Hair cortisol in captive corral-housed baboons

Lutz, Corrine K.; Meyer, Jerrold S.; Novak, Melinda A.

doi:10.1016/j.ygcen.2020.113692

Cited by 5 publications

(7 citation statements)

References 48 publications

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“…Two characteristics of the present study and their potential effects on our results should be noted: (1) we utilized a crosssectional design to investigate cortisol concentration across age groups; and (2) we assayed cortisol via a state measure (hair) rather than a point measure (e.g., serum or urine). While previous studies on humans and nonhuman primates utilizing cross-sectional designs have reported similar findings of cortisol concentration decreasing with age (Feldman et al, 2002;Feller et al, 2014;Lutz et al, 2021;Nicolson et al, 1997) tration trajectories, and these differences are associated with cognitive decline trends (Ennis et al, 2017;Lupien et al, 1994). For example, Franz et al (2011) reported a significant association between cortisol levels and cognition in men aged 51-60, such that higher cortisol output was linked to poorer cognitive performance.…”

Section: Discussionmentioning

confidence: 64%

“…Research into the relationships between HCC and sex has revealed no consistent pattern across primate species. Females were reported to have higher HCC than males in baboons ( Papio hamadryas anubis : [Lutz et al, 2021], common marmosets [Garber et al, 2020], rhesus macaques [ Macaca mulatta ]; [Dettmer et al, 2014], and vervet monkeys [Laudenslager et al, 2012]); males showed higher HCC than females in humans (Dettenborn et al, 2012); and other studies have reported no sex differences (common marmosets [Phillips et al, 2018], chimpanzees [ Pan troglodytes ]: [Yamanashi et al, 2013], orangutans [ Pongo spp. ]: [Carlitz et al, 2014], Tonkean macaques [ M. tonkeana ], and long‐tailed macaques [ M. fascicularis ]: [Sadoughi et al, 2021]).…”

Section: Introductionmentioning

confidence: 99%

“…Although studies on aging of the HPA axis in nonhuman primates are limited, many species display age‐related declines in cortisol concentration (rhesus macaques [ M. mulatta ], vervet monkeys [ Chlorocebus aethiops ], and baboons [ Papio hamadryas ]), as measured via plasma and hair (Dettmer et al, 2014; Fourie & Bernstein, 2011; Goncharova & Lapin, 2004; Lutz et al, 2021). While these studies generally have not included aged or geriatric subjects, a recent longitudinal study examined age‐related changes in cortisol levels in wild chimpanzees ranging from approximately 10–63 years (Emery Thompson et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Cortisol levels across the lifespan in common marmosets (Callithrix jacchus)

Lopez,

Seidl,

Phillips

2024

American J Primatol

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Human aging is associated with senescence of the hypothalamic–pituitary–adrenal (HPA) axis, leading to progressive dysregulation characterized by increased cortisol exposure. This key hormone is implicated in the pathogenesis of many age‐related diseases. Common marmosets (Callithrix jacchus) display a wide spectrum of naturally occurring age‐related pathologies that compare similarly to humans and are increasingly used as translational models of aging and age‐related disease. Whether the marmoset HPA axis also shows senescence with increasing age is unknown. We analyzed hair cortisol concentration (HCC) across the lifespan of 50 captive common marmosets, ranging in age from approximately 2 months–14.5 years, via a cross‐sectional design. Samples were processed and analyzed for cortisol using enzyme immunoassay. HCC ranged from 1416 to 15,343 pg/mg and was negatively correlated with age. We found significant main effects of age group (infant, adolescent, adult, aged, very aged) and sex on HCC, and no interaction effects. Infants had significantly higher levels of HCC compared with all other age groups. Females had higher HCC than males. There was no interaction between age and sex. These results suggest marmosets do not show dysregulation of the HPA axis with increasing age, as measured via HCC.

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Section: Discussionmentioning

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cortisol levels across the lifespan in common marmosets (Callithrix jacchus)

Lopez,

Seidl,

Phillips

2024

American J Primatol

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“…This study used hair samples to measure hair cortisol levels, which provides a more reliable and long-term assessment of cortisol exposure than traditional methods such as serum, saliva, or urine cortisol levels. Hair cortisol analysis is being increasingly optimized and applied in both research and medicine ( 26 – 28 ) as it provides an objective and unique biomarker for analyzing endogenous cortisol levels and shows that the deposition of compounds and their metabolites in hair during growth allows retrospective quantification ( 29 ). In the present study, we investigated the association between hair cortisol levels and nutritional status among participants from the ELSA-Brasil cohort.…”

Section: Discussionmentioning

confidence: 99%

Hair cortisol levels are associated with overweight and obesity in the ELSA-Brasil cohort

Rodrigues,

Scaranni,

Pereira

et al. 2024

Front. Endocrinol.

