Hair regenerative effect of silk fibroin hydrogel with incorporation of FGF-2-liposome and its potential mechanism in mice with testosterone-induced alopecia areata

Xu, He‐Lin; Chen, Pian-Pian; Wang, Lifen; Wang, Xue; Fu, Ting-Ling

doi:10.1016/j.jddst.2018.09.006

Cited by 18 publications

(11 citation statements)

References 25 publications

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“…In this approach we have studied the ligand–protein interaction along with their docked confirmation on selected protein namely 2FGF, 2PVC and 4U7P. The said proteins belong to the class of DNMT1, DNMT3a, DNMT3b, DNMT3L and TETs, which explored the stability of the selected structure to the genetic material and expression by epigenetic modification of DNA, which proved the noteworthy role in hair growth [ [45] , [46] , [47] ]. The results revealed that the docking score of Dimethyl sulfone was almost comparables result with Minoxidil.…”

Section: Discussionmentioning

confidence: 99%

Isolation and identification of hair growth potential fraction from active plant extract of Blumea eriantha DC grown in Western Ghat of India: In silico study

Bhinge¹,

Jadhav

Randive³

et al. 2022

Journal of Ayurveda and Integrative Medicine

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Section: Discussionmentioning

confidence: 99%

Isolation and identification of hair growth potential fraction from active plant extract of Blumea eriantha DC grown in Western Ghat of India: In silico study

Bhinge¹,

Jadhav

Randive³

et al. 2022

Journal of Ayurveda and Integrative Medicine

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“…Interestingly, the gene related to hairlessness in Mexican Hairless dogs is also related to dentition (Drögemüller et al, 2008), implying plausibility for a hair-related gene to also be tooth-related. Furthermore, numerous fibroblast growth factor genes have been studied in relation to hair growth (Rosenquist & Martin, 1996), including work that found errors in FGF5 resulted in longer hair in goats (Li et al, 2019), FGF5 and FGF7 regulation controlled hair anagen phase in mice (Lee et al, 2019), and FGF2 stimulated hair growth when applied to mouse skin (Xu, Chen, Wang, Xue, & Fu, 2018). FGF11 is an excellent candidate to perform similar tests for hair-related functions, among other high-scoring genes in the list such as MYH4 and ANXA11 .…”

Section: Discussionmentioning

confidence: 99%

Complementary evolution of coding and noncoding sequence underlies mammalian hairlessness

Kowalczyk

Chikina

Clark

2021

Preprint

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Body hair is a defining mammalian characteristic, but several mammals, such as whales, naked mole-rats, and humans, have notably less hair than others. To find the genetic basis of reduced hair quantity, we used our evolutionary-rates-based method, RERconverge, to identify coding and noncoding sequences that evolve at significantly different rates in so-called hairless mammals compared to hairy mammals. Using RERconverge, we performed an unbiased, genome-wide scan over 62 mammal species using 19,149 genes and 343,598 conserved noncoding regions to find genetic elements that evolve at significantly different rates in hairless mammals compared to hairy mammals. We show that these rate shifts resulted from relaxation of evolutionary constraint on hair-related sequences in hairless species. In addition to detecting known and potential novel hair-related genes, we also discovered hundreds of putative hair-related regulatory elements. Computational investigation revealed that genes and their associated noncoding regions show different evolutionary patterns and influence different aspects of hair growth and development. Many genes under accelerated evolution are associated with the structure of the hair shaft itself, while evolutionary rate shifts in noncoding regions also included the dermal papilla and matrix regions of the hair follicle that contribute to hair growth and cycling. Genes that were top-ranked for coding sequence acceleration included known hair and skin genes KRT2, KRT35, PKP1, and PTPRM that surprisingly showed no signals of evolutionary rate shifts in nearby noncoding regions. Conversely, accelerated noncoding regions are most strongly enriched near regulatory hair-related genes and microRNAs, such as mir205, ELF3, and FOXC1, that themselves do not show rate shifts in their protein-coding sequences. Such dichotomy highlights the interplay between the evolution of protein sequence and regulatory sequence to contribute to the emergence of a convergent phenotype.

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“…The FITC-labeled aFGF was obtained using the standard method according to previous study ( Xu et al, 2018 , Zhao et al, 2019 ) after which the fluorescence-labeled aFGF was used to prepare aFGF@Lips and aFGF@NMLs. The BEAS-2B cells were first stimulated by LPS (10 μg/mL) for 12 h to activate the inflammatory microenvironment.…”

Section: Methodsmentioning

confidence: 99%

Neutrophil membrane-coated therapeutic liposomes for targeted treatment in acute lung injury

Huang

Wang

Long

et al. 2022

International Journal of Pharmaceutics

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Hair regenerative effect of silk fibroin hydrogel with incorporation of FGF-2-liposome and its potential mechanism in mice with testosterone-induced alopecia areata

Cited by 18 publications

References 25 publications

Isolation and identification of hair growth potential fraction from active plant extract of Blumea eriantha DC grown in Western Ghat of India: In silico study

Isolation and identification of hair growth potential fraction from active plant extract of Blumea eriantha DC grown in Western Ghat of India: In silico study

Complementary evolution of coding and noncoding sequence underlies mammalian hairlessness

Neutrophil membrane-coated therapeutic liposomes for targeted treatment in acute lung injury

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