Hair Metal Levels and Childhood Weight Gain

Vigeh, Mohsen; Yokoyama, Kazuhito; Matsukawa, Tetsuya; Shinohara, Atsuko; Ohtani, Kazuhiro; Shariat, Mamak

doi:10.18502/ijph.v49i8.3895

Cited by 3 publications

(3 citation statements)

References 35 publications

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“…Błażewicz (2013) 10) showed lower plasma and blood cobalt concentrations in children with obesity than in those without obesity; however, the study failed to demonstrate the same results for UCo. Similarly, Vigeh (2017) and Skalnaya (2018) reported higher levels of hair cobalt in children and adults with low body weight than in those with normal weight 13 , 17) . In adult women and children, an inverse correlation has been reported between cobalt levels in the toenail 16) and serum 12) , respectively, and BMI.…”

Section: Discussionmentioning

confidence: 94%

“…Concentrations of trace elements in children's urine samples were measured by inductively coupled plasma-mass spectrometry (ICP-MS) 13 , 36) or inductively coupled plasma-atomic emission spectrometry (ICP-AES), as previously reported 37) . ICP-MS (Agilent 8800, Agilent Technologies, California, USA) was used for determining Li, V, Cr, Co, Ni, Cu, Zn, As, Se, Sr, Mo, Cd, Ba, and Tl, and ICP-AES (Optima 2100, PerkinElmer, Massachusetts, USA) was used for measuring Na, Ca, Mg, and K. For the measurement preparation, urine samples were melted at room temperature and mixed with 0.5 % HNO 3 with 5-fold dilution in ICP-MS and analyzed by the multi-element standard solution XSTC-13 (SPEX CertiPrep, New Jersey, USA) as the external standard solution.…”

Section: Methodsmentioning

confidence: 99%

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Effects of Trace Elements on Anthropometric Characteristics of Children: Cobalt and Childhood Body Mass Index

TETSUKA,

MATSUKAWA,

YOKOYAMA

et al. 2022

Juntendo Medical Journal

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Objectives There are many reports on the effects of trace elements on human anthropometric characteristics. Among these elements, cobalt has consistently shown an inverse relationship with obesity risk. In the present study, we aimed to investigate the relationship between urinary levels of trace elements, focusing on cobalt, and childhood obesity, as indicated by the body mass index (BMI) in early adolescents, focusing on the participants' gender. Design A cross-sectional study was conducted in the Tokyo Teen Cohort study. Based on urinary samples, we obtained the anthropometric characteristics (weight and height) and potential covariates associated with childhood BMI for 1542 children (mean age=12 years; 860 boys and 682 girls). Methods Concentrations of urinary cobalt and 17 other trace elements were measured using inductively coupled plasma-mass spectrometry or inductively coupled plasma-atomic emission spectrometry. Results Pearson's correlation coefficient revealed an inverse relationship between the log of cobalt concentrations in the urine and the BMI for the boys (r=-0.125, p<0.001) and girls (r=-0.082, p=0.033). Multivariate analysis, adjusted for various covariates, reconfirmed the correlation between urine cobalt and the childhood BMI, only in the boys (beta=-0.14, p<0.001). Conclusions Among the 18 elements measured in the children's urine, cobalt may exhibit sufficient potency to decrease the risk of childhood obesity, particularly in boys. Future studies are required to clearly determine the magnitude of the effect and the underlying mechanism(s).

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Section: Discussionmentioning

confidence: 94%

Section: Methodsmentioning

confidence: 99%

Effects of Trace Elements on Anthropometric Characteristics of Children: Cobalt and Childhood Body Mass Index

TETSUKA,

MATSUKAWA,

YOKOYAMA

et al. 2022

Juntendo Medical Journal

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“…In some cases, studies are in relationship to smoking, dietary or industrial activity in the area; gender influence; or military attacks [46][47][48][49][50]. More recently, attention has been paid to assess heavy metals in relation to autism [48,49] and other developmental impairment in children and adolescents [51][52][53] as well as the relationship with secondhand cigarette smoke exposure [54], but most studies deal with only a few elements, mainly Hg, Cd, Al, Co, Cu, Ni and Cr. One study in Ethiopia evaluated up to 41 elements in the hair of children.…”

