Hairless triggers reactivation of hair growth by promoting Wnt signaling

Beaudoin, Gerard M.J.; Sisk, Jeanne M.; Coulombe, Pierre A.; Thompson, Catherine C.

doi:10.1073/pnas.0507609102

Cited by 138 publications

(143 citation statements)

References 47 publications

(52 reference statements)

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“…The expression of several genes such as keratinocyte differentiation markers and wise, was up-regulated in Hairless KO mice (Zarach et al, 2004;Beaudoin et al, 2005). Hairless represses the promoter activity of wise (Beaudoin et al, 2005). These studies link the molecular functions of Hairless to the functions in skin and hair development.…”

Section: Hairlessmentioning

confidence: 76%

“…Because Hairless is a transcriptional repressor, altered expression of genes would cause the phenotypes of Hairless mutants. The expression of several genes such as keratinocyte differentiation markers and wise, was up-regulated in Hairless KO mice (Zarach et al, 2004;Beaudoin et al, 2005). Hairless represses the promoter activity of wise (Beaudoin et al, 2005).…”

Section: Hairlessmentioning

confidence: 96%

“…Analysis of the KO mice revealed increased proliferation and changes of cell types in the epidermis, suggesting that Hairless is required for normal balance of cell proliferation and differentiation in the epidermis cells (Zarach et al, 2004). The rescue experiments using transgenic mice showed that expression of Hairless in progenitor keratinocytes is required for hair follicle regeneration (Beaudoin et al, 2005). Hairless represses expression of Wise, a modulator of Wnt signaling, coincident with the timing of follicle regeneration.…”

Section: Hairlessmentioning

confidence: 99%

“…Hairless represses expression of Wise, a modulator of Wnt signaling, coincident with the timing of follicle regeneration. From these studies, a model in which Hair-less regulates the precise timing of Wnt signaling required for hair follicle regeneration was proposed (Beaudoin et al, 2005).…”

Section: Hairlessmentioning

confidence: 99%

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Roles of jumonji and jumonji family genes in chromatin regulation and development

Takeuchi

Watanabe

Takano-Shimizu

et al. 2006

Developmental Dynamics

177

148

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The jumonji (jmj) gene was identified by a mouse gene trap approach and has essential roles in the development of multiple tissues. The Jmj protein has a DNA binding domain, ARID, and two conserved jmj domains (jmjN and jmjC). In many diverse species including bacteria, fungi, plants, and animals, there are many jumonji family proteins that have only the jmjC domain or both jmj domains. Recently, Jmj protein was found to be a transcriptional repressor. Several proteins in the jumonji family are involved in transcriptional repression and/or chromatin regulation. Most recently, one of the human members has been shown to be a histone demethylase, and the jmjC domain is essential for the demethylase activity. Meanwhile, more and more evidence indicating that the jumonji family proteins play important roles during development is accumulating. Many proteins in the jumonji family may regulate chromatin and gene expression, and control development through various signaling pathways. Here, we highlight the roles of jmj and jumonji family proteins in chromatin regulation and development. Developmental Dynamics 235: 2449 -2459, 2006.

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Section: Hairlessmentioning

confidence: 76%

Section: Hairlessmentioning

confidence: 96%

Section: Hairlessmentioning

confidence: 99%

Section: Hairlessmentioning

confidence: 99%

See 2 more Smart Citations

Roles of jumonji and jumonji family genes in chromatin regulation and development

Takeuchi

Watanabe

Takano-Shimizu

et al. 2006

Developmental Dynamics

177

148

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“…This was confirmed in mice by the co-localization of axin2, a β-catenin target gene with hair regrowth. 69 Feathers. The location of chicken feather stem cells was also found by searching for slow cycling cells.…”

