Hair-Growth-Promoting Effects of Fermented Red Ginseng Marc and Traditional Polyherb Formula in C57BL/6 Mice

Song, Phil Hyun; Park, Gyu-Ryeul; Kim, Yoon-Hae; Jung, Dae Hwa; Ku, Sae-Kwang; Song, Chang‐Hyun

doi:10.3390/app11031195

Cited by 7 publications

(4 citation statements)

References 48 publications

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“…Generally, growth factors such as IGF-1, VEGF, fibroblast growth factor, and keratinocyte growth factors stimulate the proliferation of hair cells, maintain the development of hair follicles, and enhance hair growth and hair shaft elongation. In contrast, other growth factors, such as TGF-β, fibroblast growth factor 5, and prostaglandin D2, can inhibit hair growth ( Herman and Herman, 2016 ; Park and Lee, 2021 ; Song et al, 2021 ). The results of the current study indicated that topical application of RHSO enhanced the level of IGF-1 in mouse skins ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Hair Growth-Promoting Effects of Rosehip (Rosa canina L.) Seed Oil in C57BL/6 Mice

Truong,

Jeong

2023

Prev. Nutr. Food Sci.

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Rosehip ( Rosa canina L.) seeds, a by-product of the food processing industry, contain various bioactive compounds that have potential cosmetic and pharmacological applications. Rosehip seed oil (RHSO) has been shown to exert therapeutic effects in skin disorders, but its role in promoting hair growth remains unknown. In this study, we aimed to elucidate the hair growth-promoting activity of RHSO and the related mechanisms of action. The depleted dorsal skin of telogenic C57BL/6 mice was topically treated with RHSO for 21 days, and the extent of hair regrowth was assessed. The results indicated that RHSO stimulated hair growth by inducing the early transition of hair follicles from telogen to anagen phase. Histological analysis revealed significant increases in hair follicle density, hair bulb size, and skin thickness. RHSO treatment also upregulated the expression of hair growth-associated genes, including β-catenin, phospho-glycogen synthase kinase-3 beta, Sonic hedgehog, smoothened, cyclin D1, cyclin E, and insulin like growth factor 1. These findings suggest that RHSO stimulates hair growth and may show promise as a preventive and/or therapeutic agent for hair loss.

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Section: Resultsmentioning

confidence: 99%

Hair Growth-Promoting Effects of Rosehip (Rosa canina L.) Seed Oil in C57BL/6 Mice

Truong,

Jeong

2023

Prev. Nutr. Food Sci.

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“…Promoting effects on the hair growth cycle [163] Carrot root Bacillus ginsengisoli Anti-oxidant, reduced skin dullness, anti-aging, anti-wrinkle [132] Radish root…”

Section: Bioferments In the Cosmetic Industrymentioning

confidence: 99%

Use of Waste from the Food Industry and Applications of the Fermentation Process to Create Sustainable Cosmetic Products: A Review

Krzyżostan,

Wawrzyńczak,

Nowak

2024

Sustainability

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In recent years, the sustainability of cosmetic products has received growing interest from the cosmetic industry and consumers due to the recommendation of the implementation of the circular economy and the European Green Deal. The sustainable development strategy takes into account the reduction of waste and energy consumption, and covers all processes of producing and using cosmetics, starting from the method of obtaining raw materials, through to the process of producing cosmetics bulk, to the selection of packaging. Particularly, the selection of raw materials has a large impact on sustainability of cosmetic emulsion. One way of resource recovery is the use of agro-food by-products and discarded waste to produce cosmetic raw materials, because most of them possess value-added bioactive compounds, such as enzymes and nutrients with high functionality. Their recovery may be performed by more sustainable extraction processes, leading to natural oils, extracts, polymers, phytosterols, vitamins, minerals, and unsaturated fatty acids. A relatively new and innovative form of designing sustainable and bioavailable cosmetic raw materials is fermentation, where bioferments are obtained from plant-based and food waste raw materials. In addition, optimization of the emulsification process by applying low-energy methods is a crucial step in obtaining sustainable cosmetics. This allows not only a reduction in the carbon footprint, but also the preservation of the valuable properties of the used raw materials. The following paper discusses methods of creating sustainable cosmetic emulsions with energy-saving procedures and by using raw materials from food waste and the fermentation process.

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“…Fermented RGM was provided by Punggi Ginseng Farming Corp. (Yeongju, Korea), and used as same lot number as that used in our previous study [25]. Briefly, 6-year-old Korean red ginseng was extracted by boiling in distilled water (DW) for 3 h at 80 °C, and the remaining RGM was dried and grinded.…”

Section: Preparation Of Fermented Rgmmentioning

confidence: 99%

“…Fermented RGM contains a greater proportion of ginsenosides, Rg2, Rg3 and Rh2 than the non-fermented RGM, which enhances its antioxidant activities and incidental favorable effects [23,24]. Our previous study has shown that topical treatment of RGM extracts fermented with a complex of microorganisms promotes hair growth [25]. The fermented RGM contained crude ginsenosides (1.7 mg/g) and polyphenols (9.8 mg/g), and the antioxidant activities were more than those of non-fermented form.…”

Section: Introductionmentioning

confidence: 99%

Anti-allergic Effects Of Fertilized Red Ginseng Marc On 2,4-dinitrochlorobenzene-induced Atopic Dermatitis-like Mice Model

Jung¹,

Choi²,

Park³

et al. 2022

Preprint

Self Cite

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Atopic dermatitis (AD) is a chronic and allergic skin disease, however, there is no cure for the disease. Many studies have shown anti-AD potentials of red ginseng, while red ginseng marc (RGM) remained after the ginseng extraction is discarded as industrial waste. However, it is recently reported that RGM, particularly fermented RGM (fRGM), still contains the bioactive properties. Thus, anti-allergic effects of fRGM were examined in 2,4-dinitrochlorobenzene-induced AD-like mice model. The model was topically treated with distilled water (control), dexamethasone, or fRGM for six weeks. The treatments of fRGM alleviated the skin lesions and reduced serum IgE levels, compared with the control. The fRGM also reduced skin levels of lipid peroxidation and superoxide anion, however, increased glutathione contents, with down-regulated gene expressions for inflammatory mediators. The histopathological analyses demonstrated that fRGM suppressed the epidermal thickening, collagen deposition, and inflammatory cell and mast cell infiltration, which involved the anti-inflammatory, anti-oxidant, and anti-apoptotic effects. Further, fRGM suppressed hypertrophic changes and inflammatory responses in the spleen and lymph node. The beneficial effects were observed in the dexamethasone and fRGM groups, however, the antioxidant effects were evident only in the fRGM treatments. These provide useful information for developing fRGM as therapeutic sources for AD.

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Hair-Growth-Promoting Effects of Fermented Red Ginseng Marc and Traditional Polyherb Formula in C57BL/6 Mice

Cited by 7 publications

References 48 publications

Hair Growth-Promoting Effects of Rosehip (Rosa canina L.) Seed Oil in C57BL/6 Mice

Hair Growth-Promoting Effects of Rosehip (Rosa canina L.) Seed Oil in C57BL/6 Mice

Use of Waste from the Food Industry and Applications of the Fermentation Process to Create Sustainable Cosmetic Products: A Review

Anti-allergic Effects Of Fertilized Red Ginseng Marc On 2,4-dinitrochlorobenzene-induced Atopic Dermatitis-like Mice Model

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