Hair chromium concentration: effects of sample washing and external environment

Hambidge, K. Michael; Franklin, Michael L.; Jacobs, Margaret A.

doi:10.1093/ajcn/25.4.384

Cited by 60 publications

(23 citation statements)

References 23 publications

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“…The initial aim of this investigation was to determine the content of zinc in hair of apparently normal neonates, infants, children, and young adults who were living in Denver, Colorado. This was part of a more extensive evaluation of hair as a potential index of human trace mineral nutritional status [11][12][13]. After processing these initial analytical data, it was apparent that the population included a number of young children with exceptionally low levels of zinc in hair.…”

Section: Introductionmentioning

confidence: 99%

Low Levels of Zinc in Hair, Anorexia, Poor Growth, and Hypogeusia in Children

Km¹,

Hambidge²,

Jacobs³

et al. 1972

Pediatr Res

579

168

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ExtractConcentrations of zinc in hair were determined for 338 apparently normal subjects living in Denver with ages ranging from 0-40 years. Mean concentrations of zinc in hair were: neonates (25) 174 db 8 (1 SEM); 3 months^-years (93) 88 ± 5; 4-17 years (132) 153 ± 5, and 17^0 years (88) 180 ±4. Ten children more than 4 years of age had levels of zinc in hair of less than 70 ppm. Seven of these ten children had a history of poor appetite and eight had heights on or below the 10th percentile; the high incidence of low growth percentiles was not explicable on a familial basis. Taste acuity was tested in six of these children, and five had evidence of obj ective hypogeusia. After supplementing the diet with small quantities of zinc, taste acuity was normalized in each of these children and levels of zinc in hair increased. Speculation

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Section: Introductionmentioning

confidence: 99%

Low Levels of Zinc in Hair, Anorexia, Poor Growth, and Hypogeusia in Children

Km¹,

Hambidge²,

Jacobs³

et al. 1972

Pediatr Res

579

168

View full text Add to dashboard Cite

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“…The detergent solution contained negligible amounts of the analyzed elements and its use in the washing procedure does not It has been suggested that the trace metal content of hair may contribute to hair trace metal levels (15,18). The tubes were reflect the concentration of some trace elements both in animals agitated on a mechanical shaker for 30 min at room temperature, and man.…”

Section: Materials and Sample Preparationmentioning

confidence: 99%

“…removed by employing rigorously controlled washing procedures Analytical Procedure. The sealed polyethylene sample bags were (3,15,18). Fortunately, contamination effects should be minimal punctured to remove as much air as possible before irradiation.…”

mentioning

confidence: 99%

The Zinc, Copper, Manganese, Vanadium, and Iodine Content of Hair from 38 Canadian Neonates

Dewolfe

1979

Pediatr Res

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SummaryThe purpose of this investigation was to establish normal values Instrumental neutron activation analysis was used to establish "normal values" for the zinc, copper, manganese, vanadium, and iodine concentrations in washed hair samples from Canadian neonates. Sixteen males and 22 females (mean gestation of 40 wk; mean birthweight 3590 g) were included in the study. Their respective mean concentrations f SE (parts per million) were 224.0 f 6.29; 12.6 f 0.61; 0.24 f 0.04, 0.05 f 0.01; 24.3 f 4.76. AU the trace elements were normally distributed. No correlations of hair copper, zinc, and manganese with the variables sex, parity, and maternal socioeconomic status were found.A positive correlation for zinc with manganese (0.32; P = 0.024) was apparent, suggesting that the concentrations of these two elements at birth were interrelated.for the'zinc, copper, manganese, vanadium, and iodine concentrations of hair in 38 full term healthy Canadian neonates. Levels of these trace metals in hair may reflect body concentrations and, thus, provide an index for the detection of trace metal deficiencies at birth.There are very little data available on the trace metal concentrations in the hair of newborn infants although some exist for children and adults (6,7,10,16,17). Only small hair samples are available from neonates which makes analysis by atomic absorption, perhaps the most widely used method, difficult. Instrumental neutron activation was chosen for this investigation, being particularly suitable for the nondestructive multielement analysis of small hair samples.It is concluded that neonatal hair concentrations of copper, manganese, and vanadium were lower than most reported values METHODS for older children and adults. In contrast, the hair zinc concentration of the neonates in this study was higher than that of Denver SUBJECTS neonates, and may reflect higher body zinc concentrations, perhapsThe patients were 38 full term healthy infants of mean birthdue to regional differences in the trace metal content of the ground weight of 3590 g and mean gestational age of 40 wk, born in the water.Grace Maternity Hospital, Halifax, Nova Scotia. Sixteen were male and 22 were female. Speculation MATERIALS AND SAMPLE PREPARATIONThe establishment of normal values for the zinc, copper, manganese, vanadium, and iodine concentrations of neonatal hair Hair samples, cut close to the scalp at the back of the head were samples is essential before one can assess whether the hair levels taken 0-3 days after birth. Individual hair samples weighing reflect body concentrations at birth. Hair trace metal levels may approximately 20 mg were placed in acid-washed polyethylene provide an index for the detection of trace metal deficiencies at tubes and washed with 15 ml of a 1% solution of the nonionic birth. detergent, Actinox (34) according to the method of Hamson et al.. The detergent solution contained negligible amounts of the analyzed elements and its use in the washing procedure does not It has been suggested that the trace metal conte...

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“…Because impaired glucose tolerance was attributed to compromised Cr body stores, estimation of the Cr status in humans has become a most important task. Determination of Cr in blood [2,9,16,25,27,29 -41], hair [2,34,36,[42][43][44][45][46][47][48][49][50][51][52][53][54][55], and sweat [34,42,43,56] was carried out for that purpose. Changes in plasma Cr (P-Cr) in response to glucose challenge were measured, but the results of different research groups were inconsistent [9,15,27,29,36,57].…”

Section: Introductionmentioning

confidence: 99%

“…Changes in plasma Cr (P-Cr) in response to glucose challenge were measured, but the results of different research groups were inconsistent [9,15,27,29,36,57]. Very few data are available on sweat Cr [29,42,43,56], probably because of difficulties encountered in obtaining representative samples and associated contamination problems. Among various parameters measured to estimate Cr status, hair seems to be the most convenient because it is easily obtained, can be stored for a long period, and the concentration of Cr in hair is high enough to be accurately determined.…”

Section: Introductionmentioning

confidence: 99%