Hair-follicle Transplant Into Chronic Ulcers: A New Graft Concept

Hair follicle stem cells promote epidermal regeneration under expanded condition

“…In the 1940s, researchers first reported that dedifferentiated cells from HFs contribute to wound healing, and superficial wounds where HFs remained intact healed faster ( Toma et al, 2021 ). Moreover, grafts containing HFs carrying HFSCs have shown great potential in promoting epidermal healing for the treatment of chronic cutaneous wounds ( Liu et al, 2015 ; Martínez et al, 2016 ; Martínez et al, 2017 ). HFSCs in the lower bulge region and the isthmus of the HF both can migrate to the injury sites and contribute to re-epithelialization during wound healing ( Nuutila et al, 2017 ; Burgy and Königshoff, 2018 ; Li et al, 2019 ).…”

Hair Follicle Grafting Therapy Promotes Re-Emergence of Critical Skin Components in Chronic Nonhealing Wounds

“…Both mesenchymal stem cells (MSCs) (Otero-Viñas and Falanga, 2016) and bone marrowderived stem cells (Badiavas and Falanga, 2003) have been employed for the management of cutaneous wounds. Autologous hair follicle grafting has recently been discovered as an efficacious therapy to stimulate closure of non-healing wounds [ (Jiménez et al, 2012), (Liu et al, 2015), (Martínez et al, 2016), (Martínez et al, 2017)]. The advantage of using hair follicle grafts over epidermal grafts or cultured keratinocytes is also established in the field, wherein hair follicle grafting is a more effective and technically easier method to treat chronic wounds (Nuutila, 2021;Yang et al, 2015;Weyandt et al, 2009).…”

Mini punch graft for chronic leg ulcers, case series

“…Chronic leg ulcer is a serious health problem in many country because of the high prevalence and high cost to health care system. [1][2][3] Chronic leg ulcer caused by diabetes mellitus is characterized by impaired wound healing. It can caused by decreased angiogenesis also decreased fibroblast and keratinocyte proliferation and migration.…”