Hair growth‐modulation by adrenergic drugs

Peters, Eva M.J.; Maurer, Marcus; Botchkarev, Vladimir A.; Gordon, D. S.; Paus, Ralf

doi:10.1111/j.1600-0625.1999.tb00382.x

Cited by 22 publications

(20 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, human HFeSC upregulate β1-adrenergic receptor (β1-AR; Ohyama et al, 2006). These expression data may carry particular hair-biological relevance, since beta-adrenergic receptor protein immunoreactivity in murine skin in vivo is up-regulated in the bulge region of pelage HF during the early growth phase of the hair cycle (anagen) (Botchkarev et al, 1999) and since catecholamines indeed modulate HF cycling in murine skin organ culture (Peters et al, 1999). Moreover, diffuse hair loss (telogen effluvium) is a fairly frequent, undesired clinical effect of betablocker pharmacotherapy (Shelley et al, 1985).…”

Section: Pointers From Hfesc Gene Profiling Studiesmentioning

confidence: 97%

“…A c c e p t e d M a n u s c r i p t Botchkarev et al, 1999Peters et al, 1999Souza et al, 2006 Alonso and Fuchs, 2006 Aminik et al, 2007Paus and Foitzik, 2004Schlake, 2005aSchlake, 2005bStenn and Paus, 2001 Weger and Schlake,…”

Section: Acknowledgementsmentioning

confidence: 99%

“…Peptides secreted by hypothalamic neuroendocrine neurons into the blood often appeared to complement with peripheral actions e.g in the HF it is believed to play a role in the pathogenesis of alopecia areata (Kim et al, 2006;Pritchard and White, 2007; Sivilia et al, 2008;Sun et al, 2007). Adrenaline and noradrenaline proved to have properties between endocrine cells and neurons, and demonstrated an outstanding model system for the instance of neuroendocrine systems in the HF (Botchkarev et al, 1999;Peters et al, 1999).The origins and significance of patterning in neuroendocrine secretion are still dominant themes in neuroendocrinology today.Cytokines act like hormones and neurotransmitters but whereas hormones are released from specific organs into the blood and neurotransmitters are produced by neurons, cytokines are released by many types of cells, like the interleukin-6 family member oncostatin M, which is a HF expressed factor with growth inhibitory properties (Yu et al, 2008). …”

mentioning

confidence: 99%

See 2 more Smart Citations

(Neuro-)endocrinology of epithelial hair follicle stem cells

Paus

Arck

Tiede

2008

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

The hair follicle is a repository of different types of somatic stem cells. However, even though the hair follicle is both a prominent target organ and a potent, non-classical site of production and/or metabolism of numerous polypetide-and steroid hormones, neuropeptides, neurotransmitters and neurotrophins, the (neuro-) endocrine controls of hair follicle epithelial stem cell (HFeSC) biology remain to be systematically explored.Focussing on HFeSCs, we attempt here to offer a "roadmap through terra incognita" by listing key open questions, by exploring endocrinologically relevant HFeSC gene profiling and mouse genomics data, and by sketching several clinically relevant pathways via which systemic and/or locally generated (neuro-)endocrine signals might impact on HFeSC. Exemplarily, we discuss e.g. the potential roles of glucocorticoid and vitamin D receptors, the hairless gene product, thymic hormones, bone morphogenic proteins (BMPs) and their antagonists, and Skg-3 in HFeSC biology. Furthermore, we elaborate on the potential role of nerve growth factor (NGF) and substance P-dependent neurogenic inflammation in HFeSC damage, and explore how neuroendocrine signals may influence the balance between maintenance and destruction of hair follicle immune privilege, which protects these stem cells and their progeny. These considerations call for a concerted research effort to dissect the (neuro)-endocrinology of HFeSCs much more systematically than before. The hair follicle (HF) and its special, associated mesenchyme (i.e. the connective tissue sheath, CTS) are repositories of different types of somatic stem cells (epithelial, mesenchymal, neural, mesenchymal) (Cotsarelis, 2006; Kruse et al., 2006;Millar, 2005;Ohyama et al., 2006;Tiede et al. 2007;Waters et al., 2007;Yu et al., 2006). These HFassociated stem cell populations are critical for HF development and function, including HF pigmentation (Nishimura et al., 2002(Nishimura et al., , 2005Sarin and Artandi, 2007). Fig. 1 shows several important, recognized hair follicle-associated stem cell populations and their bestcharacterized location(s) in the pilosebaceous unit, though it must be kept in mind that the indicated ones are unlikely to be the only stem cell population associated with mammalian skin appendages (Tiede et al. 2007). Clinical importance of hair follicle stem cellsHair follicle epithelial stem cells (HFeSCs) are clinically important, since they can be key targets for pathological processes, such as an autoaggressive inflammatory cell attack on HFeSC, e.g. in lupus erythematosus or lichen planopilaris, where the destruction of bulge HFeSCs (see Fig.1) abolishes the hair follicle's capacity to cycle and to rhythmically regenerate itself, leading to scarring alopecia (Cotsarelis, 2006;Hiroi et al., 2006;Mobini et al., 2005;Paus, 2006). Likewise, a gradual loss of HF melanocyte stem cells may exhaust the HF pigmentary unit's capacity to generate itself and to produce melanin and thus likely plays a key role in hair graying (Commo et al., 2004;...

