Hair Cortisol as a Biomarker of Stress Among a First Nation in Canada

Henley, Phaedra; Jahedmotlagh, Zahra; Thomson, Steven; Hill, Julie; Darnell, Régna; Jacobs, Dean; Johnson, Joyce M.; Williams, Naomi; Williams, Rosemary M.; Uum, Stan Van; Bend, John R.; Koren, Gideon

doi:10.1097/ftd.0b013e318292eb84

Cited by 31 publications

(23 citation statements)

References 61 publications

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“…For subsequent analysis, we combined the hair cortisol values from the different settlements in Naivasha and Mogotio, as they are similar sociodemographic settings, to investigate potential sources of stress. The average values for hair cortisol content from all settlement communities (639 ± 300 ng/g) were significantly higher than the those for a Canadian Caucasian group (299 ± 110 ng/g; one-way ANOVA, P = 0.0003; Table 1) we had previously evaluated (Henley et al 2013). The results of the simple difference between means tests and the standardized multiple linear regression coefficients (with mutual adjustment for all vari- ables) are presented in Table 2.…”

Section: Resultsmentioning

confidence: 51%

“…Cortisol levels in these matrices are also subject to significant daily physiological fluctuations, and thus, to characterize long-term stress, multiple samples must be taken, which is labour intensive for both participants and researchers. These setbacks make it difficult to measure chronic stress in large populations using the traditional matrices (Henley et al 2013).…”

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confidence: 99%

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Cultural and socio-economic conditions as factors contributing to chronic stress in sub-Saharan African communities

HenleyPhaedra

LowthersMegan

Koren

et al. 2014

Can. J. Physiol. Pharmacol.

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Stress is known to contribute to overall health status. Many individuals in sub-Saharan Africa are believed to be stressed about their employment, income, and health. This study aimed to investigate hair cortisol as a biomarker of chronic stress in settlement communities in Kenya. Hair samples were collected from 108 volunteers from settlement communities in Kenya. An enzyme-linked immunosorbent assay technique was used to measure hair cortisol concentrations. In parallel, a health survey was completed. The mean ± SD for the cortisol concentration in the hair of volunteers from the settlement communities in Naivasha was 639 ± 300 ng/g, which was higher than found for a Caucasian reference group (299 ± 110 ng/g; one-way ANOVA, P = 0.0003). There were no differences in hair cortisol concentrations between members of slum settlements adjacent to large floriculture farms in Naivasha (Karagita, Kamere/Kwa Muhia/DCK, and Kasarani) compared with those well-removed from all floriculture in Mogotio (Mogotio and Westlands/Katorongot). However, hair cortisol concentrations were significantly higher in females, divorced volunteers, those who made below minimum wage, and those who reported feeling unsafe collecting water or using sanitation facilities within these 2 settlement groups. We found no evidence for increased chronic stress (measured by hair cortisol content) between members of slum settlements adjacent to versus distant to large floriculture farms. Cultural and socio-economic conditions that prevail in much of sub-Saharan Africa were found to be factors contributing to chronic stress.

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Section: Resultsmentioning

confidence: 51%

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confidence: 99%

Cultural and socio-economic conditions as factors contributing to chronic stress in sub-Saharan African communities

HenleyPhaedra

LowthersMegan

Koren

et al. 2014

Can. J. Physiol. Pharmacol.

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“…Here, we also present group differences on factors that may influence HCC, as assessed by a one‐page survey on which mothers reported basic health and lifestyle information for themselves and their daughters. This survey has been used in previous hair cortisol research (Henley et al, ) and assesses relevant factors such as pregnancy, hair‐washing frequency, hair dying or bleaching, height, weight, smoking, alcohol consumption, current medical conditions, and current medications (Gow, Thomson, Rieder, Van Uum, & Koren, ). Overall, most participants were Caucasian, which is consistent with population demographics of the region of Ontario from which families were recruited.…”

Section: Methodsmentioning

confidence: 99%

Hair cortisol concentrations in higher‐ and lower‐stress mother–daughter dyads: A pilot study of associations and moderators

Ouellette

Russell

Kryski

et al. 2015

Developmental Psychobiology

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Hair cortisol concentrations (HCC) are receiving increased attention as a novel biomarker of psychophysiological responses to chronic stress, with potential relevance for psychopathology risk research. We examined the validity of HCC as a marker of psychosocial stress in mother (M(age) = 37.87 years)-daughter (M(age) = 7.62 years) dyads characterized by higher (n = 30) or lower (n = 30) maternal chronic stress. Additionally, we examined whether early care moderated similarity of HCC levels within dyads. Higher-stress mothers had significantly lower HCC compared to lower-stress mothers, consistent with other research showing that chronic stress leads to blunted HPA axis activity over time. Further, HCC in daughters were significantly and positively associated with previously assessed salivary cortisol stress reactivity. Finally, mother-daughter HCC associations were significantly moderated by negative parenting styles, such that associations became stronger as quality of parenting decreased. Findings overall indicate that HCC may be a useful marker of cortisol responses to chronic stress.

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“…Long periods of stress were associated with increased hair cortisol concentrations (HCC) in animals (Davenport et al, 2006) and humans (review: Staufenbiel et al, 2013;original articles: O'Brien et al, 2012;Henley et al, 2013;Stalder et al, 2014). Furthermore, a range of studies have now provided direct and indirect support for the validity of HCC as measures of longterm cortisol secretion (Thomson et al, 2010;.…”

Section: Introductionmentioning

confidence: 95%

Determinants of maternal hair cortisol concentrations at delivery reflecting the last trimester of pregnancy

Braig

Grabher

Ntomchukwu

et al. 2015

Psychoneuroendocrinology

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Hair Cortisol as a Biomarker of Stress Among a First Nation in Canada

Cited by 31 publications

References 61 publications

Cultural and socio-economic conditions as factors contributing to chronic stress in sub-Saharan African communities

Cultural and socio-economic conditions as factors contributing to chronic stress in sub-Saharan African communities

Hair cortisol concentrations in higher‐ and lower‐stress mother–daughter dyads: A pilot study of associations and moderators

Determinants of maternal hair cortisol concentrations at delivery reflecting the last trimester of pregnancy

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