Hair cortisol and dehydroepiandrosterone and their associations with optimism and pessimism in older people

Zapater-Fajarí, Mariola; Crespo-Sanmiguel, Isabel; Montoliu, Teresa; Hidalgo, Vanesa; Salvador, Alicia

doi:10.1016/j.yhbeh.2023.105474

Cited by 3 publications

(2 citation statements)

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“…The biological stress response is manifested in activation of the hypothalamic-pituitary-adrenal (HPA) axis leading to the release of cortisol and androgens such as DHEAS, which in turn affect feeding control and metabolic balance [63]. Chronic biological stress responses have been shown to result in stressassociated changes in hair cortisol or DHEAS, often used as a measure of the biological stress response [38,39,64,65]. The hypothesis that plasma lipids reflect stress assumes that perceived stress is associated with biologically measurable parameters of stress.…”

Section: Discussionmentioning

confidence: 99%

“…Psychosocial stress is supposed to increase the secretion of glucocorticoids [34] and steroids [35] which promote insulin resistance, lipid imbalances and obesity, and increase the risk of cardiovascular diseases such as hypertension [36]. But perceived stress may not necessarily reflect the biological measurable levels of stress hormones such as cortisol in hair samples [37][38][39] or gonadal steroids [35]. There is evidence from previous and experimental studies that endogenous bioactive lipids contribute to the adaptations to chronic stress at the molecular level, and in turn, are regulated by chronic or acute stress.…”

Section: Introductionmentioning

confidence: 99%

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Sex, age, body mass index, and contraceptive use but not perceived stress influence healthy plasma lipidomic profiles

Hahnefeld,

Hackel,

Trautmann

et al. 2024

Preprint

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Background The stress of everyday life is thought to contribute to the pathogenesis of metabolic, vascular, mental, and immune diseases, with different susceptibilities in women and men. We hypothesized that sex differences in stress perception may manifest in sex-dependent lipid profiles. Methods The present study investigated the effect of sex, age, body mass index, perceived stress, regular and occasional drug use, and dietary supplements on plasma lipidomic profiles, obtained by mass spectrometry analyses. The study included 217 healthy women and 108 healthy men aged 18–68 years, who were recruited in a 2:1 female:male ratio to account for women with/without contraceptives. Results As expected, dehydroepiandrosterone sulfate (DHEAS) and ceramides were higher in men than in women, and in both sexes DHEAS decreased with age, while ceramides increased. Contrary to expectations, neither DHEAS nor ceramides were associated with perceived stress (PSQ30 questionnaire), which peaked in young and 51 + women (low in ages between), and in obese young men, whereas the overall male PSQ30 peak was around 40 years of age. None of the lipid species or classes showed a similar "age X sex X BMI" interaction. Strong sex differences were found for lysophosphatidylcholines (LPCs) (low in women) and their metabolites, lysophosphatidic acids (LPAs) (high in women). The LPA:LPC ratio was particularly high in women receiving contraceptives suggesting a strong hormone-induced conversion of LPCs to LPAs via autotaxin, which was much higher in women than in men, and is known to trigger platelet aggregation. In addition, phosphatidylethanolamines (PE) were high in women. They are precursors of endocannabinoids such as palmitoylethanolamide (PEA), which was elevated in subjects with a medical history of hypertension and increased with the BMI. Conclusion The results reveal complex sex differences in perceived stress and lipidomic profiles, the latter being exacerbated by contraceptive use, but perceived stress and lipids were not directly correlated. Trial registration Not applicable

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sex, age, body mass index, and contraceptive use but not perceived stress influence healthy plasma lipidomic profiles

Hahnefeld,

Hackel,

Trautmann

et al. 2024

Preprint

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Longitudinal associations between well‐being, hair cortisol, and self‐reported health

Lawes,

Eid

2024

Applied Psych Health & Well

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This pre‐registered study examines the longitudinal relationships between well‐being, hair cortisol (a biomarker linked to poor health), and self‐reported health. Accumulated cortisol output over three months was determined quarterly over the course of one year using hair samples. Well‐being was assessed as affective well‐being (via experience sampling), cognitive well‐being (i.e., life satisfaction), and eudaimonic well‐being (via the Ryff Scales of Psychological Well‐Being). Self‐reported health was measured using one item on the current state of health. The longitudinal analyses allowed for disentangling initial between‐person differences from within‐person changes and were based on a large panel study of working‐age people (N = 726). The results indicate that hair cortisol levels were generally not associated with any of the examined well‐being facets, regardless of the level of analysis. Further, deviations from well‐being trait levels were not linked to subsequent within‐person changes in hair cortisol (and vice versa), challenging the notion that cortisol output is a key physiological pathway through which well‐being improves health. In contrast, self‐reported health was positively correlated with affective, cognitive, and eudaimonic well‐being at both the trait and within‐person levels, whereas deviations from well‐being trait levels were generally not associated with subsequent within‐person changes in self‐reported health, and vice versa.

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Healthy plasma lipidomic signatures depend on sex, age, body mass index, and contraceptives but not perceived stress

Hahnefeld,

Hackel,

Trautmann

et al. 2024

American Journal of Physiology-Cell Physiology

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Perceived stress is thought to contribute to the pathogenesis of metabolic, vascular, mental, and immune diseases, with different susceptibilities in women and men. The present study investigated if and how perceived stress and/or demographic variables including sex, age, body mass index, regular prescription drugs, occasional analgesics, or dietary supplements manifested in plasma lipidomic profiles, obtained by targeted and untargeted mass spectrometry analyses. The study included 217 healthy women and 108 healthy men, aged 18-68 years, who were recruited in a 2:1 female:male ratio to account for women with/without contraceptives. As expected, dehydroepiandrosterone sulfate (DHEAS) and ceramides were higher in men than women, and DHEAS decreased with age, while ceramides increased. Contrary to expectations, neither DHEAS nor ceramides were associated with perceived stress (PSQ30 questionnaire), which was however, associated with BMI in men, but not in women. None of the lipid species or classes showed a similar "age X sex X BMI" interaction, but the endocannabinoid palmitoylethanolamide (PEA) correlated with BMI and hypertension. Independent of perceived stress, lysophosphatidylcholines (LPCs) were lower in women than men, whereas LPC metabolites, lysophosphatidic acids (LPAs), were higher in women. The LPA:LPC ratio was particularly high in women using oral contraceptives suggesting a strong hormone-induced extracellular conversion of LPCs to LPAs, which is catalyzed by the phospholipase D, autotaxin. The results reveal complex sex differences in perceived stress and lipidomic profiles, the latter being exacerbated by contraceptive use, but perceived stress and lipids were not directly correlated.

show abstract

Hair cortisol and dehydroepiandrosterone and their associations with optimism and pessimism in older people

Cited by 3 publications

References 56 publications

Sex, age, body mass index, and contraceptive use but not perceived stress influence healthy plasma lipidomic profiles

Sex, age, body mass index, and contraceptive use but not perceived stress influence healthy plasma lipidomic profiles

Longitudinal associations between well‐being, hair cortisol, and self‐reported health

Healthy plasma lipidomic signatures depend on sex, age, body mass index, and contraceptives but not perceived stress

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