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IntroductionHair cortisol level has recently been identified as a promising marker for detecting long-term cortisol levels and a marker of hypothalamic-pituitary-adrenal cortex (HPA) axis activity. However, research on the association between obesity and an altered cortisol metabolism remains controversial.ObjectiveThis study aimed to investigate the relationship between hair cortisol levels and overweight and obesity in participants from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)MethodsThis was a cross-sectional study involving 2,499 participants from the second follow-up (visit 3, 2017-2019) attending research centers in Rio de Janeiro and Rio Grande do Sul states. Hair samples were collected, and cortisol levels were analyzed using enzyme-linked immunosorbent assay (ELISA) kits. Cortisol levels were classified as low (< 40 pg/mg), medium (40–128 pg/mg), or high (> 128 pg/mg). The participants were classified as eutrophic, overweight, or obese according to their weight (kg) and height (m2). Odds ratios (ORs) with 95% confidence intervals (95%CI) were estimated.ResultsOf the 2499 individuals, 30% had eutrophic weight, 40% were overweight, and 30% were obese. Notably, cortisol levels gradually increased with increasing body weight. Among participants with high hair cortisol levels, 41.2% were classified as overweight and 34.2% as obese. Multinomial logistic regression analysis indicated that participants with high cortisol levels were 43% (OR =1.43; 95%CI: 1.02–2.03) more likely to be overweight and 72% (OR =1.72; 95%CI:1.20–2.47) more likely to be obese than participants with low hair cortisol levels. After adjustment for all covariates, high cortisol levels remained associated with obesity (OR = 1.54; 95%CI:1.02–2.31) and overweight (OR =1.33; 95%CI:0.91–1.94).ConclusionIn the ELSA-Brazil cohort, hair stress were positively associated with overweight and obesity. These results underscore the importance of considering stress and cortisol as potential factors in obesity prevention and intervention efforts, and highlight a novel aspect of the complex relationship between stress and obesity in the Brazilian population.

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“…Analysis of hair cortisol concentration is increasingly used to study HPA axis activity in response to prolonged stressful conditions and has proven to be a very informative tool for evaluating chronic stress and welfare in many animal species. However, the results can be influenced by numerous factors, such as genetic inheritance [91,92], species [93,94], physiological stage of development, life history, sex, age [94,95], environmental factors [67], pregnancy [95,96], and parturition [14], as well as methodological factors (storage time and conditions, localization of sample) and color [92]. Hair is a useful biomatrix for retrospective measurements of special analytes (e.g., cortisol) because small amounts of biological molecules present in blood can be deposited in it.…”

Section: Hairmentioning

confidence: 99%

Selection of appropriate biomatrices for studies of chronic stress in animals: a review

Ataallahi¹,

Lee²,

Park³

2022

J Anim Sci Technol

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Cortisol and corticosterone, hormones traditionally considered biomarkers of stress, can be measured in fluid biomatrices (e.g., blood, saliva) from live animals to evaluate conditions at sampling time, or in solid biomatrices (e.g., hair, feather) from live or dead animals to obtain information regarding long-term changes. Using these biomarkers to evaluate physiological stress responses in domestic animals may be challenging due to the diverse characteristics of biomatrices for potential measurement. Ideally, a single measurement from the biomatrix should be sufficient for evaluating chronic stress. The availability of appropriate and cost-effective immunoassay methods for detecting the biomarkers should also be considered. This review discusses the strengths and limitations of different biomatrices with regard to ensuring the highest possible reliability for chronic stress evaluation. Overall, solid biomatrices require less frequent sampling than other biomatrices, resulting in greater time-and cost-effectiveness, greater ease of use, and fewer errors. The multiplex immunoassay can be used to analyze interactions and correlations between cortisol and other stress biomarkers in the same biomatrix. In light of the lack of information regarding appropriate biomatrices for measuring chronic stress, this review may help investigators set experimental conditions or design biological research.

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Hair cortisol in captive corral-housed baboons

Cited by 5 publications

References 48 publications

Cortisol levels across the lifespan in common marmosets (Callithrix jacchus)

Cortisol levels across the lifespan in common marmosets (Callithrix jacchus)

Hair cortisol levels are associated with overweight and obesity in the ELSA-Brasil cohort

Selection of appropriate biomatrices for studies of chronic stress in animals: a review

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