Section: Adult Stem Cellsmentioning

confidence: 99%

Wnt signaling in skin organogenesis

Widelitz

2008

Organogenesis

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While serving as the interface between an organism and its environment, the skin also can elaborate a wide range of skin appendages to service specific purposes in a region-specific fashion. As in other organs, Wnt signaling plays a key role in regulating the proliferation, differentiation and motility of skin cells during their morphogenesis. Here I will review some of the recent work that has been done on skin organogenesis. I will cover dermis formation, the development of skin appendages, cycling of appendages in the adult, stem cell regulation, patterning, orientation, regional specificity and modulation by sex hormone nuclear receptors. I will also cover their roles in wound healing, hair regeneration and skin related diseases. It appears that Wnt signaling plays essential but distinct roles in different hierarchical levels of morphogenesis and organogenesis. Many of these areas have not yet been fully explored but are certainly promising areas of future research.The integument forms the interface between an organism and its environment. 1,2 As such it protects against dehydration, infection, temperature extremes, etc while providing a means for display, camouflage and other functions. 3 The skin can elaborate remarkable structural diversity producing specialized functions in a region-specific fashion to provide organisms with a selective advantage. For example, the development of feathers led to the acquisition of flight in birds and the formation of mammary glands enabled mammals to nurse their young. 4 The advantage of these evolutionary developments can be seen by the number of birds and mammals present today.Skin appendages, such as skin, hairs, feathers, scales, glands and teeth grow from the epithelium as a result of epithelial-mesenchymal interactions, 5 largely in response to common molecular signals with slight variations in their placement and timing during tissue morphogenesis. 6 Theoretically, stem cells are totipotent and progressively can be guided toward their specific fates by exposure to specific regulatory signals. The juxtaposition of molecular signals or lack thereof may have a tremendous impact on cell fate decisions. Hence, the difference between skin appendages is due to the topological arrangement of the epithelia during developmental processes. These are presumably regulated by adhesion molecules whose expression is controlled by signaling molecules as well as by physical constraints.Hairs and feathers are attractive model systems for experimental research because of their ability for seasonal or periodic renewal. Obviously not all hairs or feathers are replaced at one time or birds would lose all of their feathers at once and fall from the sky in midflight; rather hairs and feathers are replaced over a period of time in a wave-like pattern. 7 Yet this cycling behavior enables thousands of entirely new organs to be regenerated again and again throughout these animal's lives. Hairs and feathers demonstrate an incredible diversity of forms arising in different locations over the bod...

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Hairless (Hr) Deficiency Mitigates High‐Fat Diet‐Induced Obesity and Insulin Resistance in Mice

Wang,

Guo,

Zhu

et al. 2024

Advanced Biology

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Obesity is a significant global health concern linked to excessive dietary energy intake. This research focuses on the mammalian hairless protein (HR), known for its role in skin and hair function, and its impact on metabolism. Examining male wild‐type (Hr+/+) and Hr null (Hr−/−) mice over a 14‐week normal chow diet (NCD) or high‐fat diet (HFD) intervention. This study reveals that HR deficiency exhibited a protective effect against HFD‐induced obesity and insulin resistance. This protective effect is attributed to increased energy expenditure in Hr−/− mice. Moreover, the brown adipose tissue (BAT) of Hr−/− mice displays elevated levels of the thermogenic protein, uncoupling protein 1 (Ucp1), and its key transcriptional regulators (PPARγ and PGC1α), compared to Hr+/+ mice. In summary, the findings underscore the protective role of HR deficiency in countering HFD‐induced adiposity by enhancing insulin sensitivity, raising energy expenditure, and augmenting thermogenic factors in BAT. Further exploration of HR metabolic regulation holds promise for potential therapeutic targets in addressing obesity‐related metabolic disorders.

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Hairless triggers reactivation of hair growth by promoting Wnt signaling

Cited by 138 publications

References 47 publications

Roles of jumonji and jumonji family genes in chromatin regulation and development

Roles of jumonji and jumonji family genes in chromatin regulation and development

Wnt signaling in skin organogenesis

Hairless (Hr) Deficiency Mitigates High‐Fat Diet‐Induced Obesity and Insulin Resistance in Mice

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