“…However, for cocaine detection, there are some limitations, including limited window of detection, occurrence of false-negatives as a consequence of very low cocaine concentrations in samples, specific requirements for storage, possibility of sample dilution in vivo by excessive fluid ingestion, requirement of collection under observation to avoid adulteration or sample exchange, or even absence of urine specimens in postmortem cases (Cone et al, 1998;Cone et al, 2003;Musshoff et al, 2006;Polla et al, 2009). …”