochleas

Keithley, Elizabeth M.; Feldman, Martin L.

doi:10.1016/0378-5955(82)90017-x

Cited by 156 publications

(68 citation statements)

References 22 publications

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“…A significant age-related hair cell loss connected with a pronounced hearing threshold shift was reported previously in different strains of rats [40,57,58] as well as in human [59]. Specifically in Long Evans rats, Popelář el al.…”

Section: Accepted M Manuscriptmentioning

confidence: 72%

Age-related changes in auditory temporal processing in the rat

Šuta

Rybalko

Pelánová

et al. 2011

Experimental Gerontology

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ACCEPTED MANUSCRIPTABBREVIATIONS: dB SPL -dB sound pressure level, GDDL -gap duration difference limen, GDT-gap detection threshold, MLR -middle latency response ABSTRACT Presbycusis, as the deterioration of hearing ability occurring with aging, can be manifested not only in a shift of hearing thresholds, but also in a deterioration of the temporal processing of acoustical signals, which may in elderly people result in degraded speech comprehension.In this study we assessed the age-related changes in the temporal processing of acoustical signals in the auditory system of pigmented rats (Long Evans strain). The temporal resolution was investigated in young adult (3-4 months) and old (30-34 months) rats by behavioral and electrophysiological methods: the rats' ability to detect and discriminate gaps in a continuous noise was examined behaviorally, and the amplitude-rate function was assessed for the middle latency response (MLR) to clicks. A worsening of the temporal resolution with aging was observed in the results of all tests. The values of the gap detection threshold (GDT) and the gap duration difference limen (GDDL) in old rats increased about two-fold in comparison with young adult rats. The MLR to a click train in old rats exhibited a significantly faster reduction in amplitude with an increasing stimulation rate in comparison with young adult rats. None of the age-related changes in the parameters characterizing temporal resolution (GDT, GDDL and MLR to a click train) correlated with the degree of the age-related hearing loss. However, the age-related changes in MLR amplitude-rate function correlated with the age-related changes in GDDL, but not with the changes in GDT. The behavioral and electrophysiological data clearly show that aging in rats is accompanied with a pronounced deficit in the temporal processing of acoustical signals that is associated with the deteriorated function of the central auditory system.

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Section: Accepted M Manuscriptmentioning

confidence: 72%

Age-related changes in auditory temporal processing in the rat

Šuta

Rybalko

Pelánová

et al. 2011

Experimental Gerontology

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“…The factors influencing survival of SGCs in the mammalian cochlea have been studied by correlative histopathological analysis (Spoendlin 1975;Keithley and Feldman 1982;Suzuka and Schuknecht 1988;Sugawara et al 2005) and by molecular biological approaches (Stankovic et al 2004). Histopathological studies of acquired sensorineural hearing loss, in both animal models and human temporal bone material, have shown dramatic (950%) SGC degeneration in cochlear regions with massive hair cell loss (Leake and Hradek 1988;Miller et al 1997;McFadden et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Age-Related Primary Cochlear Neuronal Degeneration in Human Temporal Bones

Makary

Shin

Kujawa

et al. 2011

JARO

349

285

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“…Age-related morphological changes are minimum in the inner ear of the laboratory animals, including monkey [6,7], mouse [8], rat [12], chinchilla [2,4], rabbit [3] and guinea pig [5]. This is because these animals were kept in controlled environments of the laboratory [7].…”

Section: Animalsmentioning

confidence: 99%

Age-Related Changes in the Cochlea and Cochlear Nuclei of Dogs.

et al. 1998

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ABSTRACT. To study the underlying morphological changes of presbycusis, cochlea and cochlear nuclei from twenty three dogs, ranging in age from 3 days to 17 years, were examined histologically. Dogs used in this study were house dogs kept in an environment similar to that of humans. Four types of histological changes reported in human presbycusis, that is, loss of spiral ganglion cells, atrophy of the organ of Corti, atrophy of the stria vascularis, and thickening of the basilar membrane were observed in dogs. The changes were prominent at the base of the cochlea. Less intense changes were also observed in the apex of the cochlea. The degree of these changes appeared to progress as a function of age. All four types of changes with varied intensity were found in all dogs over 12 years old. In addition to the changes in the cochlea, cochlear nuclei changes including nerve cell loss, astrogliosis and ubiquitin deposition were found in dogs over 10 years old. Hearing dysfunction was accompanied by the morphological changes, though the degree of the hearing dysfunction did not always parallel to that of morphological changes. The morphological changes seen in the cochlea and cochlear nuclei of dogs were qualitatively and quantitatively similar to those reported in aged humans, indicating that otopathologic changes in the inner ear may be due to aging plus exposure to certain environmental ototoxic factors. -KEY WORDS: aging, canine, cochlea, cochlear nucleus, presbycusis.J. Vet. Med. Sci. 60(1): 41-48, 1998 ganglion neurons was responsible for hearing loss. These studies, however, were not designed to cover full anatomical regions in the cochlear pathology. The purpose of the present paper was to examine a wide variety of the agerelated morphological changes in the cochlea and cochlear nuclei of dogs reared in a similar environment to that of humans.

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Hair cell counts in an age-graded series of rat cochleas

Cited by 156 publications

References 22 publications

Age-related changes in auditory temporal processing in the rat

Age-related changes in auditory temporal processing in the rat

Age-Related Primary Cochlear Neuronal Degeneration in Human Temporal Bones

Age-Related Changes in the Cochlea and Cochlear Nuclei of Dogs.

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