show abstract

Section: Pointers From Hfesc Gene Profiling Studiesmentioning

confidence: 97%

Section: Acknowledgementsmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

(Neuro-)endocrinology of epithelial hair follicle stem cells

Paus

Arck

Tiede

2008

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

show abstract

“…The sum of scores per group was then divided by the number of investigated hair follicles. 36,37 The mean value of these scores therefore is a reliable quantitative indicator of the mean hair follicle stage that had been reached on average by a larger population of hair follicles after culture.…”

Section: Hair Cycle Stagingmentioning

confidence: 99%

p75 Neurotrophin Receptor-Mediated Signaling Promotes Human Hair Follicle Regression (Catagen)

Peters

Stieglitz

Liezman

et al. 2006

The American Journal of Pathology

View full text Add to dashboard Cite

Nerve growth factor (NGF) and its apoptosis-promoting low-affinity receptor (p75NTR) regulate murine hair cycling. However, it is unknown whether human hair growth is also controlled through p75NTR, its highaffinity ligand pro-NGF, and/or the growth-promoting high-affinity NGF receptor tyrosine kinase A (TrkA). In microdissected human scalp anagen hair bulbs, mRNA for NGF, pro-NGF, p75NTR, and TrkA was transcribed. Immunohistomorphometry and in situ hybridization detected strong NGF and pro-NGF expression in terminally differentiating inner root sheath keratinocytes, whereas TrkA was co-expressed with p75NTR in basal and suprabasal outer root sheath keratinocytes. During spontaneous catagen development of organ-cultured human anagen hair follicles, p75NTR mRNA levels rose, and p75NTR and pro-NGF immunoreactivity increased dramatically in involuting compartments primarily devoid of TrkA expression. Here, TUNEL ؉ apoptotic cells showed prominent p75NTR expression. Joint pro-NGF/ NGF administration inhibited hair shaft elongation and accelerated catagen development in culture, which was antagonized by co-administration of p75NTR-blocking antibodies. In addition, mRNA and protein expression of transforming growth factor-␤2 increased early during spontaneous catagen development, and its neutralization blocked pro-NGF/NGF-dependent hair growth inhibition. Our findings suggest that pro-NGF/NGF interacts with transforming growth factor-␤2 and p75NTR to terminate anagen in human hair follicles, implying that p75NTR blockade may alleviate hair growth disorders characterized by excessive catagen development. (Am J Pathol

show abstract

“…For example, decreased levels of ␤-〈Rs were observed in lesional and nonlesional skin of psoriasis patients (815), whereas increased levels of ␣-AR were observed in arterioles of patients with scleroderma (250). Moreover, the ␤-〈R appears to promote hair cycle progression (97,637). Finally, epinephrine as well as norepinephrine were able to increase LPS-induced IL-6 production in human microvascular endothelial cells via ␤ 1 -and ␤-ARs (279).…”

Section: Adrenergic Receptorsmentioning

confidence: 99%

Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ

Roosterman¹,

Goerge

Schneider

et al. 2006

Physiological Reviews

556

521

View full text Add to dashboard Cite

This review focuses on the role of the peripheral nervous system in cutaneous biology and disease. During the last few years, a modern concept of an interactive network between cutaneous nerves, the neuroendocrine axis, and the immune system has been established. We learned that neurocutaneous interactions influence a variety of physiological and pathophysiological functions, including cell growth, immunity, inflammation, pruritus, and wound healing. This interaction is mediated by primary afferent as well as autonomic nerves, which release neuromediators and activate specific receptors on many target cells in the skin. A dense network of sensory nerves releases neuropeptides, thereby modulating inflammation, cell growth, and the immune responses in the skin. Neurotrophic factors, in addition to regulating nerve growth, participate in many properties of skin function. The skin expresses a variety of neurohormone receptors coupled to heterotrimeric G proteins that are tightly involved in skin homeostasis and inflammation. This neurohormone-receptor interaction is modulated by endopeptidases, which are able to terminate neuropeptide-induced inflammatory or immune responses. Neuronal proteinase-activated receptors or transient receptor potential ion channels are recently described receptors that may have been important in regulating neurogenic inflammation, pain, and pruritus. Together, a close multidirectional interaction between neuromediators, high-affinity receptors, and regulatory proteases is critically involved to maintain tissue integrity and regulate inflammatory responses in the skin. A deeper understanding of cutaneous neuroimmunoendocrinology may help to develop new strategies for the treatment of several skin diseases.

show abstract

Hair growth‐modulation by adrenergic drugs

Cited by 22 publications

References 36 publications

(Neuro-)endocrinology of epithelial hair follicle stem cells

(Neuro-)endocrinology of epithelial hair follicle stem cells

p75 Neurotrophin Receptor-Mediated Signaling Promotes Human Hair Follicle Regression (Catagen)

Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ

Contact Info

Product

Resources

About