Section: Introductionmentioning

confidence: 99%

Reference Values on Children’s Hair for 28 Elements (Heavy Metals and Essential Elements) Based on a Pilot Study in a Representative Non-Contaminated Local Area

Ruíz

Estevan

Estévez

et al. 2023

IJMS

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Studies have been published, and laboratories offer services of measuring elements in hair as biomarkers of environmental exposure and/or control of essential elements (trace or macro). These reported values can have only sense if compared with adopted reference values. In this work, we propose provisional reference values based on a pilot child population. The concentrations of 28 elements were measured in children’s hair samples. An observational, descriptive, cross-sectional study was conducted in a typical child population in the Mediterranean region void of excessive pollution problems to analyze 419 hair samples of children aged 3–12 years. Children were selected by a simple random method from eight primary education schools in different municipal districts, which included urban, rural and industrial areas. Samples of around 100 mg were washed and acid digested by an optimized procedure. All measures were performed using ICP-MS with Sc, Y and Re as internal standards. The statistical analysis was performed by two approaches: (a) considering all the data and (b) without outliers (second-order atypical data) to compare them with other published studies. The distribution curves in all the elements studied were asymmetric and did not fit the theoretical normality distributions. Therefore, the analysis based on percentiles was more appropriate. In most elements, only slight differences were observed with sex or age, which did not justify proposing separate reference ranges. From the results of this study, provisional reference values are proposed following two criteria: (a) simple application of the table of percentiles built by removing outlier values and (b) values after a detailed analysis case-by-case, considering other data as the distribution profile and other published data of each element. Although the pilot sample was from a limited area, it was carefully selected to be representative of a general non-contaminated population. With this limitation, the proposed reference values might be useful for researchers and physicians until a wider geographical study is available for a large number of elements.

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Evaluation of lead levels in children with chronic constipation

Güney,

Doğan,

Toprak

2024

Turk J Pediatr

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Objectives. This study aimed to assess blood and hair lead levels (BLL and HLL) in children with chronic constipation and compare them to healthy children; and investigated lead exposure’s role in the etiology of constipation. It also explored the correlation between BLL and HLL. Study Design. The study included 84 constipated children aged 3-18 years as the case group and an equal number of constipation-free children as controls. Organic diseases were ruled out through history-taking, physical exams and laboratory tests. Blood and hair samples were collected and analyzed for lead levels using standardized methods. Results. The constipated children group had significantly higher BLL (3.66 µg/dL) compared to the control group (1.61 µg/dL) with no significant HLL difference. Additionally, 48.8% of constipated children exceeded the reference value of 3.5 μg/dL, in contrast to 4.8% of the control group. BLL was unaffected by gender and age, while HLL were higher in girls and low ages. No significant correlation existed between BLL and HLL. The age of the housing showed a positive correlation with higher BLL and HLL. Lead exposure sources like drinking water, home renovation history, parental smoking, or nearby industrial facilities showed no significant relationships with lead levels. Conclusions. Understanding the constipation-lead exposure link is crucial for prevention and intervention. HLL may vary with gender and age due to external lead particles, which is why BLL continues to be a more reliable measure. Healthcare providers should remember to investigate lead exposure risk factors in constipation patients and test BLL when necessary.

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Hair Metal Levels and Childhood Weight Gain

Cited by 3 publications

References 35 publications

Effects of Trace Elements on Anthropometric Characteristics of Children: Cobalt and Childhood Body Mass Index

Effects of Trace Elements on Anthropometric Characteristics of Children: Cobalt and Childhood Body Mass Index

Reference Values on Children’s Hair for 28 Elements (Heavy Metals and Essential Elements) Based on a Pilot Study in a Representative Non-Contaminated Local Area

Evaluation of lead levels in children with chronic constipation

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