Hair loosening in Angora goats using cyclophosphamide

Wansley, R.G; Ericsson, S. A.; Corn, C.D.; Dart, M. G.; Crenshaw, Carlyle

doi:10.1016/s0921-4488(97)00088-6

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…In addition, Wansley et al . () found that an oral dose of 30 mg/kg CPA could be used as a hair‐loosening agent in Angora goats. Therefore, it can be surmised that the appropriate CPA dose is related to the administration method and the animal species.…”

Section: Discussionmentioning

confidence: 99%

The induction of cashmere shedding via cyclophosphamide injection

Chen

Yao

et al. 2017

Animal Science Journal

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The aim of this study was to investigate the effects of cyclophosphamide (CPA) on cashmere shedding in cashmere goats. Thirty-two castrated Liaoning cashmere goats were randomly allotted to four groups, with eight replicates in each group. The four groups were injected intravenously with CPA doses of 0, 15, 20 and 25 mg/kg body weight, respectively. Feed intake, body weight, body temperature, and sphygmus were recorded and the erythrocyte count, leukocyte count, hemoglobin content, and cashmere yield and length were determined. CPA has no significant effect on feed intake, body weight, body temperature, or sphygmus of cashmere goats. It was found that CPA significantly decreased the erythrocyte count and hemoglobin content in cashmere goats on the days immediately following injection, but the effects on erythrocytes diminished within 6 days, with hemoglobin content returning to normal within 10 days. Cashmere fiber began to shed on about day 10 after injection with CPA. CPA had no significant effect on cashmere length but significantly increased cashmere yield. The results indicate that CPA can induce cashmere shedding and achieve the purpose of concentrated defleecing. A dose of 20 mg/kg body weight is preferable for hair removal and regrowth in cashmere goats.

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Section: Discussionmentioning

confidence: 99%

The induction of cashmere shedding via cyclophosphamide injection

Chen

Yao

et al. 2017

Animal Science Journal

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“…Chen et al (1998) found that Xinjiang fine-wool sheep began shedding between days 6 and 8 following intramuscular injection with CPA at a dose of 30 mg kg −1 BW. In addition, Wansley et al (1998) reported that an oral dose of CPA at 30 mg kg −1 BW could be used as a hair-loosening agent in Angora goats. Therefore, it can be inferred that the appropriate CPA dose is related to the administration method and animal species.…”

Section: Discussionmentioning

confidence: 99%

The effects of the method and dose of cyclophosphamide administration on cashmere shedding

Chen

Yao

2019

R. Bras. Zootec.

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The objective of this study was to investigate the effects of the method and dose of cyclophosphamide (CPA) administration on cashmere shedding. Thirtytwo castrated Liaoning cashmere goats were randomly allotted to four groups, with eight replicates in each group. Goats in the four groups were injected intravenously or intramuscularly with CPA at doses of 20 or 25 mg kg −1 body weight (BW), respectively. Feed intake and BW were recorded, and erythrocyte count, hemoglobin content, and cashmere weight were determined. It was found that the CPA administration method had no significant effect on feed intake or BW of cashmere goats. Cyclophosphamide injection can significantly decrease the erythrocyte count and hemoglobin content of cashmere goats, but the effects are dependent on injection method and CPA dose. The injection method and dose did not significantly influence cashmere weight, but the method had significant effects on time to initiate shedding and regrown hair length. Regrown hair was longest by intramuscular injection with 20 mg kg −1 BW, which also caused the least erythema on the epidermis during the days after shedding. The results indicate that the CPA administration method can significantly influence cashmere shedding. Intramuscular injection of CPA at a dose of 20 mg kg −1 BW was found to be relatively beneficial for hair removal and regrowth in cashmere goats.

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Hair loosening in Angora goats using cyclophosphamide

Cited by 2 publications

References 8 publications

The induction of cashmere shedding via cyclophosphamide injection

The induction of cashmere shedding via cyclophosphamide injection

The effects of the method and dose of cyclophosphamide administration on cashmere shedding

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