Hairy Cell Leukemia and HCL-Like Disorders: Diagnosis and TreatmentLeuc閙ie �Tricholeucocytes et Autres Prolif閞ations �Cellules Chevelues: Diagnostic et Traitement

Maître, Elsa; Troussard, Xavier

doi:10.32604/oncologie.2022.021490

Cited by 4 publications

(2 citation statements)

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“…Data indicates that within 2 years of diagnosis, over 80% of patients experience recurrence, Am J Cancer Res 2024;14 (1):145-154 with only 7% to 12.7% surviving for at least 5 years [9]. Immunochemotherapy currently serves as the first-line standard of treatment for various diseases, including glioma and hairy cell leukemia (HCL-V) [10]. As bone marrow is frequently involved at the diagnosis and relapse stages of stage 4 NB, analyzing the characteristics of bone marrow relapse in HR-NB could provide valuable insights influencing future HR-NB strategies [11,12].…”

Section: Introductionmentioning

confidence: 99%

Bone marrow relapse in stage 4 neuroblastoma of children in Shanghai

2024

Am J Cancer Res

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Objective: To characterize the epidemiological, clinical, and molecular features of bone marrow relapse in high-risk neuroblastoma (HR-NB) and to identify potential prognostic indicators and therapeutic approaches for this specific subset within the Shanghai pediatric oncology landscape. Methods: A retrospective study was conducted on 256 patients diagnosed with stage 4 neuroblastoma at two major pediatric hospitals in Shanghai, China, between 2008 and 2018. Patient data was collected, including demographic information, treatment regimens, and outcomes. Kaplan-Meier method and log-rank test were used for overall survival (OS) and event-free survival (EFS) analysis. Results: The study revealed that bone marrow relapse affected 50.78% of patients, making it the most frequent relapse site. Patients with bone marrow involvement at diagnosis face an increased risk of subsequent bone marrow relapse. Age over 18 months, multiple metastatic sites, and the absence of autologous stem cell transplantation (ASCT) were identified as significant risk factors for bone marrow relapse. The 3-year OS and EFS rates of patients with bone marrow relapse were 32.5% and 32.5%, respectively. Patients receiving ASCT demonstrated significantly higher survival rates. The lack of ASCT at diagnosis was significantly correlated with lower survival rates, particularly in patients experiencing bone marrow relapse. Conclusion: The study provides valuable insights into the challenges posed by bone marrow relapse in the setting of high-risk neuroblastoma. It emphasizes the need for tailored therapeutic approaches to improve outcomes, potentially involving novel targeted agents and immunotherapies. The study underscores the poor prognosis associated with bone marrow relapse in HR-NB and the urgent need for further research to optimize risk stratification and therapeutic strategies, including prospective investigation and the integration of advanced molecular profiling techniques.

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Section: Introductionmentioning

confidence: 99%

Bone marrow relapse in stage 4 neuroblastoma of children in Shanghai

2024

Am J Cancer Res

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“…Acute myeloid leukemia (AML) is a genetically heterogenous malignancy arising from uncontrolled proliferation of clonal hematopoietic cells [1,2]. AML primarily comprises acute erythroid leukemia and acute megakaryoblastic leukemia [3].…”

Section: Introductionmentioning

confidence: 99%

LncRNA AL645608.3 mediates malignant progression of acute myeloid leukemia

Yan

2024

Am J Transl Res

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Objective: To investigate the role of lncRNA AL645608.3 in the malignant progression of acute myeloid leukemia (AML) cells and explore relevant molecular mechanisms. Methods: The expression level of AL645608.3 was measured in AML cell lines (THP-1, HL-60, KG-1, and AML-193) via real-time quantitative polymerase chain reaction (RT-qPCR). Small hairpin RNA (shRNA) and open reading frame of AL645608.3 were cloned into lentiviral vectors and were infected into THP-1 and AML-193 cells. The expression of casitas B-lineage lymphoma (CBL), interferon regulatory factor 6 (IRF6), and interferon beta 1 (IFNB1) was detected through RT-qPCR, and western blot. Co-immunoprecipitation (Co-IP) on IRF6 was conducted. Matrix metalloprotease-9 (MMP-9) activity was evaluated via gelatin zymography assay. Results: LncRNA AL645608.3 was expressed in the four AML cell lines (THP-1, HL-60, KG-1, and AML-193). Silencing AL645608.3 mitigated the expression of IRF6 and IFNB1 but elevated the expression of CBL in THP-1 cells. Oppositely, AL645608.3 overexpression up-regulated the expression of IRF6 and IFNB1 but decreased the expression of CBL in AML-193 cells. Co-IP results proved that AL645608.3 could directly mediate IRF6 activity in THP-1 and AML-193 cells. MMP-9 activity was decreased by AL645608.3 knockdown and was improved by AL645608.3 overexpression in AML-193 cells. Conclusion: AL645608.3 is expressed in different AML cell lines, and mediates the expression of CBL, IRF6, IFNB1, and MMP-9. These findings might deepen our comprehension of the molecular mechanisms underlying AML.

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The role of ADC value and Ki-67 index in predicting the response to neoadjuvant chemotherapy in advanced stages of olfactory neuroblastoma

Wang

Zhang

et al. 2022

BJR

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Objectives: To investigate the efficacy of pretreatment ADC and Ki-67 index in the prediction of the response to neoadjuvant chemotherapy (NACT) in advanced olfactory neuroblastoma (ONB) patients. Methods: A total of 21 advanced ONB patients (mean 43.48 years ± 14.26; range 25–69 years; 13 men and 8 women) with diffusion weighted imaging (DWI) before NACT between June 2015 and October 2021 were retrospectively analyzed. Patients were categorized into responders and non-responders according to RECIST 1.1 after two cycles of NACT. The clinical data, ADCmean value and Ki-67 index were analyzed. Results: Kadish stage, ADCmean value and Ki-67 index showed statistical significance between responders and non-responders. Patients with Kadish C stage were more likely to respond to platinum-based NACT (p = 0.035). Patients with the lower ADCmean value showed response to NACT (p = 0.002) and the cutoff point was 1.04 × 10−3 mm2/s. Patients with the higher Ki-67 index showed response to NACT (p = 0.003) and the cutoff point was 17.5%. Predictive performance of Ki-67 index and ADCmean value showed no significance between responders and non-responders (p = 0.865). A significant negative correlation was found between ADCmean value and Ki-67 index (r = −0.539, p = 0.038). Conclusions: The pretreatment ADCmean value, Ki-67 index and Kadish stage have the potential to predict the response to NACT in advanced ONB patients. Advances in knowledge: This is the first study that investigated the feasibility of DWI in predicting the response to NACT in ONB patients, and showed that Kadish stage, pretreatment ADCmean and Ki-67 index may play an important role in the prediction.

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Hairy Cell Leukemia and HCL-Like Disorders: Diagnosis and TreatmentLeuc閙ie �Tricholeucocytes et Autres Prolif閞ations �Cellules Chevelues: Diagnostic et Traitement

Cited by 4 publications

References 147 publications

Bone marrow relapse in stage 4 neuroblastoma of children in Shanghai

Bone marrow relapse in stage 4 neuroblastoma of children in Shanghai

LncRNA AL645608.3 mediates malignant progression of acute myeloid leukemia

The role of ADC value and Ki-67 index in predicting the response to neoadjuvant chemotherapy in advanced stages of olfactory neuroblastoma

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